Paragonimus

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Paragonimus
Paragonimus westermani 01.jpg
Egg of Paragonimus westermani
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Platyhelminthes
Class: Trematoda
Order: Plagiorchiida
Family: Paragonimidae
Dollfus, 1939
Genus: Paragonimus
Braun, 1899  [1]
Species

Paragonimus is a genus of flukes (trematodes) and is the only genus in the monotypic family Paragonimidae. Some tens of species have been described, but they are difficult to distinguish, so it is not clear how many of the named species may be synonyms. The name Paragonimus is derived from the combination of two Greek words, “para” (on the side of) and “gonimos” (gonads or genitalia). [3] Several of the species are known as lung flukes. In humans some of the species occur as zoonoses; the term for the condition is paragonimiasis. The first intermediate hosts of Paragonimus include at least 54 species of freshwater snails from superfamilies Cerithioidea and Rissooidea. [2]

Contents

The most prominent species of Paragonimus in human medicine is Paragonimus westermani , an infectious lung fluke originating in eastern Asia. Worldwide, about nine species of Paragonimus are known to cause human paragonimiasis in which many of the species reside in East Asia, West Africa, and in North and South America. [4]

Morphology

Morphology of typical Paragonimus:
AC: acetabulum (ventral sucker)
CE: cecum, EB: excretory bladder
OS: oral sucker, OV: ovary
TE: testes, UT: uterus Paragonimus westermani adult.jpg
Morphology of typical Paragonimus:
AC: acetabulum (ventral sucker)
CE: cecum, EB: excretory bladder
OS: oral sucker, OV: ovary
TE: testes, UT: uterus

Species of Paragonimus vary in size; the adult stage might attain a length of up to 15 millimetres (0.59 in) and a width of up to 8 mm (0.31 in). [5] The adult flatworm has an oval shape body with spines covering its thick tegument. Both the oral sucker and acetabulum are round and muscular. The acetabulum is slightly bigger than the oral sucker – 0.19 mm and 0.12 mm, respectively. [5] Ovaries are located behind the acetabulum and posterior to the ovary are the testes. The seminal receptacle, the uterus and its metraterm, the thick-walled terminal part, lie between the acetabulum and the ovary. [5]

Life cycle

The parasite passes through two intermediate hosts, an aquatic snail and a crustacean. It enters its mammalian definitive hosts when they eat infected freshwater crustaceans. Typical hosts include dogs, cats, and humans. Humans usually contract paragonimiasis when they eat undercooked freshwater crabs (for instance species of the genus Nanhaipotamon ) or crayfish, that contain live metacercariae. In the intestine, the parasite will move into the abdomen and commonly into the lungs. In the lung, the parasites encyst and cross fertilize each other. The cyst eventually ruptures in the lungs and the eggs may be coughed up or swallowed and excreted in the feces. An egg landing in fresh water hatches and releases a ciliated miracidium. A successful miracidium swims about until it finds an intermediate host, usually an aquatic snail. A crustacean in turn becomes infected by eating infected snails. The definitive host completes the cycle if it eats infected crustaceans.[ citation needed ]

Epidemiology

Worldwide roughly 20 million people are infected with Paragonimus. Human infections are most common in regions with many human and animal reservoir hosts plus an abundance of intermediate hosts, such as snails, crabs, or crayfish, and where in addition consumption of raw or undercooked seafood is common. Consumption of insufficiently cooked meat from infected land animal hosts, such as wild boar, commonly transmits the infection. [6] The domestic cat is a reservoir for a variety of lung flatworms and can transmit the infection to humans.

Symptoms

Symptoms of paragonimiasis may include abdominal pain, diarrhea, fever, and hives. If the infection remains untreated, the symptoms may diminish or disappear after only few months, but sometimes they last for decades. [7] Paragonimiasis is caused by the body's natural immune response to the worms and eggs that are present and also migrating from the intestines to the lungs.[ citation needed ]

As a rule, the parasites begin to cause symptoms about three weeks after ingesting live metacercariae. After about eight weeks, they begin to produce eggs in the lungs. Some patients develop brain damage if parasites establish in the brain and produce eggs. The brain damage commonly causes headache, vomiting, and seizures. [4] Untreated cerebral paragonimaisis commonly results in death from increased intracranial pressure.

Treatment

Praziquantel has been used to effectively treat paragonimiasis by separating the tegument. An effectively complete rate of cure may be expected after three days of treatment if there has not been too much permanent damage, such as from intracranial effects. [8] Other medications can also be used such as bithionol, niclofan, and triclabendazole with high cure rates.[ citation needed ]

Prevention

Thorough cooking of an infected crustacean kills all stages of the parasite. Crab meat should not be eaten raw, even if pickled, because the pickling solution often fails to kill all the parasites. Utensils and cutlery boards should be cleaned thoroughly before and after food preparation. [4]

Related Research Articles

<span class="mw-page-title-main">Trematoda</span> Class of parasitic flatworms

Trematoda is a class of flatworms known as flukes or trematodes. They are obligate internal parasites with a complex life cycle requiring at least two hosts. The intermediate host, in which asexual reproduction occurs, is usually a snail. The definitive host, where the flukes sexually reproduce, is a vertebrate. Infection by trematodes can cause disease in all five traditional vertebrate classes: mammals, birds, amphibians, reptiles, and fish.

