HLA-B39

Last updated
HLA-B.png
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B39
AllelesB*3901, 3902, 3903, . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B39 (B39) is an HLA-B serotype. The serotype identifies the more common HLA-B*39 gene products. [1]

Contents

B39 is a split antigen of the broad antigen B16, and is a sister type of B38. B39 is most commonly found on the west pacific rim, in Japan and highest frequency in the new world. In Europe it is found in Scandinavia and Northern Russia.

Serotype

Serotypes B39, B16, and B38 recognition of the
HLA B*39 gene products [2]
B*39B39B16B38Sample
allele % % %size (N)
*3901 95476
*3902 8796
*3903 7720
*3905 82245
*3906 94508
*3908 4857
*3909 9713
*3910 82127
*3911 6916
Alleles link-out to IMGT/HLA Databease at EBI

The serology for the most common B39 alleles, B*3901 and B*3906 is good, but some allele products are not well detected. Given the differential involvement of these alleles in disease testing should involve high resolution typing.

HLA B*3906 frequencies
freq
ref.Population(%)
[3] Venezuela Perja Mountain Bari23.9
Mexico Mixtec Oaxaca8.8
USA Arizona Pima7.3
USA South Texas Hispanics5.6
Mexico Zaptotec Oaxaca4.5
New Mexico Canoncito Navajo3.7
Oman2.5
PNG Wanigela2.3
Tunisia Tunis2.3
North American Natives1.9
USA Hispanic1.7
Brazil Belo Horizonte1.6
South Dakota Lakota Sioux1.5
Cuban White1.4
Azores S. Maria & S. Miguel1.3
Australia New South Wales1.1
Finland1.1
Portugal North1.1
Portugal Centre1.0
Spain Eastern Andalusia Gipsy1.0
Brazil Terena0.9
Ireland Northern0.9
Azores Terceira Island0.8
USA Caucasian pop20.8
Brazil0.7
USA Philadelphia Caucasians0.7
India Andhra Pradesh Golla0.5
Thailand0.4

Alleles

HLA B*3901 frequencies
freq
ref.Population(%)
[3] Taiwan Saisiat54.9
[3] Taiwan Tsou24.5
[3] South Dakota Lakota Sioux22.5
[3] Taiwan Taroko21.8
[3] Taiwan Atayal19.8
[3] PNG Wanigela16.7
[3] Japan Ainu Hokkaido16.0
[3] Taiwan Bunun14.9
[3] New Mexico Canoncito Navajo14.6
[3] Taiwan Thao13.3
[3] Taiwan Rukai13.0
[3] Taiwan Ami10.2
[3] USA Hawaii Okinawa7.7
[3] Papua New Guinea Wosera7.0
[3] Papua New Guinea Madang6.4
[3] Mexico Mixtec Oaxaca5.9
[3] Taiwan Puyuma5.0
[3] Taiwan Paiwan4.9
[3] New Caledonia4.8
[3] Japan Central4.4
[3] American Samoa4.0
[3] USA North American Natives4.0
[3] Taiwan Hakka3.6
[3] Indig. Australian Cape York Peninsula3.5
[3] Japan (5)3.5
[3] Philippines Ivatan3.0
[3] Brazil2.9
[3] China Guangxi Maonan2.8
[3] Georgia Tbilisi Georgians2.8
[3] China Yunnan Nu2.6
[3] Thailand2.5
[3] Azores Terceira Island2.4
[3] Singapore Chinese2.4
[3] Romanian2.3
[3] China Yunnan Lisu2.2
[3] Indig. Australian Yuendumu2.1
[3] China Guangzhou2.0
[3] Croatia2.0
[3] France South East1.9
[3] Georgia Svaneti Svans1.9
[3] PNG Karimui Plateau1.9
[3] Azores Central Islands1.8
[3] Spain Eastern Andalusia1.8
[3] Uganda Kampala1.6
[3] Mexico Zaptotec Oaxaca1.5
[3] Singapore Thai1.5
[3] China Guangzhou Han1.4
[3] China Qinghai Hui1.4
[3] Czech Republic1.4
[3] Madeira1.4
[3] Indig. Australian Kimberly1.3
[3] Finland1.1

