Histomonas meleagridis

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Histomonas meleagridis
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Phylum: Metamonada
Order: Tritrichomonadida
Family: Dientamoebidae
Genus: Histomonas
Tyzzer, 1920 [1]
Species:
H. meleagridis
Binomial name
Histomonas meleagridis
(Smith, 1895)

Histomonas meleagridis is a species of parasitic protozoan that infects a wide range of birds including chickens, turkeys, peafowl, quail and pheasants, causing infectious enterohepatitis, or histomoniasis (blackhead diseases). H. meleagridis can infect many birds, but it is most deadly in turkeys. It inhabits the lumen of cecum and parenchyma of liver, where it causes extensive necrosis. It is transmitted by another cecal parasite, the nematode Heterakis gallinarum .

Contents

Description

Histomonas meleagridis is a microscopic, pleomorphic protozoan, and can exist in two forms, amoeboid and flagellated. Within the tissue, it is present as an amoeboid protozoan, while in the lumen or free in the contents of cecum, it lives as an elongated flagellated form. The amoeboid form is typically 8–15 μm in diameter, whereas the flagellated form can reach up to 30 μm in diameter. [2] Histomonads do not possess mitochondria, but instead produce energy inside hydrogenosomes. [3] The flagellum shows the common 9x2+2 type. [3]

Lifecycle

Histomonas meleagridis reproduces by binary fission. The free trophozoites are very delicate and can survive only for a few hours in the external environment. However, when they are transmitted between flocks in the eggs of Heterakis gallinarum , a cecal nematode, which in turn can be transmitted by earthworms that ingested the nematode eggs, they gain entry into the nematode eggs. The eggs with the trophozoites are passed out into the environment through the feces. In this way, the trophozoites can remain viable up to two years in the external environment. [2] Within turkey flocks H. meleagridis is also known to be directly transmitted from bird to bird. Histomonads, either released from the heterakid nematode larvae in the ceca or after direct infection via the cloaca, replicate rapidly in the cecal tissues. [4] They migrate to the submucosa and muscularis mucosae and cause severe necrosis. The parasites then move to the liver through the vascular system. There, they cause typical crater-like necrotic lesions. [5] Mortality in turkey flocks can be very high (80-100%). [6]

Pathogenicity

Histomonas meleagridis is the causal organism of histomoniasis of gallinaceous birds. It induces extensive and severe necrosis of the tissues of the mucosa and submucosa of cecum and parenchyma of the liver. The lesions are sometimes exacerbated by other pathogens such as Escherichia coli and coccidia. [7] The symptoms appear within seven to 12 days after infection, and include depression, reduced appetite, poor growth, increased thirst, sulphur-yellow diarrhoea, listlessness, drooping wings, and unkempt feathers. [5] The symptoms are highly fatal to turkeys, but effect less damage in chickens. However, outbreaks in chickens may result in high morbidity, moderate mortality, and extensive culling, leading to overall poor flock performance. [6] Concurrence of Salmonella typhmurium and E. coli was found to cause high mortality in broiler chickens. [7] Young birds, particularly those three to 12 weeks old, are most susceptible. Generally, the symptoms are profound in turkeys, while chickens are usually asymptomatic. [2]

Diagnosis and control

Diagnosis can be easily performed by necropsy of the fresh or preserved carcass, particularly on the liver. Recently paromomycin has been approved by the Italian authorities for treatment (Paromomicina 200 mg/g Huvepharma). However good management of the farm and sanitation are the essential effective strategies to control the spread of infection. [8] [9]

Related Research Articles

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<i>Heterakis gallinarum</i> Species of roundworm

Heterakis gallinarum is a nematode parasite that lives in the cecum of some galliform birds, particularly in ground feeders such as domestic chickens and turkeys. It causes infection that is mildly pathogenic. However, it often carries a protozoan parasite Histomonas meleagridis which causes of histomoniasis. Transmission of H. meleagridis is through the H. gallinarum egg. H. gallinarum is about 1–2 cm in length with a sharply pointed tail and a preanal sucker. The parasite is a diecious species with marked sexual dimorphism. Males are smaller and shorter, measuring around 9 mm in length, with a unique bent tail. Females are stouter and longer, measuring roughly 13 mm in length, with a straight tail end.

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<span class="mw-page-title-main">Histomoniasis</span> Medical condition

Histomoniasis is a commercially significant disease of poultry, particularly of chickens and turkeys, due to parasitic infection of a protozoan, Histomonas meleagridis. The protozoan is transmitted to the bird by the nematode parasite Heterakis gallinarum. H. meleagridis resides within the eggs of H. gallinarum, so birds ingest the parasites along with contaminated soil or food. Earthworms can also act as a paratenic host.

