HLA-B14

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HLA-B.png
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B14
AllelesB*1401, 1402 . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B14 (B14) is a HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B. [1]

Contents

B14 is a broad antigen composed to two, B64 and B65, split antigens. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below).

Serotype

B14, B64, B65 serotype recognition of some
HLA B*14 allele-group gene products [2]
B*14B14B64B65Sample
allele % % %size (N)
*14017210101006
*1402712252244
*1403503540
Alleles link-out to IMGT/HLA Databease at EBI

HLA-B64

This serotype does not have good recognition of any of the alleles, relatively speaking recognizes B*1401 better.

HLA-B65

This serotype recognizes B*1402 and B*1403 but less so than B14 and to a minor degree it recognized B*1401.

Related Research Articles

<span class="mw-page-title-main">Human leukocyte antigen</span> Genes on human chromosome 6

The human leukocyte antigen (HLA) system or complex of genes on chromosome 6 in humans which encode cell-surface proteins responsible for regulation of the immune system. The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals.

<span class="mw-page-title-main">HLA-B5</span>

HLA-B5 (B5) is an HLA-B serotype. B5 is a broad antigen serotype that recognizes the B51 and B52 split antigen serotypes.

<span class="mw-page-title-main">HLA-B81</span> Human leukocyte antigen serotype

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

<span class="mw-page-title-main">HLA-B16</span> Human leukocyte antigen serotype

HLA-B16 (B16) is an HLA - B serotype. B16 is a broad antigen serotype that recognizes the B38 and B39 split antigen serotypes.

HLA-B21 (B21) is an HLA - B serotype. B21 is a broad antigen serotype that recognizes the B49 and B50 split antigen serotypes.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B58</span> Human leukocyte antigen serotype

HLA-B58 (B58) is an HLA-B serotype. B58 is a split antigen from the B17 broad antigen, the sister serotype B57. The serotype identifies the more common HLA-B*58 gene products. B*5801 is associated with allopurinol induced inflammatory necrotic skin disease.

<span class="mw-page-title-main">HLA-B52</span> Human leukocyte antigen serotype

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.

<span class="mw-page-title-main">HLA-B38</span> Human leukocyte antigen serotype

HLA-B38 (B38) is an HLA-B serotype. The serotype identifies the B*38 allele products of the HLA-B gene-locus.

<span class="mw-page-title-main">HLA-B44</span> Human leukocyte antigen serotype

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B45</span> Human leukocyte antigen serotype

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B77</span> Human leukocyte antigen serotype

HLA-B77 (B77) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B75</span> Human leukocyte antigen serotype

HLA-B75 (B75) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B70</span> Human leukocyte antigen serotype

HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. B70 is one of many split antigens of the broad antigen, B15.

<span class="mw-page-title-main">HLA-B63</span> Human leukocyte antigen serotype

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B62</span> Human leukocyte antigen serotype

HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ Robinson J, Waller MJ, Fail SC, Marsh SG (2006). "The IMGT/HLA and IPD databases". Hum. Mutat. 27 (12): 1192–9. doi: 10.1002/humu.20406 . PMID   16944494.
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