HLA-B52

Last updated
HLA-B.png
B*5101-β2MG with bound peptide 1e27 ​
major histocompatibility complex (human), class I, B52
AllelesB*5201, 5202, 5203, . . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products. [1]

Contents

B52 is a split antigen of the broad antigen B5, and is a sister type of B51. B*5201 likely formed as a result of a gene conversion event between another HLA-B allele and HLA-B*5101. [2] There are a number of alleles within the B*52 allele group. [3]

Serotype

Serotypes B52, B5, B51, and B53 recognition of HLA B*5201 gene product [4]
B*52B52B5B51B53Sample
allele % % % %size (N)
*5201842712823
Alleles link-out to IMGT/HLA Databease at EBI
HLA *5201 frequencies
freq
ref.Population(%)
[5] China Yunnan Lisu21.7
[5] China Yunnan Nu18.6
[5] Bulgaria Gipsy18.2
[5] Venezuela Sierra de Perija Yucpa12.8
[5] India Andhra Pradesh Golla12.0
[5] Japan Central10.7
[5] Japan10.4
[5] Georgia Tbilisi Kurds10.3
[5] Mali Bandiagara8.3
[5] South Africa Natal Tamil8.2
[5] Israel Ashk. and Non-Ashk. Jews7.3
[5] India North Hindus6.7
[5] China Beijing6.1
[5] India New Delhi6.1
[5] India Mumbai Marathas5.6
[5] Tunisia Ghannouch5.5
[5] Thailand pop35.1
[5] India West Coast Parsis5.0
[5] India North Delhi4.9
[5] Mexico Mestizos4.9
[5] Argentina Toba Rosario4.7
[5] Mexico Zaptotec Oaxaca4.5
[5] USA Hispanic4.5
[5] China Qinghai Hui4.1
[5] China Inner Mongolia3.9
[5] China North Han3.8
[5] Oman3.8
[5] Senegal Niokholo Mandenka3.7
[5] Bulgaria3.6
[5] Thailand3.5
[5] Ivory Coast Akan Adiopodoume3.4
[5] Venezuela Perja Mountain Bari3.4
[5] Italy North pop 13.3
[5] Sudanese3.3
[5] Romanian3.2
[5] Singapore Riau Malay3.0
[5] Autonomous Region Tibetans2.8
[5] Russia Tuva pop 22.8
[5] South Korea pop 32.8
[5] Iran Baloch2.5
[5] Tunisia2.5
[5] Jordan Amman2.4
[5] USA Hawaii Okinawa2.4
[5] Singapore Javanese Indonesians2.0
[5] Spain Eastern Andalusia1.8
[5] Macedonia pop 41.6
[5] Uganda Kampala1.6
[5] Belgium1.5
[5] Mexico Guadalajara Mestizos pop21.5
[5] Singapore Thai1.5
[5] Brazil1.4
[5] China Yunnan Lisu1.4
[5] Azores Santa Maria and Sao Miguel1.3
[5] France South East1.2
[5] Italy North Pavia1.2
[5] Saudi Arabia Guraiat and Hail1.2
[5] Mexico Chihuahua State Tarahumara1.1
[5] Tunisia Tunis1.1
[5] Israel Arab Druse1.0
[5] Japan Ainu Hokkaido1.0
[5] Portugal Centre1.0
[5] Singapore Chinese1.0
[5] Taiwan Minnan pop 11.0
[5] USA Caucasian1.0
[5] Azores Central Islands0.9
[5] China South Han0.9
[5] Macedonia pop 40.7
[5] Morocco Nador Metalsa Class I0.7
[5] Georgia Svaneti Svans0.6
[5] Ireland South0.6
[5] Italy Bergamo0.6

Alleles

There are 18 alleles, with 14 amino acid sequence variants in B52. Of these only 9 are frequent enough to have been reliably serotyped. B*5201 is the most common, but others have a large regional abundance.

