PRPF4B

PRPF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IAN, 4IFC, 4IIR, 4IJP
Identifiers
Aliases	PRPF4B , PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDs	OMIM: 602338; MGI: 109584; HomoloGene: 134085; GeneCards: PRPF4B; OMA:PRPF4B - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p25.2 Start 4,021,267 bp [1] End 4,064,983 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A3.3 Start 34,875,302 bp [2] End 34,906,064 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Epithelium of choroid plexus mucosa of paranasal sinus Achilles tendon epithelium of nasopharynx ventricular zone left ovary body of uterus right ovary right uterine tube Top expressed in fossa condyle genital tubercle Paneth cell tail of embryo lobe of cerebellum cerebellar vermis substantia nigra otic placode saccule More reference expression data BioGPS n/a
Gene ontology Molecular function kinase activity transferase activity protein kinase activity protein serine/threonine kinase activity nucleotide binding protein binding ATP binding cyclin-dependent protein serine/threonine kinase activity RNA binding Cellular component catalytic step 2 spliceosome spliceosomal complex nucleus chromosome nuclear speck Biological process mRNA splicing, via spliceosome protein phosphorylation mRNA processing RNA splicing phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8899 19134 Ensembl ENSG00000112739 ENSMUSG00000021413 UniProt Q13523 Q61136 RefSeq (mRNA) NM_003913 NM_176800 NM_013830 RefSeq (protein) NP_003904 NP_038858 Location (UCSC) Chr 6: 4.02 – 4.06 Mb Chr 13: 34.88 – 34.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRP4K gene. ^{[5] [6] [7]} The gene was previously known as PRPF4B.

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). ^[7]

Interactions

PRP4K has been shown to interact with Pinin. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000112739 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021413 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
6. Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi: 10.1074/jbc.M103790200 . PMID   11418604.
7. "Entrez Gene: PRP4K PRP4 pre-mRNA processing factor 4 homolog B (yeast)".
8. Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. 22 (14). United States: 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. hdl:11858/00-001M-0000-0029-BC76-A. ISSN   0270-7306. PMC   139773 . PMID   12077342.

Further reading

• Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID   8274451.
• Gross T, Lützelberger M, Weigmann H, et al. (1997). "Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue". Nucleic Acids Res. 25 (5): 1028–35. doi:10.1093/nar/25.5.1028. PMC   146536 . PMID   9102632.
• Huang Y, Deng T, Winston BW (2000). "Characterization of hPRP4 kinase activation: potential role in signaling". Biochem. Biophys. Res. Commun. 271 (2): 456–63. doi:10.1006/bbrc.2000.2651. PMID   10799319.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC   1370266 . PMID   11991638.
• Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. PMC   139773 . PMID   12077342.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Bennett EM, Lever AM, Allen JF (2004). "Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2". J. Virol. 78 (20): 11303–12. doi:10.1128/JVI.78.20.11303-11312.2004. PMC   521795 . PMID   15452250.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi: 10.1074/mcp.M500089-MCP200 . PMID   15951569.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC   2674583 . PMID   17513757.