HLA-B18

Last updated
major histocompatibility complex (human), class I, B18
AllelesB*1801
AllelesB*1802
AllelesB*1803
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*1801
EBI-HLA B*1802
EBI-HLA B*1803
Locus chr.6 6p21.31

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. [1] (For terminology help see: HLA-serotype tutorial) B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

Contents

Serotype

B*18:06 is one of the four B alleles that reacts with neither Bw4 nor Bw6. The others are B*46:01, B*55:03, and B*73:01. [2]

B18 serotype recognition of Some HLA B*18 allele-group gene products [3]
B*18B18Sample
allele % %size (N)
1801961641
18029031
18038329

Allele frequencies

HLA B*1801 frequencies
freq
ref.Population(%)
[4] Italy North pop 116.7
[4] Croatia11.3
[4] Georgia Svaneti Svans11.3
[4] Romanian11.3
[4] Portugal South11.2
[4] Singapore Riau Malay9.9
[4] Bulgaria9.1
[4] Israel Arab Druse8.5
[4] Azores Central Islands8.0
[4] Portugal Centre8.0
[4] Finland7.8
[4] Azores Santa Maria and Sao Miguel7.7
[4] Czech Republic7.5
[4] India Jalpaiguri Toto7.5
[4] Iran Baloch7.1
[4] Philippines Ivatan7.0
[4] Thailand6.7
[4] Tunisia6.7
[4] Portugal North6.5
[4] Zimbabwe Harare Shona6.4
[4] Madeira6.2
[4] Mexico Mestizos6.1
[4] Kenya5.9
[4] Belgium5.1
[4] Morocco Nador Metalsa Class I5.1
[4] Singapore Javanese Indonesians5.1
[4] Israel Ashkenazi and Non Ashkenazi Jews5.0
[4] Uganda Kampala5.0
[4] Kenya Nandi4.8
[4] Oman4.7
[4] Georgia Tbilisi Georgians4.6
[4] Bulgaria Gipsy4.5
[4] France South East4.3
[4] Kenya Luo4.3
[4] Ireland South4.2
[4] Russia Arkhangelsk Pomors4.0
[4] Azores Terceira Island3.9
[4] Guinea Bissau3.8
[4] India New Delhi3.8
[4] Spain Eastern Andalusia Gipsy3.5
[4] Australia New South Wales3.4
[4] Georgia Tbilisi Kurds3.4
[4] Zambia Lusaka3.4
[4] Cameroon Yaounde2.7
[4] Senegal Niokholo Mandenka2.7
[4] Cameroon Beti2.3
[4] Ivory Coast Akan Adiopodoume2.3
[4] Sudanese2.3
[4] Saudi Arabia Guraiat and Hail2.2
[4] South African Natal Zulu2.0
[4] Thailand2.0
[4] India Mumbai Marathas1.9
[4] New Caledonia1.9
[4] Papua New Guinea Wanigela1.5
[4] Cameroon Bamileke1.3

Related Research Articles

<span class="mw-page-title-main">HLA-A69</span>

HLA-A69 (A69) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α69 subset of HLA-A α-chains. For A69, the alpha "A" chain are encoded by the HLA-A*69 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*6901. A69 and A*69 are almost synonymous in meaning. A69 is a split antigen of the broad antigen serotype A28. A69 is a sister serotype of A68.

<span class="mw-page-title-main">HLA-B*82</span>

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product. Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes. B73 is more common in Western Indian Ocean, Mediterranean and Africa.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif, indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence.

HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele. B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma. B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span>

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B51</span> Serotype

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

<span class="mw-page-title-main">HLA-B38</span>

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

<span class="mw-page-title-main">HLA-B63</span>

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. Voorter, CE; van der Vlies, S; Kik, M; van den Berg-Loonen, EM (October 2000). "Unexpected Bw4 and Bw6 reactivity patterns in new alleles". Tissue Antigens. 56 (4): 363–70. doi:10.1034/j.1399-0039.2000.560409.x. PMID   11098937.
  3. derived from IMGT/HLA
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.