HLA-B17

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HLA-B17 (B17) is an HLA - B serotype. B17 is a broad antigen serotype that recognizes the B57 and B58 split antigen serotypes. [1] B17 is still encountered in the current literature, although most studies now use B57/B58 or gene typing designators. Both serotypes are involved in slightly different drug-sensitive diseases.

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<span class="mw-page-title-main">HLA-A1</span> Human leukocyte antigen serotype

HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*01:01. A1 and A*01 are almost synonymous in meaning. A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. A1 is a frequent component of the AH8.1 haplotype. A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype.

<span class="mw-page-title-main">HLA-A33</span> Human leukocyte antigen serotype

HLA-A33 (A33) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α33 subset of HLA-A α-chains. For A33, the alpha "A" chain are encoded by the HLA-A*33 allele group and the β-chain are encoded by B2M locus. A33 and A*33 are almost synonymous in meaning. A33 is a split antigen of the broad antigen serotype A19. A33 is a sister serotype of A29, A30, A31, A32, and A74.

<span class="mw-page-title-main">HLA-B81</span> Human leukocyte antigen serotype

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span> Human leukocyte antigen serotype

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

<span class="mw-page-title-main">HLA-B12</span> Human leukocyte antigen serotype

HLA-B12 (B12) is an HLA-B serotype. B12 is a broad antigen serotype that recognizes the B44 and B45 split antigen serotypes.

<span class="mw-page-title-main">HLA-B16</span> Human leukocyte antigen serotype

HLA-B16 (B16) is an HLA - B serotype. B16 is a broad antigen serotype that recognizes the B38 and B39 split antigen serotypes.

HLA-B21 (B21) is an HLA - B serotype. B21 is a broad antigen serotype that recognizes the B49 and B50 split antigen serotypes.

HLA-B22 (B22) is an HLA - B serotype. B22 is a broad antigen serotype that recognizes the B54, B55, and B56 split antigen serotypes.

<span class="mw-page-title-main">HLA-B14</span> Human leukocyte antigen serotype

HLA-B14 (B14) is a HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B58</span> Human leukocyte antigen serotype

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.

<span class="mw-page-title-main">HLA-B57</span> Human leukocyte antigen serotype

HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype being B58. The serotype identifies the more common HLA-B*57 gene products. Like B58, B57 is involved in drug-induced inflammatory skin disorders.

<span class="mw-page-title-main">HLA-B75</span> Human leukocyte antigen serotype

HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
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