| Language | Speakers | Status | Comments | Ref |
|---|
| Acatepec Mazatec language, Acatepec Mazatec [1] | | Vulnerable | | |
| Akatek language, Akatek [1] | | Vulnerable | | |
| Awakatek language, Awakatek [1] | | Critically endangered | | |
| Ayapanec language, Ayapanec [1] | | Critically endangered | | |
| Ayapenaco language, Ayapenaco [1] | | Critically endangered | | |
| Ayautla Mazatec language, Ayautla Mazatec [1] | | Vulnerable | | |
| Central Cuicatec language, Central Cuicatec [1] | | Vulnerable | | |
| Central Náhuatl language, Central Náhuatl [1] | | Vulnerable | | |
| Central Otomí language, Central Otomí [1] | | Definitely endangered | | |
| Central Pame language, Central Pame [1] | | Vulnerable | | |
| Central Popoloc language, Central Popoloc [1] | | Severely endangered | | |
| Central Tlapanec language, Central Tlapanec [1] | | Vulnerable | | |
| Central Zoque language, Central Zoque [1] | | Definitely endangered | | |
| Chatino of the western lowlands [1] | | Definitely endangered | | |
| Chatino of Zacatepec language, Chatino of Zacatepec [1] | | Definitely endangered | | |
| Chichimec language, Chichimec [1] | | Vulnerable | | |
| Chihuahua Lower Pima language, Chihuahua Lower Pima [1] | | Definitely endangered | | |
| Chilchotla Mazatec language, Chilchotla Mazatec [1] | | Vulnerable | | |
| Chiquihuitlán Mazatec language, Chiquihuitlán Mazatec [1] | | Definitely endangered | | |
| Chontal Tabasco language, Chontal Tabasco [1] | | Severely endangered | | |
| Chuj language, Chuj [1] | | Critically endangered | | |
| Cocopa language, Cocopa [1] | | Definitely endangered | | |
| Eastern Chocho language, Eastern Chocho [1] | | Severely endangered | | |
| Eastern Cuicatec language, Eastern Cuicatec [1] | | Vulnerable | | |
| Eastern Mazahua language, Eastern Mazahua [1] | | Definitely endangered | | |
| Eastern Popoloc language, Eastern Popoloc [1] | | Vulnerable | | |
| Eastern Tlapanec language, Eastern Tlapanec [1] | | Vulnerable | | |
| Eloxochitlán Mazatec language, Eloxochitlán Mazatec [1] | | Vulnerable | | |
| Filomeno Mata Totonac language, Filomeno Mata Totonac [1] | | Vulnerable | | |
| Higher Reservoir Mazatec language, Higher Reservoir Mazatec [1] | | Vulnerable | | |
| Highland Chontal language, Highland Chontal [1] | | Severely endangered | | |
| Highland Mazatec language, Highland Mazatec [1] | | Vulnerable | | |
| Huasteca Náhuatl language, Huasteca Náhuatl [1] | | Vulnerable | | |
| Huehuetla Tepehua language, Huehuetla Tepehua [1] | | Definitely endangered | | |
| Huehuetlán Mazatec language, Huehuetlán Mazatec [1] | | Vulnerable | | |
| Huichol language, Huichol [1] | | Vulnerable | | |
| Isthmus Náhuatl language, Isthmus Náhuatl [1] | | Vulnerable | | |
| Ixcatec language, Ixcatec [1] | | Critically endangered | | |
| Ixcatlán Mazatec language, Ixcatlán Mazatec [1] | | Vulnerable | | |
| Ixil language, Ixil [1] | | Critically endangered | | |
| Ixtenco Otomí language, Ixtenco Otomí [1] | | Severely endangered | | |
| Jakaltek language, Jakaltek [1] | | Severely endangered | | |
| Kʼicheʼ language, Kʼicheʼ [1] | | Definitely endangered | | |
| Kaqchikel language, Kaqchikel [1] | | Critically endangered | | |
| Kickapoo language, Kickapoo [1] | | Critically endangered | | |
| Kiliwa language, Kiliwa [1] | | Critically endangered | | |
| Lacandón language, Lacandón [1] | | Critically endangered | | |
| Lower Mixe language, Lower Mixe [1] | | Vulnerable | | |
| Lower Northwestern Otomí language, Lower Northwestern Otomí [1] | | Vulnerable | | |
| Lowland Chontal language, Lowland Chontal [1] | | Critically endangered | | |
| Lowland Mazatec language, Lowland Mazatec [1] | | Vulnerable | | |
