HLA-B70

Last updated
HLA-B.png
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B70
Alleles*1503, *1509, *1510,
*1518, *1529, *1537
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

HLA-B70 (B70) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B. [1] B70 is one of many split antigens of the broad antigen, B15.

Contents

Serotype

Serotypes B15, B62, B63, B70, B71, B72, B75, B76, B77 recognition of the
HLA B*15 gene products [2]
B*15B15B62B63B70B71B72B75B76B77Sample
allele % % % % % % % % %size (N)
*1503 161102569
*1509 5365
*1510 1492211204
*1518 513552
*1529 1921
*1537 3034
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

HLA B*1503 frequencies
freq
ref.Population(%)
[3] Burkina Faso Rimaibe13.8
Guinea Bissau10.8
Cameroon Pygmy Baka10.0
South African Natal Zulu9.5
Kenya Luo8.9
Ivory Coast Akan Adiopodoume8.0
Kenya Nandi7.9
Cameroon Sawa7.7
Zimbabwe Harare Shona7.7
USA African America7.3
Burkina Faso Fulani7.1
Mali Bandiagara6.9
Senegal Niokholo Mandenka6.9
Cape Verde SE Islands6.5
Kenya6.3
Uganda Kampala6.2
Sudanese6.0
Zambia Lusaka5.7
Cameroon Yaounde4.9
Cape Verde NW Islands4.8
Oman4.7
Cameroon Bamileke4.5
Tunisia Tunis4.5
Cameroon Beti3.7
Brazil Belo Horizonte3.2
Azores Terceira Island2.4
Madeira2.2
Saudi Arabia Guraiat and Hail2.0
Tunisia2.0
United Arab Emerates1.5
Brazil1.4
Cuban White1.4
Morocco Nador Metalsa1.4
Mexico Mestizos1.2
Italy Bergamo1.1
Portugal North1.1
American Samoa1.0
Iran Baloch1.0
Mexico Guadalajara Mestizos (2)1.0
Azores Central Islands0.9
Israel Ashk. and Non-Ashk. Jews0.9
Taiwan Hakka0.9
Croatia0.7
HLA B*1509 frequencies
freq
ref.Population(%)
[3] Burkina Faso Fulani4.1
India West Coast Parsis3.0
Spain Eastern Andalusia Gipsy3.0
Mexico Mestizos2.4
Italy South Campania1.2
Burkina Faso Rimaibe1.1
China Inner Mongolia1.0
Mali Bandiagara0.7
Czech Republic0.5
HLA B*1510 frequencies
freq
ref.Population(%)
[3] South African Natal Zulu8.5
Zimbabwe Harare Shona8.4
Ivory Coast Akan Adiopodoume5.7
Kenya5.2
Zambia Lusaka4.6
Cameroon Sawa3.8
Guinea Bissau3.8
Kenya Luo3.6
Senegal Niokholo Mandenka3.2
Cameroon Beti2.8
USA African Americans (3)2.7
Uganda Kampala2.5
Mexico Mestizos2.4
Mali Bandiagara2.2
Kenya Nandi1.7
Brazil Belo Horizonte1.6
Cameroon Bamileke1.3
Cuban Mulatto1.2
Cameroon Yaounde1.1
Iran Baloch1.0
Sudanese1.0
Tunisia1.0
Brazil Terena0.9
Cape Verde NW Islands0.8
United Arab Emerates0.8
USA North American Natives0.8
Guadalajara Mestizos (2)0.5
HLA B*1518 frequencies
freq
ref.Population(%)
[3] South Africa Natal Tamil4.1
Autonomous Tibetans3.8
India Mumbai Marathas3.7
China North Han2.9
USA Hawaii Okinawa2.9
China Guangzhou Han2.4
India Andhra Pradesh Golla2.4
China Beijing2.3
Taiwan Hakka1.8
Japan1.7
India North Delhi1.6
China Inner Mongolia1.5
China Qinghai Hui1.4
Czech Republic1.4
China Yunnan Nu1.3
Shijiazhuang Tianjian Han1.1
Ivory Coast Akan Adiopodoume1.1
Senegal Niokholo Mandenka1.1
Zambia Lusaka1.1
Portugal Centre1.0
Singapore Javanese Indonesians1.0
Thailand (3)1.0
South Korea (3)0.9
Cape Verde Islands0.8
France South East0.8
Guinea Bissau0.8
China South Han0.7
China Yunnan Lisu0.7
Russia Tuva (2)0.6
Singapore Chinese Han0.6
Spain Eastern Andalusia0.6

