HLA-B38

Last updated
HLA-B.png
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B38
AllelesB*3801, 3802, . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus. [1]

Contents

B38 is a split antigen of the broad antigen B16, and is a sister type of B39. The B*3801 allele is more common in Eastern, Southern and Southeastern Europe, while the B*3802 allele is more common in the Far East.

Serotype

Serotypes B38, B16, and B39 recognition of the
HLA B*39 gene products [2]
B*38B38B16B39Sample
allele % % %size (N)
*380194112317
*38028722788
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

HLA B*3801 frequencies
freq
ref.Population(%)
[3] Israel Ashk. and Non Ashk. Jews6.9
Croatia6.7
Italy North6.7
Azores Central Islands5.4
Sudanese5.3
Czech Republic4.7
Georgia Tbilisi Georgians4.6
Macedonia (4)4.6
Spain Eastern Andalusia4.1
Georgia Svaneti Svans3.8
New Mexico Canoncito Navajo3.7
Bulgaria3.6
Brazil Belo Horizonte3.2
Romanian3.2
Tunisia3.0
Thailand2.8
Israel Arab Druse2.5
USA Caucasian (2)2.5
Tunisia Tunis2.3
Brazil2.2
Indig. Australian Cape York Penin.2.0
France South East1.9
Georgia Tbilisi Kurds1.7
Australia New South Wales1.5
China Guangzhou1.5
Mexico Guadalajara Mestizos (2)1.5
China Yunnan Lisu1.4
Jordan Amman1.4
Morocco Nador Metalsa Class I1.4
China South Han1.2
Mexico Mestizos1.2
Saudi Arabia Guraiat and Hail1.2
Finland1.1
USA North American Natives1.1
American Samoa1.0
China North Han1.0
India North Hindus1.0
Mexico Mixtec Oaxaca1.0
Hong Kong Chinese0.9
Ireland Northern0.9
Cape Verde Southeastern Islands0.8
China Beijing0.8
Ireland South0.8

Disease

A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma. [4] Psoriatic arthritis is linked to MICA and/or B39 in other peoples. [5] In Pemphigus vulgaris a haplotype containing B38 was identified and found to be shared between Spanish and Jewish patients. [6] Linkage studies indicate a factor in the HLA-class I region is more greatly associated, with HLA-B38 so far the only linked allele [7]

HLA B*3802 frequencies
freq
ref.Population(%)
[3] Taiwan Tao11.0
China Guangxi Maonan8.3
China South Han7.1
Singapore Javan. Indonesians7.1
Singapore Chinese Han6.4
Taiwan Minnan pop 16.4
China Guangzhou6.0
Philippines Ivatan6.0
Hong Kong Chinese5.4
Singapore Chinese4.7
Singapore Riau Malay4.5
China Guangzhou Han4.3
India West Bhils4.0
Taiwan Hakka3.6
Singapore Thai3.5
Taiwan Siraya2.9
Taiwan Pazeh1.8
India Mumbai Marathas1.2
South Korea pop 31.1
Taiwan Puyuma1.0
Taiwan Saisiat1.0
China Beijing0.8
Brazil0.7

Related Research Articles

HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. Certain HLA DR and DQ genes have known involvement in autoimmune diseases. DR3-DQ2, a multigene haplotype, stands out in prominence because it is a factor in several prominent diseases, namely coeliac disease and juvenile diabetes. In coeliac disease, the DR3-DQ2 haplotype is associated with highest risk for disease in first degree relatives, highest risk is conferred by DQA1*0501:DQB1*0201 homozygotes and semihomozygotes of DQ2, and represents the overwhelming majority of risk. HLA DR3-DQ2 encodes DQ2.5cis isoform of HLA-DQ, this isoform is described frequently as 'the DQ2 isoform', but in actuality there are two major DQ2 isoform. The DQ2.5 isoform, however, is many times more frequently associated with autoimmune disease, and as a result to contribution of DQ2.2 is often ignored.

<span class="mw-page-title-main">HLA-DQ4</span>

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.

<span class="mw-page-title-main">HLA-DQ6</span>

HLA-DQ6 (DQ6) is a human leukocyte antigen serotype within HLA-DQ (DQ) serotype group. The serotype is determined by the antibody recognition of β6 subset of DQ β-chains. The β-chain of DQ isoforms are encoded by HLA-DQB1 locus and DQ6 are encoded by the HLA-DQB1*06 allele group. This group currently contains many common alleles, DQB1*0602 is the most common. HLA-DQ6 and DQB1*06 are almost synonymous in meaning. DQ6 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. For DQ6, however, cis-isoform pairing only occurs with DQ1 α-chains. There are many haplotypes of DQ6.

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR16</span>

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

<span class="mw-page-title-main">HLA-DR15</span>

HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.

<span class="mw-page-title-main">HLA-DR5</span>

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

<span class="mw-page-title-main">HLA-DR1</span>

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.

<span class="mw-page-title-main">HLA-A69</span> Human leukocyte antigen serotype

HLA-A69 (A69) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α69 subset of HLA-A α-chains. For A69, the alpha "A" chain are encoded by the HLA-A*69 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*6901. A69 and A*69 are almost synonymous in meaning. A69 is a split antigen of the broad antigen serotype A28. A69 is a sister serotype of A68.

<span class="mw-page-title-main">HLA-A24</span> Human leukocyte antigen serotype

HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α24 subset of HLA-A α-chains. For A24, the alpha, "A", chain are encoded by the HLA-A*24 allele group and the β-chain are encoded by B2M locus. This group currently is dominated by A*2402. A24 and A*24 are almost synonymous in meaning. A24 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A23.

<span class="mw-page-title-main">HLA-B*82</span>

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

<span class="mw-page-title-main">HLA-B16</span> Human leukocyte antigen serotype

HLA-B16 (B16) is an HLA - B serotype. B16 is a broad antigen serotype that recognizes the B38 and B39 split antigen serotypes.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B51</span> Serotype

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

<span class="mw-page-title-main">HLA-B39</span> Human leukocyte antigen serotype

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products.

<span class="mw-page-title-main">HLA-B75</span> Human leukocyte antigen serotype

HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ derived from IMGT/HLA
  3. 1 2 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
  4. ↑ Imre K, Koó E, Seszták M, Bosák V, Bitterova O (December 2006). "[Genetics in patients with psoriatic arthritis]". Orv Hetil (in Hungarian). 147 (50): 2415–9. PMID   17274187.
  5. ↑ Eastmond CJ (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology. 8 (2): 263–76. doi:10.1016/S0950-3579(94)80018-9. PMID   8076387.
  6. ↑ Loewenthal R, Slomov Y, Gonzalez-Escribano MF, et al. (April 2004). "Common ancestral origin of pemphigus vulgaris in Jews and Spaniards: a study using microsatellite markers". Tissue Antigens. 63 (4): 326–34. doi:10.1111/j.0001-2815.2004.00191.x. PMID   15009804.
  7. ↑ Slomov E, Loewenthal R, Goldberg I, Korostishevsky M, Brenner S, Gazit E (August 2003). "Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers". Hum. Immunol. 64 (8): 771–9. doi:10.1016/S0198-8859(03)00092-2. PMID   12878355.
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