| Icosanoyl-CoA synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.119 | ||||||||
| CAS no. | 141256-55-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
In enzymology, an icosanoyl-CoA synthase (EC 2.3.1.119) is an enzyme that catalyzes the chemical reaction
- stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H+ icosanoyl-CoA + CO2 + CoA + 2 NAD(P)+ + H2O
The 5 substrates of this enzyme are stearoyl-CoA, malonyl-CoA, NADH, NADPH, and H+, whereas its 6 products are icosanoyl-CoA, CO2, CoA, NAD+, NADP+, and H2O.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing). Other names in common use include acyl-CoA elongase, C18-CoA elongase, and stearoyl-CoA elongase.
