Nicotinate dehydrogenase

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nicotinate dehydrogenase
Identifiers
EC no. 1.17.1.5
CAS no. 9059-03-4
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In enzymology, a nicotinate dehydrogenase (EC 1.17.1.5) is an enzyme that catalyzes the chemical reaction

Contents

Nicotinate dehydrogenase.svg
nicotinate + H2O + NADP+ 6-hydroxynicotinate + NADPH + H+

The 3 substrates of this enzyme are nicotinate, H2O, and NADP+, whereas its 3 products are 6-hydroxynicotinate, NADPH, and H+.

Classification

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with NAD+ or NADP+ as acceptor.

Nomenclature

The systematic name of this enzyme class is nicotinate:NADP+ 6-oxidoreductase (hydroxylating). Other names in common use include nicotinic acid hydroxylase, and nicotinate hydroxylase.

Biological role

This enzyme participates in nicotinate and nicotinamide metabolism. It has 2 cofactors: FAD, and Iron.

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References