All-trans-octaprenyl-diphosphate synthase

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All-trans-octaprenyl-diphosphate synthase
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Identifiers
EC no. 2.5.1.90
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All-trans-octaprenyl-diphosphate synthase (EC 2.5.1.90, octaprenyl-diphosphate synthase, octaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-heptaprenyltranstransferase, trans-prenyltransferase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units). [1] [2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate 5 diphosphate + all-trans-octaprenyl diphosphate

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate.

References

  1. Fujisaki S, Nishino T, Katsuki H (May 1986). "Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis". Journal of Biochemistry. 99 (5): 1327–37. doi:10.1093/oxfordjournals.jbchem.a135600. PMID   3519603.
  2. Asai K, Fujisaki S, Nishimura Y, Nishino T, Okada K, Nakagawa T, Kawamukai M, Matsuda H (July 1994). "The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase". Biochemical and Biophysical Research Communications. 202 (1): 340–5. Bibcode:1994BBRC..202..340A. doi:10.1006/bbrc.1994.1933. PMID   8037730.