DCP1B

DCP1B
Identifiers
Aliases	DCP1B , DCP1, hDcp1b, decapping mRNA 1B
External IDs	OMIM: 609843 MGI: 2442404 HomoloGene: 51881 GeneCards: DCP1B
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.33 Start 1,946,053 bp [1] End 2,004,535 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F1 Start 119,175,253 bp [2] End 119,221,616 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0010576 enzyme regulator activity • GO:0010577 enzyme activator activity • GO:0001948 protein binding • mRNA binding • hydrolase activity Cellular component • P-body • membrane • intracellular membrane-bounded organelle • nucleus • cytoplasm • cytosol Biological process • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • GO:0048554 positive regulation of catalytic activity • deadenylation-independent decapping of nuclear-transcribed mRNA • deadenylation-dependent decapping of nuclear-transcribed mRNA • exonucleolytic catabolism of deadenylated mRNA Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	196513	319618
Ensembl	ENSG00000151065 ENSG00000284850	ENSMUSG00000041477
UniProt	Q8IZD4	Q3U564
RefSeq (mRNA)	NM_152640 NM_001319292	NM_001033379
RefSeq (protein)	NP_001306221 NP_689853	NP_001028551
Location (UCSC)	Chr 12: 1.95 – 2 Mb	Chr 6: 119.18 – 119.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene. ^{[5] [6] [7]}

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM] ^[7]

References

1. ENSG00000284850 GRCh38: Ensembl release 89: ENSG00000151065, ENSG00000284850 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041477 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol. 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC   134073 . PMID   12417715.
6. Cougot N, Babajko S, Seraphin B (Apr 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". J Cell Biol. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC   2172085 . PMID   15067023.
7. "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Further reading

• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.