| Malinaltepec Tlapanec language, Malinaltepec Tlapanec [1] | | Vulnerable | | |
| Mam language, Mam [1] | | Severely endangered | | |
| Matlatzinca language, Matlatzinca [1] | | Definitely endangered | | |
| Mayo language, Mayo [1] | | Critically endangered | | |
| Mazatlán Mazatec language, Mazatlán Mazatec [1] | | Vulnerable | | |
| Mezquital Otomí language, Mezquital Otomí [1] | | Definitely endangered | | |
| Misantla Totonac language, Misantla Totonac [1] | | Critically endangered | | |
| Mixtec of San Miguel Piedras language, Mixtec of San Miguel Piedras [1] | | Severely endangered | | |
| Mixtec of San Pedro Tidaá language, Mixtec of San Pedro Tidaá [1] | | Severely endangered | | |
| Mixtec of Santa Cruz Itundujia language, Mixtec of Santa Cruz Itundujia [1] | | Definitely endangered | | |
| Mixtec of Santa Inés de Zaragoza language, Mixtec of Santa Inés de Zaragoza [1] | | Definitely endangered | | |
| Mixtec of the central Ravine [1] | | Definitely endangered | | |
| Mixtec of the northeast lowlands [1] | | Severely endangered | | |
Mixtec of the Puebla-Oaxaca border [1] (several Mixtec languages go by this name; UNESCO intends Chazumba Mixtec) | | Definitely endangered | | |
| Mixtec of the southwest of Puebla [1] | | Definitely endangered | | |
| Mixtec of Tlaltempan language, Mixtec of Tlaltempan [1] | | Definitely endangered | | |
| Mixtec of Villa de Tututepec language, Mixtec of Villa de Tututepec [1] | | Definitely endangered | | |
| Mixtec of Zapotitlán language, Mixtec of Zapotitlán [1] | | Severely endangered | | |
| Motocintlec language, Motocintlec [1] | | Critically endangered | | |
| Mountain Guarijío language, Mountain Guarijío [1] | | Vulnerable | | |
| Northern Cuicatec language, Northern Cuicatec [1] | | Vulnerable | | |
| Northern Pame language, Northern Pame [1] | | Definitely endangered | | |
| Northern Popoloc language, Northern Popoloc [1] | | Vulnerable | | |
| Northern Tepehuán language, Northern Tepehuán [1] | | Definitely endangered | | |
| Northern Tlapanec language, Northern Tlapanec [1] | | Vulnerable | | |
| Northern Totonac language, Northern Totonac [1] | | Critically endangered | | |
| Northwestern Otomí language, Northwestern Otomí [1] | | Vulnerable | | |
| Northwestern Tarahumara language, Northwestern Tarahumara [1] | | Vulnerable | | |
| Northwestern Tlapanec language, Northwestern Tlapanec [1] | | Vulnerable | | |
| Oʼodham language, Oʼodham [1] | | Definitely endangered | | |
| Ocopetatillo Mazatec language, Ocopetatillo Mazatec [1] | | Vulnerable | | |
| Ocoyoacac Otomí language, Ocoyoacac Otomí [1] | | Severely endangered | | |
| Olultecan language, Olultecan [typo] [1] | | Severely endangered | | |
| Ozumatlán Totonac language, Ozomatlán Totonac [1] | | Critically endangered | | |
| Paipai language, Paipai [1] | | Severely endangered | | |
| Papantla Totonac language, Papantla Totonac [1] | | Definitely endangered | | |
| Patla-Chicontla Totonac language, Patla-Chicontla Totonac [1] | | Severely endangered | | |
| Purépecha language, Purépecha [1] | | Vulnerable | | |
| Pisaflores Tepehua language, Pisaflores Tepehua [1] | | Vulnerable | | |
| Puebla Mazatec language, Puebla Mazatec [1] | | Vulnerable | | |
| River Guarijío language, River Guarijío [1] | | Vulnerable | | |
| San Dionisio del Mar Huave language, San Dionisio del Mar Huave [1] | | Definitely endangered | | |
| San Francisco del Mar Huave language, San Francisco del Mar Huave [1] | | Critically endangered | | |
| San Mateo del Mar Huave language, San Mateo del Mar Huave [1] | | Vulnerable | | |
| Santa María del Mar Huave language, Santa María del Mar Huave [1] | | Severely endangered | | |
| Sayultec language, Sayultec [1] | | Definitely endangered | | |
