Dyssynergia

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Dyssynergia

Dyssynergia is any disturbance of muscular coordination, resulting in uncoordinated and abrupt movements. This is also an aspect of ataxia. [1] It is typical for dyssynergic patients to split a movement into several smaller movements. Types of dyssynergia include Ramsay Hunt syndrome type 1, bladder sphincter dyssynergia, and anal sphincter dyssynergia.

Contents

Dyssynergia can be caused by disruption or damage between the cerebellum and the sacral spinal cord. Damage to the spinal cord can be caused by injury or acquired through hereditary means such as myelodysplasia. Other hereditary means of dyssynergia can be from multiple sclerosis and various manifestations of transverse myelitis.

In addition, most brain damage to the cerebellum will cause dyssynergia. The cerebellum is split into three separate parts: the archicerebellum (controls equilibrium and helps to move the eye, head and neck), midline vermis (helps to move lower body), and lateral hemisphere (control of arms and quick movements). Damage to any part of the cerebellum can cause a disconnect between nerve cells and muscles, causing impaired muscle coordination.

Types

Ramsay Hunt syndrome type 1

Ramsay Hunt syndrome type 1 is a rare, neurodegenerative disorder characterized by myoclonus, intention tremor, progressive ataxia and occasionally dementia. [2] [3]

Bladder sphincter dyssynergia

Bladder sphincter dyssynergia also known as detrusor sphincter dyssynergia is the decrease of detrusor (wall muscle of the bladder) pressure which causes unwanted urination. This is very common in spinal cord injuries and multiple sclerosis patients. There is a malfunction between the central nervous system, urinary sphincters, and detrusor muscles. [4] A condition with similar symptoms but different causes is Pseudodyssynergia.

Anal sphincter dyssynergia

Anal sphincter dyssynergia also known as pelvic floor dyssynergia is the weakening of the pelvic floor or sphincters in the anus. The pelvic floor are the muscles that attach to the pelvis in the abdomen. Anal sphincter dyssynergia can be caused by obstructions, but mostly improper relaxing of the anal sphincters or pelvic floor muscle during defecation. Also if there is a decrease in intrarectal pressure defecation can occur. [5]

Diagnosis

Anal sphincter dyssynergia

Anal sphincter dyssynergia tends to be one of the most predicted diagnoses with a patient suffering from symptoms like chronic constipation and inability to control bowel movements. Diagnosis techniques for dyssynergia have been known to be expensive and aren’t commonly offered at some countrywide hospitals. Fortunately, there are still special tests and examinations that can be done given the proper medical care and treatment to properly detect and diagnose dyssynergia. Those following treatments include: anorectal manometry (balloon expulsion test and anal sphincter EMG), defecography studies, and digital rectal examinations (DRE). [6]

Anorectal manometry

Anorectal manometry involves two separate tests: the balloon expulsion test and anal sphincter electromyography (EMG). These tests are performed in order to properly identify and diagnose dyssynergia. In order to prepare for these tests, a patient must fast and perform specific enemas recommended by their doctor two hours before their tests. When undergoing the balloon expulsion test, the patient has a small balloon inserted into their rectum, which is then inflated and filled with water. The patient is then instructed to go to the nearest bathroom and to attempt to defecate the balloon, where the time it takes is recorded by the doctors. An abnormal or prolonged time of expulsion of the balloon is seen as a problem in the anorectum region of the body and may lead to the diagnosis of dyssynergia, since the patient has a lack of control over their anorectal muscle contractions. Another technique used by doctors to test for dyssynergia is the anal sphincter EMG. This test involves the insertion of an electrode into the patient’s anal cavity, where they are asked to relax and push, as if they are trying to defecate. The electrical activity and contractile pressures of the patient’s anorectal contractions are recorded on a computer monitor and examined by the doctor. If the electrical activity of the contractions appear normal, but the patient still results in constipation, it would indicate that there is a problem in the muscle activity or that there might be a tear in the muscle. This can help lead to a diagnosis of dyssynergia or an alternative surgical cure. [7]

Defecography studies

In defecography studies, doctors take an X-Ray of the patient and examine their rectum as it empties during defecation. Before the examination, patients are instructed to drink barium an hour before the examination. Barium paste is then inserted into the rectal and anal cavity, and for female patients X-Ray dye is placed on the urinary bladder and in the vagina. The barium is used so that the digestive tract, such as the intestines, rectal cavity, and anal cavity can be seen clearly on the X-Ray and the muscle movements can be examined by doctors. [8]

