4-hydroxybenzaldehyde dehydrogenase

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4-hydroxybenzaldehyde dehydrogenase
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EC no. 1.2.1.64
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In enzymology, a 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzaldehyde + NAD+ + H2O 4-hydroxybenzoate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxybenzaldehyde, NAD+, and H2O, whereas its 3 products are 4-hydroxybenzoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation in bacteria. [1] [2] It is also found in carrots ( Daucus carota ). [3]

Related Research Articles

4-Hydroxybenzoic acid, also known as p-hydroxybenzoic acid (PHBA), is a monohydroxybenzoic acid, a phenolic derivative of benzoic acid. It is a white crystalline solid that is slightly soluble in water and chloroform but more soluble in polar organic solvents such as alcohols and acetone. 4-Hydroxybenzoic acid is primarily known as the basis for the preparation of its esters, known as parabens, which are used as preservatives in cosmetics and some ophthalmic solutions. It is isomeric with 2-hydroxybenzoic acid, known as salicylic acid, a precursor to aspirin, and with 3-hydroxybenzoic acid.

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<span class="mw-page-title-main">Aminomuconate-semialdehyde dehydrogenase</span>

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<span class="mw-page-title-main">4-Hydroxybenzaldehyde</span> Chemical compound

4-Hydroxybenzaldehyde is one of the three isomers of hydroxybenzaldehyde. It can be found in the orchids Gastrodia elata, Galeola faberi, and the Vanilla orchids.

References

  1. ↑ Bossert ID, Whited G, Gibson DT, Young LY (1989). "Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium". J. Bacteriol. 171 (6): 2956–62. PMC   210000 . PMID   2722739.
  2. ↑ Whited GM, Gibson DT (1991). "Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1". J. Bacteriol. 173 (9): 3017–20. PMC   207886 . PMID   2019564.
  3. ↑ Sircar, D.; Mitra, A. (2008). "Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota". Journal of Plant Physiology. 165 (4): 407–414. doi:10.1016/j.jplph.2007.05.005. PMID   17658659.


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