Disease

In ulcerative colitis

HLA-B52 appears to have the strongest linkage to ulcerative colitis in Japan. [6] [7] This form of disease is frequently found with Takayasu's arteritis. [8] [9]

In Takayasu's arteritis

Takayasu's arteritis appears to have an independent link to B52 associated disease. [10] [11] The association with B*5201 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance. [12]

Related Research Articles

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR2</span> Antigen serotype

HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

<span class="mw-page-title-main">HLA-A*02</span> Human leukocyte antigen serotype within the HLA-A serotype group

HLA-A*02 (A*02) is a human leukocyte antigen serotype within the HLA-A serotype group. The serotype is determined by the antibody recognition of the α2 domain of the HLA-A α-chain. For A*02, the α chain is encoded by the HLA-A*02 gene and the β chain is encoded by the B2M locus. In 2010 the World Health Organization Naming Committee for Factors of the HLA System revised the nomenclature for HLAs. Before this revision, HLA-A*02 was also referred to as HLA-A2, HLA-A02, and HLA-A*2.

<span class="mw-page-title-main">HLA-B*82</span>

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B47 (B47) is an HLA–B serotype. The serotype identifies the HLA-B*47 gene products. Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event. B47 is linked to a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa.

HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele. B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma. B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels.

HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span> Human leukocyte antigen serotype

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B51</span> Serotype

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

<span class="mw-page-title-main">HLA-B39</span> Human leukocyte antigen serotype

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.

<span class="mw-page-title-main">HLA-B38</span> Human leukocyte antigen serotype

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

<span class="mw-page-title-main">HLA-B70</span> Human leukocyte antigen serotype

HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.

<span class="mw-page-title-main">HLA-B63</span> Human leukocyte antigen serotype

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ Cox ST, McWhinnie AJ, Robinson J, et al. (January 2003). "Cloning and sequencing full-length HLA-B and -C genes" (PDF). Tissue Antigens. 61 (1): 20–48. doi:10.1034/j.1399-0039.2003.610103.x. PMID   12622774. Archived from the original (PDF) on 2008-10-28. Retrieved 2008-08-03.
  3. ↑ Hayashi H, Ennis PD, Ariga H, et al. (January 1989). "HLA-B51 and HLA-Bw52 differ by only two amino acids which are in the helical region of the alpha 1 domain". J. Immunol. 142 (1): 306–11. PMID   2909619.
  4. ↑ derived from IMGT/HLA
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
  6. ↑ Sugimura K, Asakura H, Mizuki N, et al. (February 1993). "Analysis of genes within the HLA region affecting susceptibility to ulcerative colitis". Hum. Immunol. 36 (2): 112–8. doi:10.1016/0198-8859(93)90113-F. PMID   8096500.
  7. ↑ Nomura E, Kinouchi Y, Negoro K, et al. (September 2004). "Mapping of a disease susceptibility locus in chromosome 6p in Japanese patients with ulcerative colitis". Genes Immun. 5 (6): 477–83. doi:10.1038/sj.gene.6364114. PMID   15215890.
  8. ↑ Oyanagi, Hironobu; Ishihata, R; Ishikawa, H; et al. (February 1994), "Ulcerative colitis associated with Takayasu's disease", Intern. Med. , 33 (2): 127–129, doi: 10.2169/internalmedicine.33.127 , PMID   7912572
  9. ↑ Sato, R; Sato, Y; Ishikawa, H; et al. (December 1994), "Takayasu's disease associated with ulcerative colitis", Intern. Med. , 33 (12): 759–763, doi: 10.2169/internalmedicine.33.759 , PMID   7718956
  10. ↑ Kimura A, Kitamura H, Date Y, Numano F (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol. 54 Suppl: S61–9. doi:10.1016/s0167-5273(96)88774-2. PMID   9119528.
  11. ↑ Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens. 42 (2): 87–90. doi:10.1111/j.1399-0039.1993.tb02242.x. PMID   7903491.
  12. ↑ Kitamura H, Kobayashi Y, Kimura A, Numano F (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol. 66 Suppl 1: S121–6. doi:10.1016/S0167-5273(98)00159-4. PMID   9951811.
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