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<i>Chilomastix</i> Genus of flagellates

Chilomastix is a genus of pyriform excavates within the family Retortamonadidae All species within this genus are flagellated, structured with three flagella pointing anteriorly and a fourth contained within the feeding groove. Chilomastix also lacks Golgi apparatus and mitochondria but does possess a single nucleus. The genus parasitizes a wide range of vertebrate hosts, but is known to be typically non-pathogenic, and is therefore classified as harmless. The life cycle of Chilomastix lacks an intermediate host or vector. Chilomastix has a resistant cyst stage responsible for transmission and a trophozoite stage, which is recognized as the feeding stage. Chilomastix mesnili is one of the more studied species in this genus due to the fact it is a human parasite. Therefore, much of the information on this genus is based on what is known about this one species.

References

  1. Tyzzer, Ernest Edward (1920). "The Flagellate Character and Reclassification of the Parasite Producing "Blackhead" in Turkeys: Histomonas (Gen. nov.) meleagridis (Smith)". The Journal of Parasitology. 6 (3): 124–131. doi:10.2307/3271065. JSTOR   3271065 . Retrieved 30 July 2024 via JSTOR.
  2. 1 2 3 Griffiths HJ (1978). A Handbook of Veterinary Parasitology: Domestic Animals of North America. University of Minnesota Press, Minneapolis, Minnesota, USA, pp. 23–25. ISBN   0-8166-0828-8
  3. 1 2 Mielewczik, Michael; Mehlhorn, Heinz; Al-Quraishy, Saleh; Grabensteiner, E.; Hess, M. (1 September 2008). "Transmission electron microscopic studies of stages of Histomonas meleagridis from clonal cultures". Parasitology Research. 103 (4): 745–50. doi:10.1007/s00436-008-1009-1. ISSN   0932-0113. PMID   18626664. S2CID   2331300.
  4. Hu J, McDougald LR (2003). "Direct lateral transmission of Histomonas meleagridis in turkeys". Avian Diseases. 47 (2): 489–492. doi:10.1637/0005-2086(2003)047[0489:DLTOHM]2.0.CO;2. PMID   12887212. S2CID   22568033.
  5. 1 2 McDougald LR (2005). "Blackhead disease (histomoniasis) in poultry: a critical review". Avian Diseases. 49 (4): 462–476. doi:10.1637/7420-081005R.1. PMID   16404985. S2CID   43031620.
  6. 1 2 McDougald LR (1998). "Intestinal protozoa important to poultry". Poultry Science. 77 (8): 1156–1158. doi: 10.1093/ps/77.8.1156 . PMID   9706082.[ permanent dead link ]
  7. 1 2 Ganapathy K, Salamat MH, Lee CC, Johara MY (2000). "Concurrent occurrence of salmonellosis, colibaccillosis and histomoniasis in a broiler flock fed with antibiotic-free commercial feed". Avian Pathology. 29 (6): 639–642. doi: 10.1080/03079450020016000 . PMID   19184862. S2CID   25256520.
  8. Ballweber LR (2001). Veterinary parasitology: The Practical Veterinarian. Butterworth–Heinemann, Woburn, MA, USA, pp. 279–280. ISBN   0-7506-7261-7
  9. Callait-Cardinal MP, Gilot-Fromont E, Chossat L, Gonthier A, Chauve C, Zenne L (2010). "Flock management and histomoniasis in free-range turkeys in France: description and search for potential risk factors". Epidemiology and Infection. 138 (3): 353–363. doi: 10.1017/S0950268809990562 . PMID   19664306. S2CID   11535496.

Further reading

Hauck, Ruediger; Hafez, Hafez M. (2012). "Pigeons are Not Susceptible to Intracloacal Infection with Histomonas meleagridis" (PDF). Pakistan Veterinary Journal. 32 (4): 597–600. Retrieved 24 July 2016.

Billic, Ivana; Jaskulska, Barbara; Souillard, Rozenn; Liebhart, Dieter; Hess, Michael (21 March 2014). "Multi-Locus Typing of Histomonas meleagridis Isolates Demonstrates the Existence of Two Different Genotypes". PLOS ONE. 9 (3): e92438. Bibcode:2014PLoSO...992438B. doi: 10.1371/journal.pone.0092438 . PMC   3962415 . PMID   24658534.

Hauck, Ruediger; Hafez, Hafez M. (January 2013). "Experimental infections with the protozoan parasite Histomonas meleagridis: a review". Parasitology Research. 1 (112): 19–34. doi:10.1007/s00436-012-3190-5. PMID   23160894. S2CID   14662327.