Disease

B39 is suggested as a factor in Takayasu's arteritis and gallstones in Mexico. [4] Osteoarticular complications of brucellosis appear to be associated with B39. [5] An association with spondylarthropathies [6] [7] and psoriatic arthritis [8] [9] was observed in several studies. Psoriatic arthritis appears to be linked to MICA-A9 which tightly linked to HLA-B39. [10] [11] B39 also appears to be involved in the Fishers syndrome variant of Guillain–Barré syndrome. [12]

B39 appears to be protective against cardiomyopathy in Chaga's disease indicating a possible selective factor in its rise in the New World. [13] Chaga's disease is caused by a trypanosome carried by a blood sucking insect found in tropical, palm growing regions.

Southern California now reports cases of Chaga's disease from contaminated transfusions and may be already a habitat for the vector. [14]

In Takayasu's arteritis

Takayasu's arteritis appears to have a link to B39. [15] [16] The association with B*3902 increases risk of pulmonary infarction, ischemic heart disease, aortic regurgitation, systemic hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance. [17] B*3906, common in indigenous Mesoamericans has been found associated with the same disease. [18]

HLA B*3902 frequencies
freq
ref.Population(%)
[3] Mexico Mixe Oaxaca38.7
Mexico Zaptotec Oaxaca13.4
Mexico Mixtec Oaxaca5.9
Mexico Mestizos1.2
Japan pop50.9
Cuban White0.7
Israel Ashk. and Non Ashk. Jews0.5
Japan Central0.5
Senegal Niokholo Mandenka0.5
B*3903
PNG New Britain Rabaul13.2
Brazil Terena11.2
Argentina Toba Rosario5.2
Brazil0.7
Finland0.6
Kenya Luo0.6
North American Natives0.5
B*3904
Argentina Toba Rosario1.2
Georgia Svaneti Svans0.6
Jordan Amman0.3
Shijiazhuang Tianjian Han0.1
Japan Central0.1
Romanian0.1
B*3905
Venezuela Perija Yucpa36.1
Mexico Zaptotec Oaxaca12.7
Mexico Mixtec Oaxaca9.8
Mexico Mestizos4.9
Arizona Pima4.5
Mexico Guadalajara Mestizos2.4
Argentina Toba Rosario2.3
USA Hispanic2.1
Mexico Mixe Oaxaca1.9
Cuban White1.4
Mexico Chihuahua Tarahumara1.1
USA North American Natives0.5
Shijiazhuang Tianjian Han0.2
B*3907
Shijiazhuang Tianjian Han0.6
Singapore Thai0.5
China South Han0.2
B*3908
Mexico Zaptotec Oaxaca2.2
Mexico Mestizos1.2
Mexico Mixtec Oaxaca1.0
Brazil0.7
USA Hispanic0.6
B*3909
Venezuela Perija Yucpa34.9
Thailand pop33.1
Brazil Terena1.7
China South Han1.4
Argentina Toba Rosario1.2
China Qinghai Hui0.9
B*3910
Sudanese2.5
Senegal Niokholo Mandenka2.1
South African Natal Zulu1.5
Cameroon Beti1.4
Spain Eastern Andalusia1.2
Kenya Luo1.1
Israel Arab Druse1.0
Kenya Nandi1.0
Guinea Bissau0.8
Kenya0.7
Mali Bandiagara0.7
Morocco Nador Metalsa Class I0.7
Cameroon Bamileke0.6
Cameroon Yaounde0.5
Israel Ashk. and Non Ashk. Jews0.5
Saudi Arabia Guraiat and Hail0.5

Related Research Articles

<span class="mw-page-title-main">Takayasu's arteritis</span> Medical condition

Takayasu's arteritis (TA), also known as aortic arch syndrome, nonspecific aortoarteritis, and pulseless disease, is a form of large vessel granulomatous vasculitis with massive intimal fibrosis and vascular narrowing, most commonly affecting young or middle-aged women of Asian descent, though anyone can be affected. It mainly affects the aorta and its branches, as well as the pulmonary arteries. Females are about 8–9 times more likely to be affected than males.