Digital rectal examinations

During a digital rectal examinations (DRE), a doctor will wear a lubricated latex glove and gently insert one finger, or digit, into the patient’s anus to perform a physical examination of the lower pelvic regions. This test is traditionally used for men to check the prostate gland for any abnormal bumps or growths, and for women to check the uterus and ovaries. This test can help identify complications that may be causing abnormal bowel habits, which can help properly diagnose cases of dyssynergia. [9]

Treatment

Bladder sphincter dyssynergia

Medication

Alpha blockers have been studied when treating people with detrusor sphincter dyssynergia (DSD). Terazosin has shown no reduction in voiding pressures with people who have suffered from spinal cord injuries, while Tamsulosin was given to patients with MS and resulted in improvement of post void residual measurements. However, it is not advised to use alpha blockers due to the lack of data supporting their success. Anti-spasmodic medications have also been tested on people with DSD. Oral Baclofen has limited benefit in treating DSD because it has low permeability across the blood brain barrier. [10]

Diagram of coronary angioplasty and stent placement. Urethral stent is similar to that used in heart. PTCA stent NIH.gif
Diagram of coronary angioplasty and stent placement. Urethral stent is similar to that used in heart.

Catheterization

Intermittent catheters are used most frequently to treat DSD. The catheter is able to be inserted and removed from a person's bladder several times a day, so it is not permanently installed. This is to help people who struggle to empty their bladder. It is recommended that a person does not empty their bladder until a catheter is installed and stabilized. By having the catheter, the goal is to help reduce spasms within the sphincter. Ultrasound can be used to help track how effective the use of the catheter is. If a person struggles with using an intermittent catheter, than an indwelling catheter can be used instead. The indwelling has the same function, however it is designed to remain in the bladder. [10]

Botox

Botulinum A Toxin (BTX A) is injected into the external sphincter via cystoscopic or ultrasound. Botox blocks the release of acetylcholine, a neurotransmitter that is needed for muscle contraction. With the release of acetylcholine inhibited, muscles will become more relaxed. [10]

Urethral stents

Urethral stents are thin wires that are placed within the urethra to either treat or prevent obstruction of urine flowing from the kidney. The stents can either be placed temporarily or permanently. [10]

Sphincterotomy

Sphincterotomy is the most invasive treatment to use when treating DSD. The purpose of the treatment is to create a low pressure within the bladder as well as impair the external sphincter. Electrocautery is used to cut out the external sphincter, which can result in a lot of bleeding. A catheter is then used to help relieve pressure that can occur. [10] [11]

See also

Related Research Articles

<span class="mw-page-title-main">Pudendal nerve</span> Main nerve of the perineum

The pudendal nerve is the main nerve of the perineum. It carries sensation from the external genitalia of both sexes and the skin around the anus and perineum, as well as the motor supply to various pelvic muscles, including the male or female external urethral sphincter and the external anal sphincter. If damaged, most commonly by childbirth, lesions may cause sensory loss or fecal incontinence. The nerve may be temporarily blocked as part of an anaesthetic procedure.

<span class="mw-page-title-main">Constipation</span> Bowel dysfunction

Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. The stool is often hard and dry. Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. Complications from constipation may include hemorrhoids, anal fissure or fecal impaction. The normal frequency of bowel movements in adults is between three per day and three per week. Babies often have three to four bowel movements per day while young children typically have two to three per day.

<span class="mw-page-title-main">Urinary incontinence</span> Uncontrolled leakage of urine

Urinary incontinence (UI), also known as involuntary urination, is any uncontrolled leakage of urine. It is a common and distressing problem, which may have a large impact on quality of life. It has been identified as an important issue in geriatric health care. The term enuresis is often used to refer to urinary incontinence primarily in children, such as nocturnal enuresis. UI is an example of a stigmatized medical condition, which creates barriers to successful management and makes the problem worse. People may be too embarrassed to seek medical help, and attempt to self-manage the symptom in secrecy from others.

<span class="mw-page-title-main">Fecal incontinence</span> Inability to refrain from defecation

Fecal incontinence (FI), or in some forms encopresis, is a lack of control over defecation, leading to involuntary loss of bowel contents, both liquid stool elements and mucus, or solid feces. When this loss includes flatus (gas), it is referred to as anal incontinence. FI is a sign or a symptom, not a diagnosis. Incontinence can result from different causes and might occur with either constipation or diarrhea. Continence is maintained by several interrelated factors, including the anal sampling mechanism, and incontinence usually results from deficiency of multiple mechanisms. The most common causes are thought to be immediate or delayed damage from childbirth, complications from prior anorectal surgery, altered bowel habits, and receptive anal sex. An estimated 2.2% of community dwelling adults are affected. However, reported prevalence figures vary. A prevalence of 8.39% among non-institutionalized U.S adults between 2005 and 2010 has been reported, and among institutionalized elders figures come close to 50%.

