HLA-B62

Last updated
HLA B^1501.png
HLA-B62 with bound peptide
major histocompatibility complex (human), class I, B62
Alleles*1501, *1504, *1507, *1525
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. [1]

Contents

B62 is the largest of many split antigens of the broad antigen, B15. B62 best identifies the B*1501, B*1504, B*1507 B*1525 and B*1533 allele products.

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77
recognition of the HLA B*15 gene products [2]
B*15B15B62B63B70B71B72B75B76B77Sample
allele % % % % % % % % %size (N)
*1501 2961906
*1504 106929
*1505 186422
*1506 40201110
*1507 79101
*1508 201845
*1511 15272168
*1512 1718812
*1515 134928138
*1520 1005
*1524 4454
*1525 7748116
*1527 77676
*1528 1457147
*1530 176498
*1531 5012
*1535 7934
AlleleB15B62B63B70B71B72B75B76B77N
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

HLA B*1501 frequencies
freq
ref.Population(%)
[3] Japan Ainu Hokkaido29.0
Chihuahuan Tarahumara14.8
Autonomous Tibetans12.3
South Korea ( 3)10.5
Japan Central8.7
Japan pop37.5
USA North American Natives7.2
South Dakota Lakota Sioux7.1
Shijiazhuang Tianjian Han7.0
China Qinghai Hui6.8
Croatia6.7
Japan pop56.5
Portugal Centre6.0
Taiwan Rukai6.0
USA Alaska Yupik Natives5.8
Australia New South Wales5.6
USA European Americans (2)5.6
France South East5.5
China Beijing5.3
Czech Republic4.7
Ireland South4.6
Mexico Sonora Seri4.5
China Inner Mongolia4.4
Russia Tuva (2)4.2
Singapore Chinese4.0
Taiwan Paiwan3.9
China North Han3.8
Georgia Svaneti Svans3.8
Ireland Northern3.8
Italy North Pavia3.7
Mexico Mestizos3.7
Azores Central Islands3.6
Madeira3.5
Taiwan Minnan pop 13.4
Azores Terceira Island3.1
Taiwan Siraya2.9
USA Hispanic2.8
Taiwan Hakka2.7
Taiwan Pazeh2.7
China Yunnan Nu2.6
Uganda Kampala2.5
Argentina Toba Rosario2.3
Romanian2.3
Hong Kong Chinese2.2
India North Hindus1.9
New Caledonia1.9
Italy South Campania1.8
Taiwan Thao1.7
India North Delhi1.6
China Guangzhou1.5
China Guangxi Maonan1.4
China Yunnan Lisu1.4
Thailand1.4
PNG New Britain Rabaul1.3
Brazil Belo Horizonte1.1
Cameroon Yaounde1.1
Portugal North1.1
United Arab Emerates1.1
Thailand pop31.0
USA African America1.0
USA African Americans1.0
Indig. Australian Yuendumu0.8
PNG Wanigela0.8
Mexico Zaptotec Oaxaca0.7
Spain Eastern Andalusia0.6
South African Natal Zulu0.5
Spain E. Andalusia Gipsy0.5
Sudanese0.5
Taiwan Bunun0.5
HLA B*1515 frequencies
freq
ref.Population(%)
[3] Mexico Mestizos2.4
Mex. Guadalajara Mestizos (2)1.9
Argentina Toba Rosario1.2
China Guangdong Meizhou Han1.0
China North Han1.0
Cape Verde NW Islands0.8
USA South Texas Hispanics0.8
USA San Antonio Caucasians0.6
USA Hispanic0.4
USA Asian0.3
USA North American Natives0.3
USA African America0.2
Hong Kong Chinese0.1
HLA B*1525 frequencies
freq
ref.Population(%)
[3] Taiwan Tao40.0
Taiwan Thao11.7
Taiwan Pazeh10.9
China Yunnan Lisu8.7
China Yunnan Nu8.3
PNG West Schrader Ranges8.2
Indig. Australian Groote Eylandt8.0
Taiwan Puyuma7.0
Taiwan Rukai7.0
Taiwan Bunun6.4
Indig. Australian Yuendumu5.7
Taiwan Siraya4.9
Taiwan Tsou4.9
Philippines Ivatan3.0
Taiwan Atayal2.8
Taiwan Ami2.6
Thailand2.5
China Guangzhou2.0
Thailand pop32.0
Hong Kong Chinese1.9
PNG Wanigela1.5
PNG Wosera1.5
Singapore Thai1.5
India Andhra Pradesh Golla1.4
PNG Eastern Highlands Goroka1.4
China South Han1.1
China Inner Mongolia1.0
India North Hindus1.0
HLA B*1507 frequencies
freq
ref.Population(%)
[3] Argentina Toba Rosario8.1
New Mexico Canoncito Navajo3.7
Brazil Terena2.6
USA North American Natives0.8
Japan Central0.7
South Korea pop 30.6
Japan pop30.4
USA Asian0.4
Shijiazhuang Tianjian Han0.3
USA Caucasian pop20.2
Hong Kong Chinese0.1
Ireland Northern0.1

Related Research Articles

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HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

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HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif, indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence.

HLA-B46 (B46) is an HLA-B serotype. The serotype identifies the gene products of HLA-B*4601 allele. B*4601 resulted from a rare, interlocus, gene conversion between B62, probably B*1501, and a HLA-C allele. B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele. When found B*4601 segregates with only 2 HLA-Cw alleles, A limited number of HLA-A and HLA-DRB1 alleles suggesting that the allele recently expanded from a limited sized group within SE Asia. Extremely low frequencies outside of Eastern Asia are indicators of a recent expansion of B46 from a recently small population. The frequency distribution suggests the ancestral B46 population was in SE China, or, potentially Burma. B46 in Asia correlates with wet-rice farming. The exceptions are notable, it has been found in the Nivkhi on north-eastern Sakalin Island, the Ainu, and the Nivkhi-related (genetically) Tlinglet population of Alaska at trace levels.

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products. HLA-B*4201 is common in Central Africa.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

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HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

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<span class="mw-page-title-main">HLA-B70</span>

HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.

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References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ derived from IMGT/HLA
  3. 1 2 3 4 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
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