HLA-B35

Last updated
HLA-B*3508.png
B*3508-β2MG with bound peptide
2h6p ​
major histocompatibility complex (human), class I, B35
AllelesB*3501, 3502, 3503, . . .
Structure (See HLA-B)
Symbol(s) HLA-B 2fyy ​, 2fz3 ​
EBI-HLA B*3501 2h6p ​, 2cik ​,
1a1n ​
EBI-HLA B*3502
EBI-HLA B*3503
EBI-HLA B*3504
EBI-HLA B*3505
EBI-HLA B*3506
EBI-HLA B*3507
EBI-HLA B*3508 2nw3 ​, 2nx5 ​
EBI-HLA B*3509
EBI-HLA B*3510
EBI-HLA B*3511
EBI-HLA B*3512
Locus chr.6 6p21.31

HLA-B35 (B35) is an HLA-B serotype. The serotype identifies the more common HLA-B*35 gene products. [1] B35 is one of the largest B serotype groups, it currently has 97 known nucleotide variants and 86 polypeptide isoforms. (For terminology help see: HLA-serotype tutorial). This variant is particularly susceptible to HIV infection.

Serotype

B35 serotype recognition of Some HLA B*35 allele-group gene products [2]
B*35B35Sample
allele % %size (N)
3501982023
3502721013
3503941226
350410026
350594231
35067910
350891349
3509683
35107512
35116717
351278422
35147929
35204223

Related Research Articles

<span class="mw-page-title-main">HLA-B81</span> Human leukocyte antigen serotype

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif, indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence.

HLA-B47 (B47) is an HLA–B serotype. The serotype identifies the HLA-B*47 gene products. Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event. B47 is linked to a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa.

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products. HLA-B*4201 is common in Central Africa.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B61 (B61) is an HLA - B serotype. B61 is a split antigen serotype that recognizes certain B40 serotypes.

HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span> Human leukocyte antigen serotype

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

<span class="mw-page-title-main">HLA-B16</span> Human leukocyte antigen serotype

HLA-B16 (B16) is an HLA - B serotype. B16 is a broad antigen serotype that recognizes the B38 and B39 split antigen serotypes.

HLA-B17 (B17) is an HLA - B serotype. B17 is a broad antigen serotype that recognizes the B57 and B58 split antigen serotypes. B17 is still encountered in the current literature, although most studies now use B57/B58 or gene typing designators. Both serotypes are involved in slightly different drug-sensitive diseases.

HLA-B21 (B21) is an HLA - B serotype. B21 is a broad antigen serotype that recognizes the B49 and B50 split antigen serotypes.

HLA-B22 (B22) is an HLA - B serotype. B22 is a broad antigen serotype that recognizes the B54, B55, and B56 split antigen serotypes.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ derived from IMGT/HLA
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