Oxalate oxidase

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oxalate oxidase
2ete.jpg
Oxalate oxidase 1 dimer, Barley
Identifiers
EC no. 1.2.3.4
CAS no. 9031-79-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, oxalate oxidase (EC 1.2.3.4) is an oxalate degrading enzyme that catalyzes the chemical reaction:

 
O2
H2O2
Oxalate oxidase
O2
H2O2
 
2 CO2
 

The two substrates of this enzyme are oxalic acid and oxygen. Its products are carbon dioxide and hydrogen peroxide. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with oxygen as acceptor. The systematic name of this enzyme class is oxalate:oxygen oxidoreductase. Other names in common use include aero-oxalo dehydrogenase, and oxalic acid oxidase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It uses Manganese as a cofactor. [4]

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1FI2, 2ET1, 2ET7, and 2ETE.

References

  1. Enzyme 1.2.3.4 at KEGG Pathway Database.
  2. DATTA PK, MEEUSE BJ (1955). "Moss oxalic acid oxidase-a flavoprotein". Biochim. Biophys. Acta. 17 (4): 602–3. doi: 10.1016/0006-3002(55)90436-4 . PMID   13250021.
  3. Kotsira VP, Clonis YD (1997). "Oxalate oxidase from barley roots: purification to homogeneity and study of some molecular, catalytic, and binding properties". Arch. Biochem. Biophys. 340 (2): 239–49. doi:10.1006/abbi.1997.9896. PMID   9143327.
  4. Requena L, Bornemann S (1999). "Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme". Biochem. J. 343 (Pt 1): 185–90. doi:10.1042/bj3430185. PMC   1220540 . PMID   10493928.