<span class="mw-page-title-main">HLA-DQ8</span>

HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β8 and this generally detects the gene product of DQB1*0302.

<span class="mw-page-title-main">HLA-DQ4</span>

HLA-DQ4 (DQ4) is a serotype subgroup within HLA-DQ(DQ) serotypes. The serotype is determined by the antibody recognition of β4 subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ4 are encoded by the HLA-DQB1*04 allele group. This group currently contains 2 common alleles, DQB1*0401 and DQB1*0402. HLA-DQ4 and HLA-DQB1*04 are almost synonymous in meaning. DQ4 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1 alleles, to form the cis-haplotype isoforms. These isoforms, nicknamed DQ4.3 and DQ4.4, are also encoded by the DQA1*0303 and DQA1*0401 genes, respectively.

<span class="mw-page-title-main">HLA-DQ1</span> Serotype that covers a broad range of HLA-DQ haplotypes.

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1; later, it was among 3 types DQw1, DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in individuals who bear the DQA1*01 alleles. The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket.

<span class="mw-page-title-main">HLA-DR16</span>

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

<span class="mw-page-title-main">HLA-DR11</span>

HLA-DR11 (DR11) is a HLA-DR serotype that recognizes the DRB1*1101 to *1110. DR11 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR12 antigens.

<span class="mw-page-title-main">HLA-DR12</span>

HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.

<span class="mw-page-title-main">HLA-DR5</span>

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

<span class="mw-page-title-main">HLA-DR4</span>

HLA-DR4 (DR4) is an HLA-DR serotype that recognizes the DRB1*04 gene products. The DR4 serogroup is large and has a number of moderate frequency alleles spread over large regions of the world.

<span class="mw-page-title-main">HLA-B81</span>

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif, indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence.

HLA-B47 (B47) is an HLA–B serotype. The serotype identifies the HLA-B*47 gene products. Comparison of B47 nucleotide sequence with other HLA-B sequences shows a segment of 228 bp identical with B44 in the alpha 1 domain and a segment of 218 bp identical with B27 in the alpha 2 domain, but only a 91 bp segment of identity with B13 in the alpha 1 domain. The complex pattern of substitutions and their degree of divergence indicate that HLA-B13 and HLA-Bw47 alleles are not related by a simple mutational event. B47 is linked to a gene that causes adrenal deficiency. B47 is generally low in frequency and with highest known frequencies in Central and Western Africa.

<span class="mw-page-title-main">TAP2</span> Protein-coding gene in the species Homo sapiens

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.

<span class="mw-page-title-main">HLA-B7</span>

HLA-B7 (B7) is an HLA-B serotype. The serotype identifies the more common HLA-B*07 gene products. B7, previously HL-A7, was one of the first 'HL-A' antigens recognized, largely because of the frequency of B*0702 in Northern and Western Europe and the United States. B7 is found in two major haplotypes in Europe, where it reaches peak frequency in Ireland. One haplotype A3-B7-DR15-DQ1 can be found over a vast region and is in apparent selective disequilibrium. B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies.

<span class="mw-page-title-main">HLA-B51</span> Serotype

HLA-B51 (B51) is an HLA-B serotype. The serotype identifies the more common HLA-B*51 gene products.

<span class="mw-page-title-main">HLA-B52</span>

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.

<span class="mw-page-title-main">HLA-B38</span>

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

<span class="mw-page-title-main">HLA-B44</span>

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.

