HLA-B50

Last updated
major histocompatibility complex (human), class I, B50
AllelesB*5001, B*5002,
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*5001
B*5002
Locus chr.6 6p21.31

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. [1] The serotype identifies the more common HLA-B*50 gene products. [2] (For terminology help see: HLA-serotype tutorial)

Contents

Serotype

B50 and B21 serotype recognition of some more common HLA B*50 alleles [3]
B*50B50B21Sample
allele % %size (N)
50018531700

The B*5002 by serotype definition is a B45 serotype. [4]

Allele distribution

HLA B*5001 frequencies
freq
ref.Population(%)
[5] Saudi Arabia Guraiat and Hail17.3
[5] Tunisia10.0
[5] Israel Arab Druse8.5
[5] Morocco Nador Metalsa (Berber)7.3
[5] Tunisia Tunis6.3
[5] Israel Ashkenazi and Non Ashkenazi Jews5.5
[5] Azores Terceira Island5.1
[5] Georgia Svaneti Svans3.8
[5] India North Delhi3.8
[5] Italy Bergamo3.6
[5] Georgia Tbilisi Kurds3.4
[5] Italy North (1)3.3
[5] Brazil Belo Horizonte3.2
[5] Madeira3.2
[5] Italy North Pavia3.1
[5] Portugal South3.1
[5] Oman3.0
[5] Georgia Tbilisi Georgians2.8
[5] Bulgaria2.7
[5] Azores Santa Maria and Sao Miguel2.6
[5] Spain Eastern Andalusia Gipsy2.5
[5] Sudanese2.5
[5] Czech Republic2.4
[5] Spain Eastern Andalusia2.4
[5] Spain Mallorca and Menorca2.2
[5] Burkina Faso Fulani2.0
[5] China Inner Mongolia2.0
[5] China North Han1.9
[5] India North Hindus1.9
[5] China Qinghai Hui1.8
[5] Jordan Amman1.7
[5] Russia Tuva (2)1.7
[5] Spain Catalonia Girona1.7
[5] Senegal Niokholo Mandenka1.6
[5] Guinea Bissau1.5
[5] India New Delhi1.5
[5] Croatia1.3
[5] Cuban Mulatto1.2
[5] France South East1.2
[5] Burkina Faso Rimaibe1.1
[5] Mali Bandiagara1.1
[5] Belgium1.0
[5] Ireland Northern1.0
[5] Ireland South1.0
[5] Italy Sardinia pop31.0
[5] South Africa Natal Tamil1.0
B*5002
[5] Morocco Nador Metalsa (Berber)4.3
[5] Portugal North1.1
[5] Portugal South1.0
[5] Madeira0.8
[5] Tunisia Tunis0.6

Related Research Articles

<span class="mw-page-title-main">HLA-B*82</span>

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.

<span class="mw-page-title-main">HLA-B81</span>

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product. Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes. B73 is more common in Western Indian Ocean, Mediterranean and Africa.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products. HLA-B*4201 is common in Central Africa.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span>

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-B21 (B21) is an HLA - B serotype. B21 is a broad antigen serotype that recognizes the B49 and B50 split antigen serotypes.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B70</span>

HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.

<span class="mw-page-title-main">HLA-B63</span>

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B62</span>

HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID   1385528.
  2. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  3. ↑ derived from IMGT/HLA
  4. ↑ Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens. 52 (2): 183–6. doi:10.1111/j.1399-0039.1998.tb02283.x. PMID   9756408.
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
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