Feline zoonosis

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Feline zoonosis
Kitten kiss.jpg
Specialty Infectious disease, veterinary medicine

A feline zoonosis is a viral, bacterial, fungal, protozoan, nematode or arthropod infection that can be transmitted to humans from the domesticated cat, Felis catus. Some of these diseases are reemerging and newly emerging infections or infestations caused by zoonotic pathogens transmitted by cats. In some instances, the cat can display symptoms of infection (these may differ from the symptoms in humans) and sometimes the cat remains asymptomatic. There can be serious illnesses and clinical manifestations in people who become infected. This is dependent on the immune status and age of the person. Those who live in close association with cats are more prone to these infections, but those that do not keep cats as pets can also acquire these infections as the transmission can be from cat feces and the parasites that leave their bodies. [1]

Contents

People can acquire cat-associated infections through bites, scratches or other direct contact of the skin or mucous membranes with the cat. This includes 'kissing' or letting the animal lick the mouth or nose. Mucous membranes are easily infected when the pathogen is in the mouth of the cat. Pathogens can also infect people when there is contact with animal saliva, urine and other body fluids or secretions. When fecal material is unintentionally ingested, infection can occur. A feline zoonosis can be acquired by a person by inhalation of aerosols or droplets coughed up by the cat. [2] [3]

In the United States, thirty-two percent of homes have at least one cat. [4] Some contagious infections such as campylobacteriosis and salmonellosis cause visible symptoms of the disease in cats. Other infections, such as cat scratch disease and toxoplasmosis, have no visible symptoms and are carried by apparently healthy cats. [5]

Cats as vectors

Some disease-carrying arthropods use cats as a vector, or carrier. Fleas and ticks can carry pathogenic organisms that infect a person with Lyme disease, tick-borne encephalitis, and Rocky mountain spotted fever. [1]

Bites

Statistics generated by the state of Ohio document that cat bites make up about 20 percent of all animal bites each year. Bites from cats can not only transmit serious diseases such as rabies, but bites can develop bacterial infections. The bite of a cat appears small but it can be deep. As many as 80 percent of cat bites become infected. [5] [6]

Viral

Cowpox infection Cowpox eruption.jpg
Cowpox infection

In 2010, over 400 cases of cowpox infection from cats to human have been described. The symptoms differ between both humans and cats. In people, local exanthema appears on the arms and face. The infection resolves on its own but those who are immunosuppressed can progress to systemic infection that closely resembles smallpox. When the infection has expanded to severe symptoms, it can be lethal. The signs of cowpox infection in cats can be seen as, multiple skin sores on the paws, neck, head and mouth. The cat can also develop a purulent discharge from the eyes. Necrotizing pneumonia has also been observed. Estimates that 50% of human cases of cowpox are due to transmission from cats in the United Kingdom. [1]

The avian flu virus H7N2 has been found in cats in New York City. [7] Though transmission to people is possible, it is thought to be rare. [8] [9] In Europe, cats were identified as being hosts for West Nile virus. [10]

Bacterial

Pasteurella multocida

The bacterium Pasteurella multocida and its genus can pose a risk of severe diseases in high-risk groups such as the elderly, transplant recipients, cancer patients and immunocompromised individuals. Transmission of the infection to the human from the cat has been attributed to kissing the cat, providing care that exposes the person to the body fluids of the cat and sleeping with the cat. [1] [3]

Capnocytophaga canimorsus

The bacterium Capnocytophaga canimorsus can pose a risk of severe diseases in high-risk groups such as the elderly, transplant recipients, cancer patients and immunocompromised individuals. Transmission of the infection to the human from the cat has been attributed to kissing the cat, providing care that exposes the person to the body fluids of the cat and sleeping with the cat. [1] [10] [3] Kittens are more likely to transmit the bacterium than adult cats. [10] Exposure to cats with this infection has been associated with meningitis. [11] Capnocytophaga canimorsus sepsis has also been associated with infection in cat owners. [12]

Methicillin-resistant Staphylococcus aureus

MRSA is a common type of bacteria that is normally found on the skin of people and cats. [1] Methicillin-resistant Staphylococcus aureus (MRSA) is the same bacterium that has become resistant to some antibiotics. Cats and other animals often can carry MRSA without being sick, but MRSA can cause a variety of infections, including of the skin, respiratory tract, and urinary tract of people. MRSA can be transmitted back and forth between people and animals through direct contact. In people, MRSA most often causes skin infections that can range from mild to severe. If left untreated, MRSA can spread to the bloodstream or lungs and cause life-threatening infections. [13] [2] [3]

Plague

Cats are known to transmit plague. Plague can take three forms: bubonic plague, primary septicemic plague, and primary pneumonic plague. [12] [14]

