PLRG1

PLRG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4YVD
Identifiers
Aliases	PLRG1 , Cwc1, PRL1, PRP46, PRPF46, TANGO4, pleiotropic regulator 1
External IDs	OMIM: 605961; MGI: 1858197; HomoloGene: 2004; GeneCards: PLRG1; OMA:PLRG1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q31.3 Start 154,535,005 bp [1] End 154,550,400 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 E3 Start 82,962,829 bp [2] End 82,979,662 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon islet of Langerhans smooth muscle tissue body of uterus left lobe of thyroid gland palpebral conjunctiva right lobe of thyroid gland rectum right uterine tube Top expressed in primitive streak primary oocyte maxillary prominence mandibular prominence medial ganglionic eminence endocardial cushion somite abdominal wall epiblast superior cervical ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component DNA replication factor A complex Cul4-RING E3 ubiquitin ligase complex catalytic step 2 spliceosome nuclear membrane spliceosomal complex precatalytic spliceosome Prp19 complex fibrillar center nucleoplasm nuclear speck U2-type catalytic step 2 spliceosome nucleus Biological process protein localization to nucleus positive regulation of G1/S transition of mitotic cell cycle mRNA processing RNA splicing mRNA splicing, via spliceosome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5356 53317 Ensembl ENSG00000171566 ENSMUSG00000027998 UniProt O43660 Q922V4 RefSeq (mRNA) NM_002669 NM_001201564 NM_016784 RefSeq (protein) NP_001188493 NP_002660 NP_058064 Location (UCSC) Chr 4: 154.54 – 154.55 Mb Chr 3: 82.96 – 82.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Pleiotropic regulator 1 is a protein that in humans is encoded by the PLRG1 gene. ^[5]

Interactions

PLRG1 has been shown to interact with CDC5L. ^{[6] [7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000171566 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027998 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PLRG1 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)".
6. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
7. Ajuh P, Lamond AI (November 2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC   275459 . PMID   14576297.
8. Ajuh P, Sleeman J, Chusainow J, Lamond AI (November 2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi: 10.1074/jbc.M105453200 . ISSN   0021-9258. PMID   11544257.
9. Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.

Further reading

• Németh K, Salchert K, Putnoky P, et al. (1998). "Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis". Genes Dev. 12 (19): 3059–73. doi:10.1101/gad.12.19.3059. PMC   317193 . PMID   9765207.
• Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC   305846 . PMID   11101529.
• Ajuh P, Sleeman J, Chusainow J, Lamond AI (2001). "A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing". J. Biol. Chem. 276 (45): 42370–81. doi: 10.1074/jbc.M105453200 . PMID   11544257.
• Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC   186633 . PMID   12176931.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ajuh P, Lamond AI (2003). "Identification of peptide inhibitors of pre-mRNA splicing derived from the essential interaction domains of CDC5L and PLRG1". Nucleic Acids Res. 31 (21): 6104–16. doi:10.1093/nar/gkg817. PMC   275459 . PMID   14576297.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.