Amblyomma americanum

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Northeastern water tick
Amblyomma americanum tick.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Chelicerata
Class: Arachnida
Order: Ixodida
Family: Ixodidae
Genus: Amblyomma
Species:
A. americanum
Binomial name
Amblyomma americanum
Amblyomma americanum range map.svg
Red indicates where the species is normally found; Blue indicates other locations where the species has been reported
Synonyms

Acarus americanusLinnaeus, 1758

Amblyomma americanum, also known as the lone star tick, the northeastern water tick, or the turkey tick, is a type of tick indigenous to much of the eastern United States and Mexico, that bites painlessly and commonly goes unnoticed, remaining attached to its host for as long as seven days until it is fully engorged with blood. It is a member of the phylum Arthropoda, class Arachnida. [2] The adult lone star tick is sexually dimorphic, named for a silvery-white, star-shaped spot or "lone star" present near the center of the posterior portion of the adult female shield (scutum); adult males conversely have varied white streaks or spots around the margins of their shields. [3] [4]

Contents

A. americanum is also referred to as the turkey tick in some Midwestern U.S. states, where wild turkeys are a common host for immature ticks. [4] Also called the Cricker Tic in Missouri. It is the primary vector of Ehrlichia chaffeensis, which causes human monocytic ehrlichiosis, and Ehrlichia ewingii, which causes human and canine granulocytic ehrlichiosis. [5] It may also cause a person to develop alpha-gal syndrome, an allergy to non-catarrhine mammalian meat. Other disease-causing bacterial agents isolated from lone star ticks include Francisella tularensis, Rickettsia amblyommii, and Coxiella burnetti. [6]

The distribution of the lone star tick (Amblyomma americanum) in the United States Lone-star-tick-map-cdc.jpg
The distribution of the lone star tick (Amblyomma americanum) in the United States

Range and habitat

The lone star tick is widely distributed across the East, Southeast, and Midwest United States. [3] [7] It lives in wooded areas, particularly in second-growth forests with thick underbrush, where white-tailed deer (the primary host of mature ticks) reside. [4] [7] [8] Lone star ticks can also be found in ecotonal areas (transition zones between different biomes) such as those between forest and grassland ecosystems. [7] [8] The lone star tick uses thick underbrush or high grass to attach to its host by way of questing. Questing is an activity in which the tick climbs up a blade of grass or to the edges of leaves and stretches its front legs forward, in response to stimuli from biochemicals such as carbon dioxide or heat and vibration from movement, and mounts the passing host as it brushes against the tick's legs. [9] Once attached to its host, the tick is able to move around and select a preferred feeding site. [4]

The tick has also been reported outside of its range in Canada, in areas of Southern Ontario, including in London, Wellington County, and the Region of Waterloo. [10]

Development

Development of the lone star tick (A. americanum) Lone-star-tick-stages-cdc.jpg
Development of the lone star tick (A. americanum)

The tick follows the normal developmental stages of egg, larva, nymph, and adult. It is known as a three-host tick, meaning that it feeds from a different host during each of the larval, nymphal, and adult stages. The lone star tick attaches itself to a host by way of questing. [11] The eggs are laid on the ground, hatch, and the larvae wait for or actively seek a host (questing behavior). A larva feeds, detaches from its host, molts into a nymph when on the ground, and quests by crawling on the ground or waiting on vegetation. The nymph feeds and repeats the same process as the larva, but emerges having developed the anatomy of either an adult female or male. Adults quest similarly to nymphs. The female attaches only to a species of host for reproduction. The female engorges on much blood, expanding greatly, then detaches and converts the blood meal into eggs, which are laid on the ground. Females of large species of Amblyomma engorge to a weight of 5 g and lay 20,000 eggs. The female dies after this single egg-laying. The male takes repeated small meals of blood and attempts to mate repeatedly whilst on the same host. Feeding times for larvae last 4–7 days, nymphs for 5–10 days, and adults for 8 to 20 days. The time spent molting and questing off the host can occupy the remainder of 6 to 18 months for a single tick to complete its lifecycle. The lifecycle timing is often expanded by diapause (delayed or inactivated development or activity) in adaptation to seasonal variation of moisture and heat. Ticks are highly adapted for long-term survival off the host without feeding and can extract moisture directly from humid air. However, survival is greatly reduced by excess heat, dryness, and lack of suitable hosts to which to attach. Survival on the host is also greatly reduced by grooming and by hypersensitive immune reactions in the skin against the feeding of the ticks.[ citation needed ]

Hosts

The lone star tick is an aggressive, generalist feeder; it actively pursues blood meals and is not specific about the species of host upon which it feeds. [4] As already mentioned, A. americanum requires a separate animal or human host to complete each stage of its life cycle. [6] The lifecycle begins when the blood-engorged adult female tick drops from her host, depositing around 5,000 eggs a few days later, once she has reached a safe and suitable location, such as in mulch or leaf litter. [4] After an incubation period, larvae hatch from their eggs and undergo a quiescent (resting) period; this is followed by the pursuit of a host via questing. [4] After feeding for one to three days, the blood-engorged larva dislodges from its host to digest its blood meal and molt into a nymph. The nymph follows this same pattern, attaching to a new host via questing and dropping from the host after its blood meal to molt into an adult tick. The female adult tick dies shortly after depositing her eggs. [4]