| Seri language, Seri [1] | | Vulnerable | | |
| Sierra de Puebla Nahuatl language, Sierra de Puebla Náhuatl [1] | | Definitely endangered | | |
| Sierra Otomí language, Sierra Otomí [1] | | Vulnerable | | |
| Sierra Popoluca language, Sierra Popoluca [1] | | Vulnerable | | |
| Sierra Totonac language, Sierra Totonac [1] | | Severely endangered | | |
| Sonora Lower Pima language, Sonora Lower Pima [1] | | Severely endangered | | |
| Southeastern Tarahumara language, Southeastern Tarahumara [1] | | Vulnerable | | |
| Southern Chocho language, Southern Chocho [1] | | Severely endangered | | |
| Southern Tlapanec language, Southern Tlapanec [1] | | Severely endangered | | |
| Southern Zoque language, Southern Zoque [1] | | Definitely endangered | | |
| Southwestern Tepehuan language, Southwestern Tepehuan [1] | | Vulnerable | | |
| Southwestern Tlapanec language, Southwestern Tlapanec [1] | | Vulnerable | | |
| Soyaltepec Mazatec language, Soyaltepec Mazatec [1] | | Vulnerable | | |
| Tabasco Náhuatl language, Tabasco Náhuatl [1] | | Critically endangered | | |
| Tecóatl Mazatec language, Tecóatl Mazatec [1] | | Vulnerable | | |
| Teko language, Teko [1] | | Severely endangered | | |
| Texistepecan language, Texistepecan [1] | | Severely endangered | | |
| Tilapa Otomí language, Tilapa Otomí [1] | | Severely endangered | | |
| Tipai language, Tipai [1] | | Severely endangered | | |
| Tlachichilco Tepehua language, Tlachichilco Tepehua [1] | | Definitely endangered | | |
| Tlahuica language, Tlahuica [1] | | Severely endangered | | |
| Tuzantec language, Tuzantec [1] | | Critically endangered | | |
| Valle Nacional Chinantec language, Valle Nacional Chinantec [1] | | Definitely endangered | | |
| Western Chocho language, Western Chocho [1] | | Severely endangered | | |
| Western Mazahua language, Western Mazahua [1] | | Definitely endangered | | |
| Western Mazatec language, Western Mazatec [1] | | Vulnerable | | |
| Western Náhuatl language, Western Náhuatl [1] | | Severely endangered | | |
| Western Otomí language, Western Otomí [1] | | Severely endangered | | |
| Western Popoloc language, Western Popoloc [1] | | Severely endangered | | |
| Western Tarahumara language, Western Tarahumara [1] | | Vulnerable | | |
| Western Tlapanec language, Western Tlapanec [1] | | Vulnerable | | |
| Western Zoque language, Western Zoque [1] | | Vulnerable | | |
| Yaqui language, Yaqui [1] | | Vulnerable | | |
| Zapotec of Asunción Tlacolulita language, Zapotec of Asunción Tlacolulita [1] | | Critically endangered | | |
| Zapotec of Mixtepe language, Zapotec of Mixtepe [1] | | Critically endangered | | |
| Zapotec of Petapa language, Zapotec of Petapa [1] | | Definitely endangered | | |
| Zapotec of San Antonino el Alto language, Zapotec of San Antonino el Alto [1] | | Definitely endangered | | |
| Zapotec of San Bartolo Yautepec language, Zapotec of San Bartolo Yautepec [1] | | Severely endangered | | |
| Zapotec of San Felipe Tejalapan language, Zapotec of San Felipe Tejalapan [1] | | Critically endangered | | |
| eastern lowlands Zapotec of the Southern mountains [1] | | Definitely endangered | | |
| northeast Zapotec of the Southern mountains [1] | | Definitely endangered | | |
| northwest lowlands Zapotec of the Southern mountains [1] | | Definitely endangered | | |
| north Zapotec of the Valleys [1] | | Severely endangered | | |
| central Zapotec of the Valleys [1] | | Severely endangered | | |
| middle northwest Zapotec of the Valleys [1] | | Definitely endangered | | |
| west Zapotec of the Valleys [1] | | Definitely endangered | | |
| Zapotec of Zimatlán de Álvarez language, Zapotec of Zimatlán de Álvarez [1] | | Definitely endangered | | |
|