1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase

1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase
HisAp hexamer, Arthrobacter aurescens
Identifiers
EC no.	5.3.1.16
CAS no.	37318-43-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase (EC 5.3.1.16, N-(5-phospho-D-ribosylformimino)-5-amino-1-(5-phosphoribosyl)-4-imidazolecarboxamide isomerase, phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase, N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase) is an enzyme with systematic name 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide aldose-ketose-isomerase. ^[1] This enzyme catalyses the following chemical reaction

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ${\displaystyle \rightleftharpoons }$ 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]-1-(5-phosphoribosyl)imidazole-4-carboxamide

References

1. Margolies MN, Goldberger RF (July 1966). "Isolation of the fourth (isomerase) of histidine biosynthesis from Salmonella typhimurium". The Journal of Biological Chemistry. 241 (14): 3262–9. doi: 10.1016/S0021-9258(18)96459-8 . PMID   5330429.

External links

• 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide+isomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)