EDC3

EDC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Aliases	EDC3 , LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDs	OMIM: 609842; MGI: 2142951; HomoloGene: 11827; GeneCards: EDC3; OMA:EDC3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.1 Start 74,630,558 bp [1] End 74,696,292 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 57,615,823 bp [2] End 57,659,782 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis stromal cell of endometrium ganglionic eminence ventricular zone testicle islet of Langerhans gonad granulocyte right lobe of thyroid gland Top expressed in primitive streak hand otolith organ yolk sac Rostral migratory stream utricle otic vesicle external carotid artery trigeminal ganglion internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphodiesterase decapping endonuclease activity identical protein binding RNA binding mRNA binding Cellular component cytoplasm cytosol membrane P-body cytoplasmic ribonucleoprotein granule Biological process P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA phosphodiester bond hydrolysis, endonucleolytic deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80153 353190 Ensembl ENSG00000179151 ENSMUSG00000038957 UniProt Q96F86 Q8K2D3 RefSeq (mRNA) NM_001142443 NM_001142444 NM_025083 NM_001351378 NM_001351379 NM_153799 RefSeq (protein) NP_001135915 NP_001135916 NP_079359 NP_001338307 NP_001338308 NP_722494 Location (UCSC) Chr 15: 74.63 – 74.7 Mb Chr 9: 57.62 – 57.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene. ^{[5] [6] [7]}

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000179151 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038957 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Albrecht M, Lengauer T (Jun 2004). "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases". FEBS Lett. 569 (1–3): 18–26. Bibcode:2004FEBSL.569...18A. doi: 10.1016/j.febslet.2004.03.126 . PMID   15225602.
6. Rudolph C, Sigruener A, Hartmann A, Orso E, Bals-Pratsch M, Gronwald W, Seifert B, Kalbitzer HR, Verdorfer I, Luetjens CM, Ortmann O, Bornstein SR, Schmitz G (May 2007). "ApoA-I-binding protein (AI-BP) and its homologues hYjeF_N2 and hYjeF_N3 comprise the YjeF_N domain protein family in humans with a role in spermiogenesis and oogenesis". Horm Metab Res. 39 (5): 322–35. doi:10.1055/s-2007-977699. PMID   17533573. S2CID   10679128.
7. "Entrez Gene: EDC3 enhancer of mRNA decapping 3 homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi: 10.1016/j.cub.2004.07.051 . PMID   15324660. S2CID   2371325.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi: 10.1073/pnas.0404089101 . PMC   524842 . PMID   15498874.
• Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Mol. Cell. 20 (6): 905–15. doi: 10.1016/j.molcel.2005.10.031 . PMID   16364915.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Tritschler F, Eulalio A, Truffault V, Hartmann MD, Helms S, Schmidt S, Coles M, Izaurralde E, Weichenrieder O (2007). "A Divergent Sm Fold in EDC3 Proteins Mediates DCP1 Binding and P-Body Targeting". Mol. Cell. Biol. 27 (24): 8600–11. doi:10.1128/MCB.01506-07. PMC   2169425 . PMID   17923697.