3,5,7-Trioxododecanoyl-CoA synthase

Last updated
3,5,7-Trioxododecanoyl-CoA synthase
Identifiers
EC no. 2.3.1.206
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

3,5,7-Trioxododecanoyl-CoA synthase (EC 2.3.1.206, TKS) is an enzyme with systematic name malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming). [1] [2] This enzyme catalyses the following chemical reaction

3 malonyl-CoA + hexanoyl-CoA 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2

This polyketide synthase catalyse the first step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa .

References

  1. Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S (June 2009). "Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway". FEBS Letters. 583 (12): 2061–6. Bibcode:2009FEBSL.583.2061T. doi:10.1016/j.febslet.2009.05.024. PMID   19454282. S2CID   13746503.
  2. Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE (July 2012). "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proceedings of the National Academy of Sciences of the United States of America. 109 (31): 12811–6. Bibcode:2012PNAS..10912811G. doi: 10.1073/pnas.1200330109 . PMC   3411943 . PMID   22802619.