 | ||
| HLA-B (alpha)-β2MG with bound peptide | ||
major histocompatibility complex (human), class I, B63 | ||
| Alleles | *1516, *1517 | |
| Structure (See HLA-B) | ||
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. [1]
B63 is one of many split antigens of the broad antigen, B15. B63 identifies the B*1516 and B*1517 allele products.
| B*15 | B15 | B62 | B63 | B70 | B71 | B72 | B75 | B76 | B77 | Sample |
| allele | % | % | % | % | % | % | % | % | % | size (N) |
| *1516 | 3 | 80 | 816 | |||||||
| *1517 | 2 | 88 | 797 | |||||||
| Alleles link-out to IMGT/HLA Databease at EBI | ||||||||||
| freq | ||
| ref. | Population | (%) |
| [3] | Ivory Coast Akan Adiopodoume | 4.6 |
| Cameroon Bamileke | 3.2 | |
| USA African Americans (3) | 1.9 | |
| Italy South Campania | 1.6 | |
| United Arab Emerates | 1.5 | |
| Brazil | 1.4 | |
| Azores S. Maria and S. Miguel | 1.3 | |
| Zimbabwe Harare Shona | 1.3 | |
| Cameroon Beti | 1.1 | |
| Cameroon Yaounde | 1.1 | |
| Mali Bandiagara | 1.1 | |
| Tunisia Tunis | 1.1 | |
| Kenya Nandi | 1.0 | |
| Cape Verde SE Islands | 0.8 | |
| Kenya | 0.7 | |
| Uganda Kampala | 0.6 | |
| Brazil Belo Horizonte | 0.5 | |
| South African Natal Zulu | 0.5 | |
| Sudanese | 0.5 | |
| Tunisia | 0.5 | |
| Kenya Luo | 0.4 | |
| Oman | 0.4 |
| freq | ||
| ref. | Population | (%) |
| [3] | India Khandesh Pawra | 9.0 |
| South Africa Natal Tamil | 3.1 | |
| Saudi Arabia Guraiat and Hail | 2.7 | |
| Mexico Zaptotec Oaxaca | 2.2 | |
| India North Hindus | 1.9 | |
| Bulgaria | 1.8 | |
| India North Delhi | 1.6 | |
| China Inner Mongolia | 1.5 | |
| Georgia Tbilisi Georgians | 1.4 | |
| Kenya Luo | 1.3 | |
| Cuban Mulatto | 1.2 | |
| Brazil Belo Horizonte | 1.1 | |
| Cameroon Yaounde | 1.1 | |
| Portugal North | 1.1 | |
| Tunisia Tunis | 1.1 | |
| Kenya Nandi | 1.0 | |
| Portugal Centre | 1.0 | |
| China Qinghai Hui | 0.9 | |
| Israel Ashk. and Non Ashk.i Jews | 0.9 | |
| Azores Terceira Island | 0.8 | |
| Cape Verde Southeastern Islands | 0.8 | |
| France South East | 0.8 | |
| India New Delhi | 0.8 | |
| Russia Tuva pop 2 | 0.8 | |
| Sudanese | 0.8 | |
| USA African Americans pop3 | 0.8 | |
| USA Caucasian pop2 | 0.8 | |
| Brazil | 0.7 | |
| Cuban White | 0.7 | |
| Thailand | 0.7 | |
| USA Philadelphia Caucasians | 0.7 | |
| Cameroon Beti | 0.6 | |
| Romanian | 0.6 | |
| Czech Republic | 0.5 | |
| Singapore Thai | 0.5 | |
| Spain Eastern Andalusia Gipsy | 0.5 |
HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.
HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.
HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.
HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product. Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes. B73 is more common in Western Indian Ocean, Mediterranean and Africa.
HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.
HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.
HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products. HLA-B*4201 is common in Central Africa.
HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.
HLA-B37 (B37) is an HLA-B serotype. The serotype identifies the more common HLA-B*37 gene products.
HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.
HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.
HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.
HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.
HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.
HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.
HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.
HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.
HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.
HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.
HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.