DCP1B

DCP1B
Identifiers
Aliases	DCP1B , DCP1, hDcp1b, decapping mRNA 1B
External IDs	OMIM: 609843; MGI: 2442404; HomoloGene: 51881; GeneCards: DCP1B; OMA:DCP1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.33 Start 1,946,053 bp [1] End 2,004,535 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F1 Start 119,175,253 bp [2] End 119,221,616 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon smooth muscle tissue body of uterus gonad myometrium right adrenal gland right adrenal cortex popliteal artery tibial arteries left adrenal gland Top expressed in seminiferous tubule superior cervical ganglion spermatocyte spermatid otolith organ utricle Rostral migratory stream genital tubercle spinal ganglia tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity enzyme activator activity protein binding mRNA binding hydrolase activity Cellular component P-body membrane intracellular membrane-bounded organelle nucleus cytoplasm cytosol Biological process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay positive regulation of catalytic activity deadenylation-independent decapping of nuclear-transcribed mRNA deadenylation-dependent decapping of nuclear-transcribed mRNA exonucleolytic catabolism of deadenylated mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196513 319618 Ensembl ENSG00000151065 ENSG00000284850 ENSMUSG00000041477 UniProt Q8IZD4 B9EIX0 RefSeq (mRNA) NM_152640 NM_001319292 NM_001033379 RefSeq (protein) NP_001306221 NP_689853 NP_001028551 Location (UCSC) Chr 12: 1.95 – 2 Mb Chr 6: 119.18 – 119.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

mRNA-decapping enzyme 1B is a protein that in humans is encoded by the DCP1B gene. ^{[5] [6] [7]}

DCP1B is a core component of the mRNA decapping complex, a key factor in the regulation of mRNA decay (Lykke-Andersen, 2002).[supplied by OMIM] ^[7]

References

1. ENSG00000284850 GRCh38: Ensembl release 89: ENSG00000151065, ENSG00000284850 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041477 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC   134073 . PMID   12417715.
6. Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC   2172085 . PMID   15067023.
7. "Entrez Gene: DCP1B DCP1 decapping enzyme homolog B (S. cerevisiae)".

Further reading

• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.