Related Research Articles

<span class="mw-page-title-main">HLA-B*82</span>

HLA-B*82 (B*82) is an HLA-B allele-group. There is no current useful serotyping for HLA-B*82 gene products. B*8201 was first identified by sequence analysis and appears to be derived by gene conversion between B*5602 and another HLA class I allele., later B*8202 was identified in a caucasian and was suggested to be ancestral to B*8201, as product between gene conversion of B*5602 allele and B*4501 allele. B*82 is more common in East Africa, Kenya and Sudan, the frequency of B*8201 is found in the peoples to the west, sporadically in Central and West Africa, B*8202 is found in Sudan and Saudi Arabia.

<span class="mw-page-title-main">HLA-B81</span>

HLA-B81 (B81) is an HLA–B serotype. The serotype identifies the HLA-B*8101 and B*8102 gene products. B81 is more common in Subsaharan Africa. While there is a B81 serotype, serotyping of B81 is poor when simultaneously tested with anti-B7 or B48 antibodies.

HLA-B78 (B78) is an HLA-B serotype. The serotype identifies the more common HLA-B*78 gene products. B78 is more common in West and North Africa, but is also scattered at low frequencies in parts of Asia.

HLA-B73 (B73) is an HLA-B serotype. The serotype identifies the HLA-B*7301 gene product. Part of B*7301 is similar to the HLA-B22 family, however part resembles the domains seen in other apes. B73 is more common in Western Indian Ocean, Mediterranean and Africa.

HLA-B67 (B67) is an HLA-B serotype. The serotype identifies the more common HLA-B*67 gene products. B67 is region specific recombinant haplotype formed by the gene conversion of B*39, an allele common along the Northwest Pacific Rim, and B7, B22, or B27.

HLA-B59 (B59) is an HLA-B serotype. The serotype identifies the more common HLA-B*## gene products. B59 is a hybrid between B*55 and B*51. B59 is more common in Japan, Korea, N. China and Mongolia.

HLA-B53 (B53) is an HLA-B serotype. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35 but short sequence specifies a Bw4 rather than a Bw6 motif, indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence.

HLA-B42 (B42) is an HLA-B serotype. The serotype identifies the HLA-B*4201 and *4202 gene products. HLA-B*4201 is common in Central Africa.

HLA-B41 (B41) is an HLA-B serotype. The serotype identifies HLA-B*4101, *4102, *4103 gene products.

HLA-B18 (B18) is an HLA-B serotype. The serotype identifies the more common HLA-B*18 gene products. B*1801, the most common allele is at highest frequencies in Northern Italy and the Balkans, a peak frequency distribution it shares with B*3501.

HLA-B13 (B13) is an HLA-B serotype. The serotype identifies the more common HLA-B*13 gene products.

<span class="mw-page-title-main">HLA-B8</span>

HLA-B8 (B8) is an HLA-B serotype. The serotype identifies the HLA-B*08 gene products. HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease.

HLA-B56 (B56) is an HLA-B serotype. B56 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B55. The serotype identifies the more common HLA-B*56 gene products.

HLA-B55 (B55) is an HLA-B serotype. B55 is a split antigen from the B22 broad antigen, sister serotypes are B54 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B54 (B54) is an HLA-B serotype. B54 is a split antigen from the B22 broad antigen, sister serotypes are B55 and B56. The serotype identifies the more common HLA-B*55 gene products.

HLA-B50 (B50) is an HLA-B serotype. B50 is a split antigen from the B21 broad antigen, the sister serotype B49. The serotype identifies the more common HLA-B*50 gene products.

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products.

<span class="mw-page-title-main">HLA-B52</span>

HLA-B52 (B52) is an HLA-B serotype. The serotype identifies the more common HLA-B*52 gene products.

<span class="mw-page-title-main">HLA-B63</span>

HLA-B63 (B63) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

<span class="mw-page-title-main">HLA-B62</span>

HLA-B62 (B62) is an HLA-B serotype. The serotype identifies certain B*15 gene-allele protein products of HLA-B.

References

  1. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC   2848993 . PMID   20356336.
  2. ↑ derived from IMGT/HLA
  3. 1 2 3 4 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi: 10.1034/j.1399-0039.2003.00062.x . PMID   12753660.
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