HLA-B50

major histocompatibility complex (human), class I, B50
Alleles	B*5001, B*5002,
Structure (See HLA-B)
Symbol(s)	HLA-B
EBI-HLA	B*5001
	B*5002
Locus	chr.6 6p21.31

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. ^[1] The serotype identifies the more common HLA-B*50 gene products. ^[2] (For terminology help see: HLA-serotype tutorial)

Serotype

B50 and B21 serotype recognition of some more common HLA B*50 alleles ^[3]

B*50	B50	B21	Sample
allele	%	%	size (N)
5001	85	3	1700

The B*5002 by serotype definition is a B45 serotype. ^[4]

Allele distribution

HLA B*5001 frequencies

		freq
ref.	Population	(%)
[5]	Saudi Arabia Guraiat and Hail	17.3
[5]	Tunisia	10.0
[5]	Israel Arab Druse	8.5
[5]	Morocco Nador Metalsa (Berber)	7.3
[5]	Tunisia Tunis	6.3
[5]	Israel Ashkenazi and Non Ashkenazi Jews	5.5
[5]	Azores Terceira Island	5.1
[5]	Georgia Svaneti Svans	3.8
[5]	India North Delhi	3.8
[5]	Italy Bergamo	3.6
[5]	Georgia Tbilisi Kurds	3.4
[5]	Italy North (1)	3.3
[5]	Brazil Belo Horizonte	3.2
[5]	Madeira	3.2
[5]	Italy North Pavia	3.1
[5]	Portugal South	3.1
[5]	Oman	3.0
[5]	Georgia Tbilisi Georgians	2.8
[5]	Bulgaria	2.7
[5]	Azores Santa Maria and Sao Miguel	2.6
[5]	Spain Eastern Andalusia Gipsy	2.5
[5]	Sudanese	2.5
[5]	Czech Republic	2.4
[5]	Spain Eastern Andalusia	2.4
[5]	Spain Mallorca and Menorca	2.2
[5]	Burkina Faso Fulani	2.0
[5]	China Inner Mongolia	2.0
[5]	China North Han	1.9
[5]	India North Hindus	1.9
[5]	China Qinghai Hui	1.8
[5]	Jordan Amman	1.7
[5]	Russia Tuva (2)	1.7
[5]	Spain Catalonia Girona	1.7
[5]	Senegal Niokholo Mandenka	1.6
[5]	Guinea Bissau	1.5
[5]	India New Delhi	1.5
[5]	Croatia	1.3
[5]	Cuban Mulatto	1.2
[5]	France South East	1.2
[5]	Burkina Faso Rimaibe	1.1
[5]	Mali Bandiagara	1.1
[5]	Belgium	1.0
[5]	Ireland Northern	1.0
[5]	Ireland South	1.0
[5]	Italy Sardinia pop3	1.0
[5]	South Africa Natal Tamil	1.0
	B*5002
[5]	Morocco Nador Metalsa (Berber)	4.3
[5]	Portugal North	1.1
[5]	Portugal South	1.0
[5]	Madeira	0.8
[5]	Tunisia Tunis	0.6

References

1. Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID   1385528.
2. Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
3. derived from IMGT/HLA
4. Balas A, Santos S, García-Sánchez F, Lillo R, Merino L, Vicario JL (1998). "Characterization and distribution of HLA-B*5002 in a Spanish population sample". Tissue Antigens. 52 (2): 183–6. doi:10.1111/j.1399-0039.1998.tb02283.x. PMID   9756408.
5. Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.