<span class="mw-page-title-main">Rectal prolapse</span> Medical condition

A rectal prolapse occurs when walls of the rectum have prolapsed to such a degree that they protrude out of the anus and are visible outside the body. However, most researchers agree that there are 3 to 5 different types of rectal prolapse, depending on whether the prolapsed section is visible externally, and whether the full or only partial thickness of the rectal wall is involved.

<span class="mw-page-title-main">Urinary retention</span> Inability to completely empty the bladder

Urinary retention is an inability to completely empty the bladder. Onset can be sudden or gradual. When of sudden onset, symptoms include an inability to urinate and lower abdominal pain. When of gradual onset, symptoms may include loss of bladder control, mild lower abdominal pain, and a weak urine stream. Those with long-term problems are at risk of urinary tract infections.

<span class="mw-page-title-main">Suprapubic cystostomy</span>

A suprapubic cystostomy or suprapubic catheter (SPC) is a surgically created connection between the urinary bladder and the skin used to drain urine from the bladder in individuals with obstruction of normal urinary flow. The connection does not go through the abdominal cavity.

<span class="mw-page-title-main">Bladder sphincter dyssynergia</span> Medical condition

Bladder sphincter dyssynergia is a consequence of a neurological pathology such as spinal injury or multiple sclerosis which disrupts central nervous system regulation of the micturition (urination) reflex resulting in dyscoordination of the detrusor muscles of the bladder and the male or female external urethral sphincter muscles. In normal lower urinary tract function, these two separate muscle structures act in synergistic coordination. But in this neurogenic disorder, the urethral sphincter muscle, instead of relaxing completely during voiding, dyssynergically contracts causing the flow to be interrupted and the bladder pressure to rise.

Neurogenic bladder dysfunction, or neurogenic bladder, refers to urinary bladder problems due to disease or injury of the central nervous system or peripheral nerves involved in the control of urination. There are multiple types of neurogenic bladder depending on the underlying cause and the symptoms. Symptoms include overactive bladder, urinary urgency, frequency, incontinence or difficulty passing urine. A range of diseases or conditions can cause neurogenic bladder including spinal cord injury, multiple sclerosis, stroke, brain injury, spina bifida, peripheral nerve damage, Parkinson's disease, or other neurodegenerative diseases. Neurogenic bladder can be diagnosed through a history and physical as well as imaging and more specialized testing. Treatment depends on underlying disease as well as symptoms and can be managed with behavioral changes, medications, surgeries, or other procedures. The symptoms of neurogenic bladder, especially incontinence, can have a significant impact on quality of life.

<span class="mw-page-title-main">Defecography</span> Visualisation of the mechanics of a patients defecation

Defecography is a type of medical radiological imaging in which the mechanics of a patient's defecation are visualized in real time using a fluoroscope. The anatomy and function of the anorectum and pelvic floor can be dynamically studied at various stages during defecation.

<span class="mw-page-title-main">Rectum</span> Final portion of the large intestine

The rectum is the final straight portion of the large intestine in humans and some other mammals, and the gut in others. The adult human rectum is about 12 centimetres (4.7 in) long, and begins at the rectosigmoid junction at the level of the third sacral vertebra or the sacral promontory depending upon what definition is used. Its diameter is similar to that of the sigmoid colon at its commencement, but it is dilated near its termination, forming the rectal ampulla. It terminates at the level of the anorectal ring or the dentate line, again depending upon which definition is used. In humans, the rectum is followed by the anal canal which is about 4 centimetres (1.6 in) long, before the gastrointestinal tract terminates at the anal verge. The word rectum comes from the Latin rectumintestinum, meaning straight intestine.

<span class="mw-page-title-main">Urodynamic testing</span> Assessment of bladder and urethra performance

Urodynamic testing or urodynamics is a study that assesses how the bladder and urethra are performing their job of storing and releasing urine. Urodynamic tests can help explain symptoms such as:

Rectal pain is the symptom of pain in the area of the rectum. A number of different causes (68) have been documented.

