APOBEC2

APOBEC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NYT
Identifiers
Aliases	APOBEC2 , ARCD1, ARP1, apolipoprotein B mRNA editing enzyme catalytic subunit 2
External IDs	OMIM: 604797; MGI: 1343178; HomoloGene: 4941; GeneCards: APOBEC2; OMA:APOBEC2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.1 Start 41,053,202 bp [1] End 41,064,891 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 C|17 24.02 cM Start 48,726,259 bp [2] End 48,739,958 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii triceps brachii muscle Skeletal muscle tissue of biceps brachii muscle of thigh glutes thoracic diaphragm vastus lateralis muscle deltoid muscle apex of heart Top expressed in quadriceps femoris muscle muscle of thigh zone of skin esophagus skeletal muscle tissue heart lip epithelium of urethra ejaculatory duct epithelium of male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines zinc ion binding catalytic activity hydrolase activity metal ion binding RNA binding cytidine deaminase activity identical protein binding Cellular component nucleus cytoplasm Biological process DNA demethylation mRNA processing mRNA modification cytidine deamination cytidine to uridine editing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10930 11811 Ensembl ENSG00000124701 ENSMUSG00000040694 UniProt Q9Y235 Q9WV35 RefSeq (mRNA) NM_006789 NM_009694 RefSeq (protein) NP_006780 NP_033824 Location (UCSC) Chr 6: 41.05 – 41.06 Mb Chr 17: 48.73 – 48.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable C->U-editing enzyme APOBEC-2 is a protein that in humans is encoded by the APOBEC2 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000124701 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040694 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liao W, Hong SH, Chan BH, Rudolph FB, Clark SC, Chan L (Aug 1999). "APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family". Biochem Biophys Res Commun. 260 (2): 398–404. Bibcode:1999BBRC..260..398L. doi:10.1006/bbrc.1999.0925. PMID   10403781.
6. "Entrez Gene: APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2".

External links

• Human APOBEC2 genome location and APOBEC2 gene details page in the UCSC Genome Browser .

Further reading

• Wedekind JE, Dance GS, Sowden MP, Smith HC (2003). "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends Genet. 19 (4): 207–16. doi:10.1016/S0168-9525(03)00054-4. PMID   12683974.
• Lau PP, Zhu HJ, Baldini A, et al. (1994). "Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8522–6. Bibcode:1994PNAS...91.8522L. doi: 10.1073/pnas.91.18.8522 . PMC   44638 . PMID   8078915.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Oka K, Kobayashi K, Sullivan M, et al. (1997). "Tissue-specific inhibition of apolipoprotein B mRNA editing in the liver by adenovirus-mediated transfer of a dominant negative mutant APOBEC-1 leads to increased low density lipoprotein in mice". J. Biol. Chem. 272 (3): 1456–60. doi: 10.1074/jbc.272.3.1456 . PMID   8999814.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Anant S, Mukhopadhyay D, Sankaranand V, et al. (2001). "ARCD-1, an apobec-1-related cytidine deaminase, exerts a dominant negative effect on C to U RNA editing". Am. J. Physiol., Cell Physiol. 281 (6): C1904–16. doi:10.1152/ajpcell.2001.281.6.C1904. PMID   11698249. S2CID   7343760.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Prochnow C, Bransteitter R, Klein MG, et al. (2007). "The APOBEC-2 crystal structure and functional implications for the deaminase AID". Nature. 445 (7126): 447–51. Bibcode:2007Natur.445..447P. doi:10.1038/nature05492. PMID   17187054. S2CID   4394772.