Chagas disease

Transmission of Chagas disease has been documented and is associated with sleeping with cats. [12]

Leishmaniasis

Leishmaniasis is a newly emerging pathogen in Texas. [1]

Staphylococcus intermedius

The Staphylococcus intermedius bacteria, a common commensal on cats, is associated with infection in humans. [12]

Leptospirosis

Leptospirosis infection associated with cat urine has been identified as an emerging bacterial pathogen in some European countries. In infected humans, jaundice may or may not be a symptom. If jaundice is a symptom the infection becomes more severe and rapidly progresses. [15]

Tuberculosis and influenza

Different strains of the tuberculosis bacterium ( Mycobacterium bovis , M. tuberculosis and M. microti ) have been isolated from cats and associated with infection with the presence of the bacterium in their owners, but a definitive cause has not been established. Neither has one strain of influenza been proven to infect pet owners, though infected cats can infect other cats. [1]

Kennel cough

Bordetella bronchiseptica has been identified in cats with owners that also are infected with this pathogen. Individuals having this infection have usually been cancer or transplant patients. Those with this infection can develop serious pneumonia. [1]

Echinococcosis

Echinococcus multilocularis can infect cats and then be transmitted to their owners to cause human alveolar echinococcosis. Foxes have transmitted this pathogen to cats in Germany, Austria, France and Japan. [1]

Arthropods

Cheyletiellosis (also known as Cheyletiella dermatitis) is a mild, short-term skin inflammation caused by the mite Cheyletiella blakei that feeds on a person's skin cells. It is spread through contact with infested cats. Cheyletiella blakei infection has been associated with sleeping with a cat. Though not a common ectoparasite, it may be an emerging pathogen in California. The infected cat may have no signs of infection. However, affected kittens may have patches of scaly skin with dandruff. The most common symptoms of cheyletiellosis in people include itching, redness, and raised bumps on areas of the skin that touched the infested animal. Cheyletiellosis in people generally resolves on its own. [13] [15]

Fungi

Cats are reservoirs and are able to transmit mycotic infections. [16] Cats, especially kittens can pass on a Ringworm infection to people. Ringworm is a fungal disease and approximately 40 types of fungi can cause ringworm. They are typically of the Trichophyton , Microsporum , or Epidermophyton type. [17] It gets its name from the characteristic ring-like rash on the skin. The disease is spread by touching an infected cat. The rash may be scaly, reddened, and circular. Ringworm on the scalp usually makes a bald patch of scaly skin. Long-haired cats do not always show signs of ringworm infection. Kittens with ringworm have patches that are hairless, circular, or irregularly shaped areas of scaling, crusting, and redness that may or may not be itchy. The area may not be completely hairless, and instead have brittle, broken hairs. If the claws are affected, they may have a whitish, opaque appearance with shredding of the claw's surface. [18]

Sporotrichosis is a fungal disease that is transmitted by mostly outdoor cats. [1]

Platyhelminthes

The lung fluke Paragonimus westermani Paragonimus westermani 01.jpg
The lung fluke Paragonimus westermani

Paragonimiasis, or lung fluke uses cats as a reservoir and subsequently can transmit the infection to humans. Symptoms in cats have not been observed. There are over nine species of lung flukes that can be transmitted to humans from cats. The disease has been found in Asia, Africa, India, North, South and Central America. It is not uncommon and estimates of those infected are in the millions. Signs symptoms in humans are coughing up blood, migration of the flukes into other body organs including the central nervous system. There it can cause neurological symptoms such as headache, confusion, convulsions, vision problems, and bleeding in the brain. This infection in humans is sometimes mistaken for tuberculosis. [19]

Onchocercosis has been associated with pet cats in a few cases. [1]

Cats can harbor and transmit hookworms to people. [20]

Protozoans

Cryptosporidiosis is a parasitic disease that is transmitted through contaminated food or water from an infected person or animal. Cryptosporidiosis in cats is rare, but they can carry the protozoan without showing any signs of illness. Cryptosporidiosis can cause profuse, watery diarrhea with cramping, abdominal pain, and nausea in people. Illness in people is usually self-limiting and lasts only 2–4 days, but can become severe in people with weakened immune systems. [13] Cryptosporidiosis (Cryptosporidium spp.) Cats transmit the protozoan through their feces. The symptoms in people weight loss and chronic diarrhea in high-risk patients. More than one species of this genus can be acquired by people. Dogs can also transmit this parasite. [2] [12]

