List of adaptins

Clathrin adaptor proteins, also known as adaptins, are proteins that mediate the formation of vesicles for intracellular trafficking and secretion. Adaptins are clustered subunits of adaptor protein (AP) complexes. ^[1] There are several types of adaptin, each related to a different AP complex.

Adaptins show sequence similarity to some COPI subunits, thus they are thought to have a common evolutionary origin. ^[1] The adaptin is a heterotetramer consisting of two large adaptins (beta and one other depending on the complex), a medium adaptin (mu), and a small adaptin (sigma):

• complex 1
  • AP1B1
  • AP1G1
  • AP1G2
  • AP1M1
  • AP1M2
  • AP1S1
  • AP1S2
  • AP1S3
• complex 2
  • AP2A1
  • AP2A2
  • AP2B1
  • AP2M1
  • AP2S1
• complex 3
  • AP3B1
  • AP3B2
  • AP3D1
  • AP3M1
  • AP3M2
  • AP3S1
  • AP3S2
• complex 4
  • AP4B1
  • AP4E1
  • AP4M1
  • AP4S1
• complex 5 ^[2]
  • AP5Z1
  • AP5B1
  • AP5M1
  • AP5S1

A diagram of the 5 complexes is shown here

References

1. Boehm, Markus; Bonifacino, Juan S. (October 2001). "Adaptins". Molecular Biology of the Cell. 12 (10): 2907–2920. doi:10.1091/mbc.12.10.2907. ISSN   1059-1524. PMC   60144 . PMID   11598180.
2. Mattera, Rafael; Guardia, Carlos M.; Sidhu, Sachdev S.; Bonifacino, Juan S. (2015). "Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex". Journal of Biological Chemistry. 290 (52): 30736–30749. doi: 10.1074/jbc.M115.683409 . PMC   4692204 . PMID   26542808.

• Alberts, Johnson, Lewis, Raff, Roberts, Walter: Molecular Biology of the Cell, 4th edition (2002), Garland Science.
• Hirst, J. D.; Barlow, L; Francisco, GC; Sahlender, DA; Seaman, MNJ; Dacks, JB; et al. (2011). "The Fifth Adaptor Protein Complex". PLOS Biology. 9 (10) e1001170. doi: 10.1371/journal.pbio.1001170 . PMC   3191125 . PMID   22022230.