<i>Clonorchis sinensis</i> Species of fluke

Clonorchis sinensis, the Chinese liver fluke, is a liver fluke belonging to the class Trematoda, phylum Platyhelminthes. It infects fish-eating mammals, including humans. In humans, it infects the common bile duct and gall bladder, feeding on bile. It was discovered by British physician James McConnell at the Medical College Hospital in Calcutta (Kolkata) in 1874. The first description was given by Thomas Spencer Cobbold, who named it Distoma sinense. The fluke passes its lifecycle in three different hosts, namely freshwater snail as first intermediate hosts, freshwater fish as second intermediate host, and mammals as definitive hosts.

<span class="mw-page-title-main">Digenea</span> Class of flukes

Digenea is a class of trematodes in the Platyhelminthes phylum, consisting of parasitic flatworms with a syncytial tegument and, usually, two suckers, one ventral and one oral. Adults commonly live within the digestive tract, but occur throughout the organ systems of all classes of vertebrates. Once thought to be related to the Monogenea, it is now recognised that they are closest to the Aspidogastrea and that the Monogenea are more closely allied with the Cestoda. Around 6,000 species have been described to date.

<span class="mw-page-title-main">Clonorchiasis</span> Infectious disease caused by fish parasites

Clonorchiasis is an infectious disease caused by the Chinese liver fluke and two related species. Clonorchiasis is a known risk factor for the development of cholangiocarcinoma, a neoplasm of the biliary system.

<i>Fasciola hepatica</i> Species of fluke

Fasciola hepatica, also known as the common liver fluke or sheep liver fluke, is a parasitic trematode of the class Trematoda, phylum Platyhelminthes. It infects the livers of various mammals, including humans, and is transmitted by sheep and cattle to humans the world over. The disease caused by the fluke is called fasciolosis or fascioliasis, which is a type of helminthiasis and has been classified as a neglected tropical disease. Fasciolosis is currently classified as a plant/food-borne trematode infection, often acquired through eating the parasite's metacercariae encysted on plants. F. hepatica, which is distributed worldwide, has been known as an important parasite of sheep and cattle for decades and causes significant economic losses in these livestock species, up to £23 million in the UK alone. Because of its relatively large size and economic importance, it has been the subject of many scientific investigations and may be the best-known of any trematode species. F. hepatica's closest relative is Fasciola gigantica. These two flukes are sister species; they share many morphological features and can mate with each other.

<i>Paragonimus westermani</i> Species of fluke

Paragonimus westermani is the most common species of lung fluke that infects humans, causing paragonimiasis. Human infections are most common in eastern Asia and in South America. Paragonimiasis may present as a sub-acute to chronic inflammatory disease of the lung. It was discovered by Coenraad Kerbert (1849–1927) in 1878.

<i>Echinostoma</i> Genus of flukes

Echinostoma is a genus of trematodes (flukes), which can infect both humans and other animals. These intestinal flukes have a three-host life cycle with snails or other aquatic organisms as intermediate hosts, and a variety of animals, including humans, as their definitive hosts.

<span class="mw-page-title-main">Paragonimiasis</span> Medical condition

Paragonimiasis is a food-borne parasitic disease caused by several species of lung flukes belonging to genus Paragonimus. Infection is acquired by eating crustaceans such as crabs and crayfishes which host the infective forms called metacercariae, or by eating raw or undercooked meat of mammals harboring the metacercariae from crustaceans.

<i>Fasciolopsis</i> Genus of flukes

Fasciolopsis is a genus of trematodes. They are also known as giant intestinal flukes.

<i>Echinostoma revolutum</i> Species of fluke

Echinostoma revolutum is a trematode parasites, of which the adults can infect birds and mammals, including humans. In humans, it causes echinostomiasis.

<i>Heterophyes heterophyes</i> Species of fluke

Heterophyes heterophyes, or the intestinal fish fluke, was discovered by Theodor Maximaillian Bilharz in 1851. This parasite was found during an autopsy of an Egyptian mummy. H. heterophyes is found in the Middle East, West Europe and Africa. They use different species to complete their complex lifestyle. Humans and other mammals are the definitive host, first intermediate host are snails, and second intermediate are fish. Mammals that come in contact with the parasite are dogs, humans, and cats. Snails that are affected by this parasite are the Cerithideopsilla conica. Fish that come in contact with this parasite are Mugil cephalus, Tilapia milotica, Aphanius fasciatus, and Acanthgobius sp. Humans and mammals will come in contact with this parasite by the consumption of contaminated or raw fish. This parasite is one of the smallest endoparasite to infect humans. It can cause intestinal infection called heterophyiasis.

