Homospermidine synthase

Homospermidine synthase
Identifiers
EC no.	2.5.1.44
CAS no.	76106-84-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Homospermidine synthase (EC 2.5.1.44) is an enzyme with systematic name putrescine:putrescine 4-aminobutyltransferase (ammonia-forming). ^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

(1) 2 putrescine ${\displaystyle \rightleftharpoons }$ sym-homospermidine + NH₃ + H⁺

(2) putrescine + spermidine ${\displaystyle \rightleftharpoons }$ sym-homospermidine + propane-1,3-diamine

The reaction of this enzyme occurs in three steps.

See also

DHPS

References

1. Tait GH (February 1979). "The formation of homospermidine by an enzyme from Rhodopseudomonas viridis [proceedings]". Biochemical Society Transactions. 7 (1): 199–201. doi:10.1042/bst0070199. PMID   437275.
2. Böttcher F, Ober D, Hartmann T (1994). "Biosynthesis of pyrrolizidine alkaloids: putrescine and spermidine are essential substrates of enzymatic homospermidine formation". Can. J. Chem. 72 (1): 80–85. Bibcode:1994CaJCh..72...80B. doi: 10.1139/v94-013 .
3. Yamamoto S, Nagata S, Kusaba K (July 1993). "Purification and characterization of homospermidine synthase in Acinetobacter tartarogenes ATCC 31105". Journal of Biochemistry. 114 (1): 45–9. doi:10.1093/oxfordjournals.jbchem.a124137. PMID   8407874.
4. Srivenugopal KS, Adiga PR (August 1980). "Enzymic synthesis of sym-homospermidine in Lathyrus sativus (grass pea) seedlings". The Biochemical Journal. 190 (2): 461–4. doi:10.1042/bj1900461. PMC   1162113 . PMID   7470060.
5. Ober D, Tholl D, Martin W, Hartmann T (1996). "Homospermidine synthase of Rhodopseudomonas viridis: Substrate specificity and effects of the heterologously expressed enzyme on polyamine metabolism of Escherichia coli". J. Gen. Appl. Microbiol. 42 (5): 411–419. doi: 10.2323/jgam.42.411 .
6. Ober D, Hartmann T (December 1999). "Homospermidine synthase, the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, evolved from deoxyhypusine synthase". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14777–82. Bibcode:1999PNAS...9614777O. doi: 10.1073/pnas.96.26.14777 . PMC   24724 . PMID   10611289.

External links

• Homospermidine+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)