Another important protozoan disease associated with cats is Toxoplasma gondii, for which cats act as the definitive reservoir. Infected cats shed oocysts in their faeces, which upon ingestion can infect an individual. Pregnant women are especially at risk as it is associated with miscarriage, hydrocephalus of the newborn, or other symptoms. [21]

Prevention

One strategy for the prevention of infection transmission between cats and people is to better educate people on the behaviour that puts them at risk for becoming infected. [3]

Those at the highest risk of contracting a disease from a cat are those with behaviors that include: being licked, sharing food, sharing kitchen utensils, kissing, and sleeping with a cat. [1] The very young, the elderly and those who are immunocompromised increase their risk of becoming infected when sleeping with their cats (and dogs). The CDC recommends that cat owners not allow a cat to lick your face because it can result in disease transmission. If someone is licked on their face, mucous membranes or an open wound, the risk for infection is reduced if the area is immediately washed with soap and water. Maintaining the health of the animal by regular inspection for fleas and ticks, scheduling deworming medications along with veterinary exams will also reduce the risk of acquiring a feline zoonosis. [12]

Recommendations for the prevention of ringworm transmission to people include:[ citation needed ]

See also

Related Research Articles

A human pathogen is a pathogen that causes disease in humans.

<span class="mw-page-title-main">Zoonosis</span> Disease that can be transmitted from other species to humans

A zoonosis or zoonotic disease is an infectious disease of humans caused by a pathogen that can jump from a non-human to a human and vice versa.

Methicillin-resistant <i>Staphylococcus aureus</i> Bacterium responsible for difficult-to-treat infections in humans

Methicillin-resistant Staphylococcus aureus (MRSA) is a group of gram-positive bacteria that are genetically distinct from other strains of Staphylococcus aureus. MRSA is responsible for several difficult-to-treat infections in humans. It caused more than 100,000 deaths worldwide attributable to antimicrobial resistance in 2019.

Trench fever is a moderately serious disease transmitted by body lice. It infected armies in Flanders, France, Poland, Galicia, Italy, Macedonia, Mesopotamia, Russia and Egypt in World War I. Three noted cases during WWI were the authors J. R. R. Tolkien, A. A. Milne, and C. S. Lewis. From 1915 to 1918 between one-fifth and one-third of all British troops reported ill had trench fever while about one-fifth of ill German and Austrian troops had the disease. The disease persists among the homeless. Outbreaks have been documented, for example, in Seattle and Baltimore in the United States among injection drug users and in Marseille, France, and Burundi.

<span class="mw-page-title-main">Septicemic plague</span> Human disease caused by Yersinia pestis

Septicemic plague is one of the three forms of plague, and is caused by Yersinia pestis, a gram-negative species of bacterium. Septicemic plague is a systemic disease involving infection of the blood and is most commonly spread by bites from infected fleas. Septicemic plague can cause disseminated intravascular coagulation and is always fatal when untreated. The other varieties of the plague are bubonic plague and pneumonic plague.

<i>Rickettsia rickettsii</i> Species of bacterium

Rickettsia rickettsii is a Gram-negative, intracellular, coccobacillus bacterium that was first discovered in 1902. R. rickettsii is the causative agent of Rocky Mountain Spotted Fever and is transferred to its host via a tick bite. It is one of the most pathogenic Rickettsia species and affects a large majority of the Western Hemisphere, most commonly the Americas.

<span class="mw-page-title-main">Natural reservoir</span> Type of population in infectious disease ecology

In infectious disease ecology and epidemiology, a natural reservoir, also known as a disease reservoir or a reservoir of infection, is the population of organisms or the specific environment in which an infectious pathogen naturally lives and reproduces, or upon which the pathogen primarily depends for its survival. A reservoir is usually a living host of a certain species, such as an animal or a plant, inside of which a pathogen survives, often without causing disease for the reservoir itself. By some definitions a reservoir may also be an environment external to an organism, such as a volume of contaminated air or water.

<span class="mw-page-title-main">Animal bite</span> Wound or puncture caused by animal teeth

An animal bite is a wound, usually a puncture or laceration, caused by the teeth. An animal bite usually results in a break in the skin but also includes contusions from the excessive pressure on body tissue from the bite. The contusions can occur without a break in the skin. Bites can be provoked or unprovoked. Other bite attacks may be apparently unprovoked. Biting is a physical action not only describing an attack but it is a normal response in an animal as it eats, carries objects, softens and prepares food for its young, removes ectoparasites from its body surface, removes plant seeds attached to its fur or hair, scratching itself, and grooming other animals. Animal bites often result in serious infections and mortality. Animal bites not only include injuries from the teeth of reptiles, mammals, but fish, and amphibians. Arthropods can also bite and leave injuries.