<i>Clinostomum marginatum</i> Species of fluke

Clinostomum marginatum is a species of parasitic fluke. It is commonly called the "yellow grub". It is found in many freshwater fish in North America, and no fish so far is immune to this parasite. It is also found in frogs. Clinostomum marginatum can also be found in the mouth of aquatic birds such as herons and egrets. They are commonly present in the esophagus of fish-eating birds and reptiles. Eggs of these trematodes are shed in the feces of aquatic birds and released into water. Aquatic birds become hosts of this parasite by ingesting infected freshwater fish. The metacercariae are found right beneath the skin or in the muscles of host fish.

Megalodiscus temperatus is a Digenean in the phylum Platyhelminthes. This parasite belongs to the Cladorchiidae family and is a common parasite located in the urinary bladder and rectum of frogs. The primary host is frogs and the intermediate hosts of Megalodiscus temeperatus are freshwater snails in the genus Helisoma.

<i>Philophthalmus gralli</i> Species of fluke

Philophthalmus gralli, commonly known as the Oriental avian eye fluke, parasitises the conjunctival sac of the eyes of many species of birds, including birds of the orders Galliformes and Anseriformes. In Brazil this parasite was reported in native Anseriformes species. It was first discovered by Mathis and Leger in 1910 in domestic chickens from Hanoi, Vietnam. Birds are definitive hosts and freshwater snail species are intermediate hosts. Human cases of philophthalmosis are rare, but have been previously reported in Europe, Asia, and America.

<i>Alaria</i> (trematode) Genus of flukes

Alaria is a genus of flatworms, or trematodes, in the family Diplostomidae.

Paragonimus kellicotti, the North American lung fluke, is a species of parasitic trematode in the genus Paragonimus. This species of Paragonimus has an intricate lifecycle, and although its name may suggest that it is only a health concern in North America, it is also prominent in Southeast Asia and China.

Paragonimus skrjabini is classified as a species in the genus Paragonimus, which consists of many species of lung flukes that result in the food-borne parasitic disease paragonimiasis.

<i>Metagonimus yokogawai</i> Species of fluke

Metagonimus yokogawai, or the Yokogawa fluke, is a species of a trematode, or fluke worm, in the family Heterophyidae.

<span class="mw-page-title-main">Trematodiasis</span> Medical condition

Trematodiasis is a group of parasitic infections due different species of flukes, the trematodes. Symptoms can range from mild to severe depending on the species, number and location of trematodes in the infected organism. Symptoms depend on type of trematode present, and include chest and abdominal pain, high temperature, digestion issues, cough and shortness of breath, diarrhoea and change in appetite.

<span class="mw-page-title-main">Gastropod-borne parasitic disease</span> Medical condition

Gastropod-borne parasitic diseases (GPDs) are a group of infectious diseases that require a gastropod species to serve as an intermediate host for a parasitic organism that can infect humans upon ingesting the parasite or coming into contact with contaminated water sources. These diseases can cause a range of symptoms, from mild discomfort to severe, life-threatening conditions, with them being prevalent in many parts of the world, particularly in developing regions. Preventive measures such as proper sanitation and hygiene practices, avoiding contact with infected gastropods and cooking or boiling food properly can help to reduce the risk of these diseases.

References

  1. M. Braun (1899). "Über Clinostomum Leidy". Zoologischer Anzeiger . 22 (603): 489–493.
  2. 1 2 G. M. Davis; C. E. Chen; Z. B. Kang; Y. Y. Liu (1994). "Snail hosts of Paragonimus in Asia and the Americas". Biomedical and Environmental Sciences. 7 (4): 369–382. PMID   7535537.
  3. G. W. Procop (2009). "North American Paragonimiasis (caused by Paragonimus kellicotti) in the Context of Global Paragonimiasis". Clinical Microbiology Reviews . 22 (3): 415–446. doi:10.1128/cmr.00005-08. PMC   2708389 . PMID   19597007.
  4. 1 2 3 Gary W. Procop (2009). "North American paragonimiasis (caused by Paragonimus kellicotti) in the context of global paragonimiasis". Clinical Microbiology Reviews . 22 (3): 415–446. doi:10.1128/CMR.00005-08. PMC   2708389 . PMID   19597007.
  5. 1 2 3 Imelda Vélez, Luz E. Velásquez and Iván D. Vélez (2003). "Morphological description and life cycle of Paragonimus sp. (Trematoda: Troglotrematidae): causal agent of human paragonimiasis in Colombia". Journal of Parasitology . 89 (4): 749–755. doi:10.1645/ge-2858. JSTOR   3285872. PMID   14533686. S2CID   8120364.
  6. Karin Leder; Peter F Weller. "Paragonimiasis". UpToDate. Archived from the original on 21 August 2016. Retrieved 15 May 2014.
  7. "Paragonimiasis (lung fluke)" (PDF). August 2006. Archived from the original (PDF) on 11 December 2011. Retrieved 8 December 2011.
  8. Nawa Yukifumi (2000). "Re-emergence of paragonimiasis". Internal Medicine . 39 (5): 353–354. doi: 10.2169/internalmedicine.39.353 . PMID   10830172.