PRPF4

PRPF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MZW, 3JCR
Identifiers
Aliases	PRPF4 , HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60, pre-mRNA processing factor 4
External IDs	OMIM: 607795; MGI: 1917302; HomoloGene: 3446; GeneCards: PRPF4; OMA:PRPF4 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q32 Start 113,275,642 bp [1] End 113,294,009 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 B3 Start 62,327,034 bp [2] End 62,345,227 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte corpus epididymis cartilage tissue endothelial cell islet of Langerhans tail of epididymis caput epididymis embryo Skeletal muscle tissue of biceps brachii ventricular zone Top expressed in hand maxillary prominence epiblast mandibular prominence foot yolk sac interventricular septum primitive streak cumulus cell superior cervical ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function U4 snRNA binding protein binding U6 snRNA binding Cellular component Cajal body nuclear speck spliceosomal complex spliceosomal snRNP complex U4/U6 snRNP nucleoplasm U4/U6 x U5 tri-snRNP complex nucleus U2-type precatalytic spliceosome Biological process RNA splicing, via transesterification reactions mRNA processing RNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9128 70052 Ensembl ENSG00000136875 ENSMUSG00000066148 UniProt O43172 Q9DAW6 RefSeq (mRNA) NM_001244926 NM_004697 NM_001322266 NM_001322267 NM_027297 RefSeq (protein) NP_001231855 NP_001309195 NP_001309196 NP_004688 NP_081573 Location (UCSC) Chr 9: 113.28 – 113.29 Mb Chr 4: 62.33 – 62.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that is found in humans and encoded by the PRPF4 gene. ^{[5] [6] [7]}

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors.

PRPF4 is 1 of several proteins that associates with U4 and U6 snRNPs.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000136875 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000066148 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lauber J, Plessel G, Prehn S, Will CL, Fabrizio P, Groning K, Lane WS, Luhrmann R (Sep 1997). "The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p". RNA. 3 (8): 926–41. PMC   1369537 . PMID   9257651.
6. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC   1369579 . PMID   9404889.
7. "Entrez Gene: PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Horowitz DS, Krainer AR (1997). "A human protein required for the second step of pre-mRNA splicing is functionally related to a yeast splicing factor". Genes Dev. 11 (1): 139–51. doi: 10.1101/gad.11.1.139 . PMID   9000057.
• Wang A, Forman-Kay J, Luo Y, et al. (1997). "Identification and characterization of human genes encoding Hprp3p and Hprp4p, interacting components of the spliceosome". Hum. Mol. Genet. 6 (12): 2117–26. doi: 10.1093/hmg/6.12.2117 . PMID   9328476.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Heng HH, Wang A, Hu J (1998). "Mapping of the human HPRP3 and HPRP4 genes encoding U4/U6-associated splicing factors to chromosomes 1q21.1 and 9q31-q33". Genomics. 48 (2): 273–5. doi:10.1006/geno.1997.5181. PMID   9521884.
• Kojima T, Zama T, Wada K, et al. (2001). "Cloning of human PRP4 reveals interaction with Clk1". J. Biol. Chem. 276 (34): 32247–56. doi: 10.1074/jbc.M103790200 . PMID   11418604.
• Gonzalez-Santos JM, Wang A, Jones J, et al. (2002). "Central region of the human splicing factor Hprp3p interacts with Hprp4p". J. Biol. Chem. 277 (26): 23764–72. doi: 10.1074/jbc.M111461200 . PMID   11971898.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Reidt U, Wahl MC, Fasshauer D, et al. (2003). "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide" (PDF). J. Mol. Biol. 331 (1): 45–56. doi:10.1016/S0022-2836(03)00684-3. hdl: 11858/00-001M-0000-0012-F239-9 . PMID   12875835.
• Ingelfinger D, Göthel SF, Marahiel MA, et al. (2004). "Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH". Nucleic Acids Res. 31 (16): 4791–6. doi:10.1093/nar/gkg660. PMC   169899 . PMID   12907720.
• Stanĕk D, Neugebauer KM (2004). "Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer". J. Cell Biol. 166 (7): 1015–25. doi:10.1083/jcb.200405160. PMC   2172029 . PMID   15452143.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Liu S, Rauhut R, Vornlocher HP, Lührmann R (2006). "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP". RNA. 12 (7): 1418–30. doi:10.1261/rna.55406. PMC   1484429 . PMID   16723661.
• Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC   2674583 . PMID   17513757.