<i>Dirofilaria immitis</i> Species of worm that causes parasitic disease in animals

Dirofilaria immitis, also known as heartworm or dog heartworm, is a parasitic roundworm that is a type of filarial worm, a small thread-like worm, that causes dirofilariasis. It is spread from host to host through the bites of mosquitoes. There are four genera of mosquitoes that transmit dirofilariasis, Aedes, Culex, Anopheles, and Mansonia. The definitive host is the dog, but it can also infect cats, wolves, coyotes, jackals, foxes, ferrets, bears, seals, sea lions and, under rare circumstances, humans.

<span class="mw-page-title-main">Murine typhus</span> Medical condition

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<i>Cryptosporidium</i> Genus of single-celled organisms

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<span class="mw-page-title-main">Dermatophytosis</span> Fungal infection of the skin

Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Typically it results in a red, itchy, scaly, circular rash. Hair loss may occur in the area affected. Symptoms begin four to fourteen days after exposure. Multiple areas can be affected at a given time.

Rat-bite fever (RBF) is an acute, febrile human illness caused by bacteria transmitted by rodents, in most cases, which is passed from rodent to human by the rodent's urine or mucous secretions. Alternative names for rat-bite fever include streptobacillary fever, streptobacillosis, spirillary fever, bogger, and epidemic arthritic erythema. It is a rare disease spread by infected rodents and caused by two specific types of bacteria:

  1. Streptobacillus moniliformis, the only reported bacteria that causes RBF in North America
  2. Spirillum minus, common in Asia. Most cases occur in Japan, but specific strains of the disease are present in the United States, Europe, Australia, and Africa.
<i>Babesia</i> Genus of protozoan parasites

Babesia, also called Nuttallia, is an apicomplexan parasite that infects red blood cells and is transmitted by ticks. Originally discovered by the Romanian bacteriologist Victor Babeș in 1888, over 100 species of Babesia have since been identified.

Capnocytophaga canimorsus is a fastidious, slow-growing, Gram-negative rod of the genus Capnocytophaga. It is a commensal bacterium in the normal gingival flora of canine and feline species, but can cause illness in humans. Transmission may occur through bites, licks, or even close proximity with animals. C. canimorsus generally has low virulence in healthy individuals, but has been observed to cause severe, even grave, illness in persons with pre-existing conditions. The pathogenesis of C. canimorsus is still largely unknown, but increased clinical diagnoses have fostered an interest in the bacillus. Treatment with antibiotics is effective in most cases, but the most important yet basic diagnostic tool available to clinicians remains the knowledge of recent exposure to canines or felines.

<span class="mw-page-title-main">Rabies in animals</span> Deadly zoonotic disease

In animals, rabies is a viral zoonotic neuroinvasive disease which causes inflammation in the brain and is usually fatal. Rabies, caused by the rabies virus, primarily infects mammals. In the laboratory it has been found that birds can be infected, as well as cell cultures from birds, reptiles and insects. The brains of animals with rabies deteriorate. As a result, they tend to behave bizarrely and often aggressively, increasing the chances that they will bite another animal or a person and transmit the disease.

<span class="mw-page-title-main">Cat-scratch disease</span> Human disease

Cat-scratch disease (CSD) or felinosis is an infectious disease that most often results from a scratch or bite of a cat. Symptoms typically include a non-painful bump or blister at the site of injury and painful and swollen lymph nodes. People may feel tired, have a headache, or a fever. Symptoms typically begin within 3–14 days following infection.

<span class="mw-page-title-main">Cat bite</span> Medical condition

Cat bites are bites inflicted upon humans, other cats, and other animals by the domestic cat. Data from the United States show that cat bites represent between 5–15% of all animal bites inflicted to humans, but it has been argued that this figure could be the consequence of under-reporting as bites made by Felis catus are considered by some to be unimportant. Though uncommon, cat bites can sometimes cause Rabies lead to complications and, very rarely, death.

An occupational infectious disease is an infectious disease that is contracted at the workplace. Biological hazards (biohazards) include infectious microorganisms such as viruses, bacteria and toxins produced by those organisms such as anthrax.

MRSA ST398 is a specific strain of Methicillin-resistant Staphylococcus aureus (MRSA). Staphylococcus aureus is a gram-positive, spherical bacterium that can cause a range of infections in humans and animals. And Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterium that is resistant to many antibiotics. The abbreviation "ST" in MRSA ST398 refers to the sequence type of the bacterium. MRSA ST398 is a clonal complex 398 (CC398). This means that the strain had emerged in a human clinic, without any obvious or understandable causes. MRSA ST398, a specific strain of MRSA, is commonly found in livestock, and can cause infections in humans who come into contact with infected animals.

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