B*5101-β2MG with bound peptide 1e27 | ||
major histocompatibility complex (human), class I, B52 | ||
Alleles | B*5201, 5202, 5203, . . . | |
Structure (See HLA-B) | ||
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products. [1]
B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. [2] There are a number of alleles within the B*52 allele group. [3]
B*52 | B52 | B5 | B51 | B53 | Sample |
allele | % | % | % | % | size (N) |
*5201 | 84 | 2 | 7 | 1 | 2823 |
Alleles link-out to IMGT/HLA Databease at EBI |
freq | ||
ref. | Population | (%) |
[5] | China Yunnan Lisu | 21.7 |
[5] | China Yunnan Nu | 18.6 |
[5] | Bulgaria Gipsy | 18.2 |
[5] | Venezuela Sierra de Perija Yucpa | 12.8 |
[5] | India Andhra Pradesh Golla | 12.0 |
[5] | Japan Central | 10.7 |
[5] | Japan | 10.4 |
[5] | Georgia Tbilisi Kurds | 10.3 |
[5] | Mali Bandiagara | 8.3 |
[5] | South Africa Natal Tamil | 8.2 |
[5] | Israel Ashk. and Non-Ashk. Jews | 7.3 |
[5] | India North Hindus | 6.7 |
[5] | China Beijing | 6.1 |
[5] | India New Delhi | 6.1 |
[5] | India Mumbai Marathas | 5.6 |
[5] | Tunisia Ghannouch | 5.5 |
[5] | Thailand pop3 | 5.1 |
[5] | India West Coast Parsis | 5.0 |
[5] | India North Delhi | 4.9 |
[5] | Mexico Mestizos | 4.9 |
[5] | Argentina Toba Rosario | 4.7 |
[5] | Mexico Zaptotec Oaxaca | 4.5 |
[5] | USA Hispanic | 4.5 |
[5] | China Qinghai Hui | 4.1 |
[5] | China Inner Mongolia | 3.9 |
[5] | China North Han | 3.8 |
[5] | Oman | 3.8 |
[5] | Senegal Niokholo Mandenka | 3.7 |
[5] | Bulgaria | 3.6 |
[5] | Thailand | 3.5 |
[5] | Ivory Coast Akan Adiopodoume | 3.4 |
[5] | Venezuela Perja Mountain Bari | 3.4 |
[5] | Italy North pop 1 | 3.3 |
[5] | Sudanese | 3.3 |
[5] | Romanian | 3.2 |
[5] | Singapore Riau Malay | 3.0 |
[5] | Autonomous Region Tibetans | 2.8 |
[5] | Russia Tuva pop 2 | 2.8 |
[5] | South Korea pop 3 | 2.8 |
[5] | Iran Baloch | 2.5 |
[5] | Tunisia | 2.5 |
[5] | Jordan Amman | 2.4 |
[5] | USA Hawaii Okinawa | 2.4 |
[5] | Singapore Javanese Indonesians | 2.0 |
[5] | Spain Eastern Andalusia | 1.8 |
[5] | Macedonia pop 4 | 1.6 |
[5] | Uganda Kampala | 1.6 |
[5] | Belgium | 1.5 |
[5] | Mexico Guadalajara Mestizos pop2 | 1.5 |
[5] | Singapore Thai | 1.5 |
[5] | Brazil | 1.4 |
[5] | China Yunnan Lisu | 1.4 |
[5] | Azores Santa Maria and Sao Miguel | 1.3 |
[5] | France South East | 1.2 |
[5] | Italy North Pavia | 1.2 |
[5] | Saudi Arabia Guraiat and Hail | 1.2 |
[5] | Mexico Chihuahua State Tarahumara | 1.1 |
[5] | Tunisia Tunis | 1.1 |
[5] | Israel Arab Druse | 1.0 |
[5] | Japan Ainu Hokkaido | 1.0 |
[5] | Portugal Centre | 1.0 |
[5] | Singapore Chinese | 1.0 |
[5] | Taiwan Minnan pop 1 | 1.0 |
[5] | USA Caucasian | 1.0 |
[5] | Azores Central Islands | 0.9 |
[5] | China South Han | 0.9 |
[5] | Macedonia pop 4 | 0.7 |
[5] | Morocco Nador Metalsa Class I | 0.7 |
[5] | Georgia Svaneti Svans | 0.6 |
[5] | Ireland South | 0.6 |
[5] | Italy Bergamo | 0.6 |
There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.
HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. [6] [7] This form of disease is frequently found with Takayasu's arteritis. [8] [9]
Takayasu's arteritis appears to have an independent link to B52 associated disease. [10] [11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance. [12]
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.
HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α1 subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*01:01. A1 and A*01 are almost synonymous in meaning. A1 is more common in Europe than elsewhere, it is part of a long haplotype that appears to have been frequent in the ancient peoples of Northwestern Europe. A1 is a frequent component of the AH8.1 haplotype. A1 serotype positivity is roughly linked to a large number of inflammatory diseases and conditions believed to have immune system involvement. Because of its linkage within the AH8.1 haplotype many studies showed association with A1 or A1,B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. While it is not clear what role A1 has in infectious disease, some linkage with infection rates in HIV remain associated within the A1 region of the haplotype.
HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2.
HLA-A68 (A68) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α68 subset of HLA-A α-chains. For A68, the alpha "A" chain are encoded by the HLA-A*68 allele group and the β-chain are encoded by B2M locus. A68 and A*68 are almost synonymous in meaning. A68 is a split antigen of the broad antigen serotype A28. A68 is a sister serotype of A69.
HLA-B5 (B5) is an HLA-B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes.
HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.
HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.
HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.
HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele. B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma. B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels.
HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.
HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.
HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.
HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.
HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.
HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.
HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.
HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.
HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.
HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.