HLA A30-Cw5-B18-DR3-DQ2 (A30::DQ2) is a multigene haplotype that extends across a majority of the major histocompatibility complex on human chromosome 6. A multigene haplotype is a set of inherited alleles covering several genes, or gene-alleles. Long haplotypes, like A30::DQ2, are generally the result of descent by common ancestry. As haplotypes increase in size, Chromosomal recombination fragments them in a generation dependent process.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ derived from IMGT/HLA
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
  4. ↑ Méndez-Sánchez N, King-Martínez AC, Ramos MH, Pichardo-Bahena R, Uribe M (November 2004). "The Amerindian's genes in the Mexican population are associated with development of gallstone disease". Am. J. Gastroenterol. 99 (11): 2166–70. PMID   15554998.
  5. ↑ Bravo MJ, Colmenero Jde D, Alonso A, Caballero A (May 2003). "HLA-B*39 allele confers susceptibility to osteoarticular complications in human brucellosis". J. Rheumatol. 30 (5): 1051–3. PMID   12734905.
  6. ↑ Sobao Y, Tsuchiya N, Takiguchi M, Tokunaga K (January 1999). "Overlapping peptide-binding specificities of HLA-B27 and B39: evidence for a role of peptide supermotif in the pathogenesis of spondylarthropathies". Arthritis Rheum. 42 (1): 175–81. doi: 10.1002/1529-0131(199901)42:1<175::AID-ANR21>3.0.CO;2-7 . PMID   9920028.
  7. ↑ Alvarez I, López de Castro JA (July 2000). "HLA-B27 and immunogenetics of spondyloarthropathies". Curr Opin Rheumatol. 12 (4): 248–53. doi:10.1097/00002281-200007000-00003. PMID   10910175.
  8. ↑ Eastmond CJ (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology. 8 (2): 263–76. doi:10.1016/S0950-3579(94)80018-9. PMID   8076387.
  9. ↑ Gladman DD, Farewell VT (June 1995). "The role of HLA antigens as indicators of disease progression in psoriatic arthritis. Multivariate relative risk model". Arthritis Rheum. 38 (6): 845–50. doi: 10.1002/art.1780380619 . PMID   7779129.
  10. ↑ Bolognesi E, Dalfonso S, Rolando V, Fasano ME, Praticò L, Momigliano-Richiardi P (October 2001). "MICA and MICB microsatellite alleles in HLA extended haplotypes". Eur. J. Immunogenet. 28 (5): 523–30. doi:10.1046/j.0960-7420.2001.00250.x. PMID   11881819.
  11. ↑ González S, Martínez-Borra J, López-Vázquez A, García-Fernández S, Torre-Alonso JC, López-Larrea C (May 2002). "MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis". J. Rheumatol. 29 (5): 973–8. PMID   12022360. Archived from the original on 2008-12-04. Retrieved 2008-08-03.
  12. ↑ Yuki N, Sato S, Tsuji S, Ogawa K, Miyatake T (June 1993). "Human leukocyte antigens in Fisher's syndrome". Ann. Neurol. 33 (6): 655–7. doi:10.1002/ana.410330617. PMID   8498847.
  13. ↑ Cruz-Robles D, Reyes PA, Monteón-Padilla VM, Ortiz-Muñiz AR, Vargas-Alarcón G (January 2004). "MHC class I and class II genes in Mexican patients with Chagas disease". Hum. Immunol. 65 (1): 60–5. doi:10.1016/j.humimm.2003.10.008. PMID   14700597.
  14. ↑ "Chagas Disease Represents New Challenge for Blood Supply Safety".
  15. ↑ Kimura A, Kitamura H, Date Y, Numano F (August 1996). "Comprehensive analysis of HLA genes in Takayasu arteritis in Japan". Int. J. Cardiol. 54 Suppl: S61–9. doi:10.1016/s0167-5273(96)88774-2. PMID   9119528.
  16. ↑ Yoshida M, Kimura A, Katsuragi K, Numano F, Sasazuki T (August 1993). "DNA typing of HLA-B gene in Takayasu's arteritis". Tissue Antigens. 42 (2): 87–90. doi:10.1111/j.1399-0039.1993.tb02242.x. PMID   7903491.
  17. ↑ Kitamura H, Kobayashi Y, Kimura A, Numano F (October 1998). "Association of clinical manifestations with HLA-B alleles in Takayasu arteritis". Int. J. Cardiol. 66 Suppl 1: S121–6. doi:10.1016/S0167-5273(98)00159-4. PMID   9951811.
  18. ↑ Rodríguez-Reyna TS, Zúñiga-Ramos J, Salgado N, et al. (October 1998). "Intron 2 and exon 3 sequences may be involved in the susceptibility to develop Takayasu arteritis". Int. J. Cardiol. 66 Suppl 1: S135–8, discussion S139. doi:10.1016/S0167-5273(98)00161-2. PMID   9951813.
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