<span class="mw-page-title-main">Overflow incontinence</span> Medical condition

Overflow incontinence is a concept of urinary incontinence, characterized by the involuntary release of urine from an overfull urinary bladder, often in the absence of any urge to urinate. This condition occurs in people who have a blockage of the bladder outlet, or when the muscle that expels urine from the bladder is too weak to empty the bladder normally. Overflow incontinence may also be a side effect of certain medications.

<span class="mw-page-title-main">Anorectal manometry</span> Medical functional test of the anus and rectum

Anorectal manometry(ARM) is a medical test used to measure pressures in the anus and rectum and to assess their function. The test is performed by inserting a catheter, that contains a probe embedded with pressure sensors, through the anus and into the rectum. Patients may be asked to perform certain maneuvers, such as coughing or attempting to defecate, to assess for pressure changes. Anorectal manometry is a safe and low risk procedure.

<span class="mw-page-title-main">Anismus</span> Medical condition

Anismus or dyssynergic defecation is the failure of normal relaxation of pelvic floor muscles during attempted defecation. It can occur in both children and adults, and in both men and women. It can be caused by physical defects or it can occur for other reasons or unknown reasons. Anismus that has a behavioral cause could be viewed as having similarities with parcopresis, or psychogenic fecal retention.

Obstructed defecation is "difficulty in evacuation or emptying the rectum [which] may occur even with frequent visits to the toilet and even with passing soft motions". The conditions that can create the symptom are sometimes grouped together as defecation disorders. The symptom tenesmus is a closely related topic.

Descending perineum syndrome refers to a condition where the perineum "balloons" several centimeters below the bony outlet of the pelvis during strain, although this descent may happen without straining. The syndrome was first described in 1966 by Parks et al.

In fecal incontinence (FI), surgery may be carried out if conservative measures alone are not sufficient to control symptoms. There are many surgical options described for FI, and they can be considered in 4 general groups.

<span class="mw-page-title-main">Neurogenic bowel dysfunction</span> Human disease involving inability to control defecation

Neurogenic bowel dysfunction (NBD) is the inability to control defecation due to a deterioration of or injury to the nervous system, resulting in faecal incontinence or constipation. It is common in people with spinal cord injury (SCI), multiple sclerosis (MS) or spina bifida.

References

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  2. "Ramsay Hunt Syndrome". Archived from the original on 2011-08-28. Retrieved 2011-05-12.
  3. "National Institute of Neurological Disorders and Stroke". February 14, 2011. Archived from the original on February 16, 2015. Retrieved 2011-05-12.
  4. Stoffel, John (February 5, 2016). "Detrusor Sphincter Dyssynergia: a Review of Physiology, Diagnosis, and Treatment Strategies". Translational Andrology and Urology. 5 (1): 127–135. doi:10.3978/j.issn.2223-4683.2016.01.08. PMC   4739973 . PMID   26904418.
  5. Seong, Moo-Kwung; Kim, Tae-Won (March 26, 2013). "Significance of defecographic parameters in diagnosing pelvic floor dyssynergia". Journal of the Korean Surgical Society. 84 (4): 225–230. doi:10.4174/jkss.2013.84.4.225. PMC   3616276 . PMID   23577317.
  6. Tantphlachiva, Kasaya; Priyanka, Rao; Rao, Satish (November 2010). "Digital Rectal Examination Is a Useful Tool for Identifying Patients With Dyssynergia". Clinical Gastroenterology and Hepatology. 8 (11): 955–960. doi:10.1016/j.cgh.2010.06.031. PMID   20656061 . Retrieved March 30, 2016.
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  8. "Defecography". MUSC Health. Medical University of South Carolina. Archived from the original on March 18, 2016. Retrieved March 30, 2016.
  9. Staller, Kyle (2015-09-07). "Role of Anorectal Manometry in Clinical Practice". Current Treatment Options in Gastroenterology. 13 (4): 418–431. doi:10.1007/s11938-015-0067-6. ISSN   1092-8472. PMID   26343222. S2CID   23498678.
  10. 1 2 3 4 5 Stoffel, John (Feb 2016). "Detrusor sphincter dyssynergia: a review of physiology, diagnosis, and treatment strategies". Translational Andrology and Urology. 5: 127–135. doi:10.3978/j.issn.2223-4683.2016.01.08. PMC   4739973 . PMID   26904418.
  11. Reynard, J M; Vass, J; Sullivan, M E; Mamas, M (2003). "Sphincterotomy and the treatment of detrusor–sphincter dyssynergia: current status, future prospects". Spinal Cord. 41 (1): 1–11. doi: 10.1038/sj.sc.3101378 . PMID   12494314.