Larval lone star ticks have been found attached to birds and small mammals, and nymphal ticks have been found on these two groups, as well as on small rodents. [4] Adult lone star ticks usually feed on medium and large mammals, [6] and are very frequently found on white-tailed deer. [2] Lone star ticks also feed on humans at any stage of development. [2]

Vector

Like all ticks, it can be a vector of diseases including human monocytotropic ehrlichiosis ( Ehrlichia chaffeensis ), canine and human granulocytic ehrlichiosis ( Ehrlichia ewingii ), tularemia ( Francisella tularensis ), and southern tick-associated rash illness (STARI, possibly caused by the spirochete Borrelia lonestari ). [12] STARI exhibits a rash similar to that caused by Lyme disease, but is generally considered to be less severe.[ citation needed ]

Though the primary bacterium responsible for Lyme disease, Borrelia burgdorferi , has occasionally been isolated from lone star ticks, numerous vector competency tests have demonstrated that this tick is extremely unlikely to be capable of transmitting Lyme disease. Some evidence indicates A. americanum saliva inactivates B. burgdorferi more quickly than the saliva of Ixodes scapularis . [13] Recently the bacteria Borrelia andersonii and Borrelia americana have been linked to A. americanum. [14] [15]

In 2013, in response to two cases of severe febrile illness occurring in two farmers in northwestern Missouri, researchers determined the lone star tick can transmit the heartland virus. [16] Six more cases were identified in 2012–2013 in Missouri and Tennessee. [17]

Meat allergy

The bite of the lone star tick can cause a person to develop alpha-gal meat allergy, a delayed response to nonprimate mammalian meat and meat products. [18] [19] The allergy manifests as anaphylaxis —a life-threatening allergic reaction characterized by constriction of airways and a drop in blood pressure. [18] This response is triggered by an IgE antibody to the mammalian oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). [20] A study published in 2019 discovered alpha-gal in the saliva of the lone star tick. [21] The researcher has recently established the role of the tick Amblyomma americanum, widely distributed across the USA, in relation to tick bites using an alpha-gal knockout mouse model [22] As well as occurring in non-primate mammals, alpha-gal is also found in cat dander and in the drug cetuximab. [23] [20] Allergic reactions to alpha-gal usually occur 3–6 hours after consuming red meat, unlike allergic reactions to other foods, whose onset following consumption is more or less immediate, making it more difficult to identify what caused the reaction. [18] Skin tests with standard meat test solutions are unreliable when testing for alpha-gal allergy, whereas skin tests with raw meat and/or pork kidney are more sensitive. Specific tests for determination of IgE to alpha-gal are available. [24]

See also

Related Research Articles

<span class="mw-page-title-main">Tick</span> Order of arachnids in the arthropod phylum

Ticks are parasitic arachnids of the order Ixodida. They are part of the mite superorder Parasitiformes. Adult ticks are approximately 3 to 5 mm in length depending on age, sex, species, and "fullness". Ticks are external parasites, living by feeding on the blood of mammals, birds, and sometimes reptiles and amphibians. The timing of the origin of ticks is uncertain, though the oldest known tick fossils are from the Cretaceous period, around 100 million years old. Ticks are widely distributed around the world, especially in warm, humid climates.

<span class="mw-page-title-main">Ixodidae</span> Family of ticks

The Ixodidae are the family of hard ticks or scale ticks, one of the three families of ticks, consisting of over 700 species. They are known as 'hard ticks' because they have a scutum or hard shield, which the other major family of ticks, the 'soft ticks' (Argasidae), lack. They are ectoparasites of a wide range of host species, and some are vectors of pathogens that can cause human disease.

<span class="mw-page-title-main">Lyme disease</span> Infectious disease caused by Borrelia bacteria, spread by ticks

Lyme disease, also known as Lyme borreliosis, is a tick-borne disease caused by species of Borrelia bacteria, transmitted by blood-feeding ticks in the genus Ixodes. The most common sign of infection is an expanding red rash, known as erythema migrans (EM), which appears at the site of the tick bite about a week afterwards. The rash is typically neither itchy nor painful. Approximately 70–80% of infected people develop a rash. Early diagnosis can be difficult. Other early symptoms may include fever, headaches and tiredness. If untreated, symptoms may include loss of the ability to move one or both sides of the face, joint pains, severe headaches with neck stiffness or heart palpitations. Months to years later, repeated episodes of joint pain and swelling may occur. Occasionally, shooting pains or tingling in the arms and legs may develop.

Tick-borne diseases, which afflict humans and other animals, are caused by infectious agents transmitted by tick bites. They are caused by infection with a variety of pathogens, including rickettsia and other types of bacteria, viruses, and protozoa. The economic impact of tick-borne diseases is considered to be substantial in humans, and tick-borne diseases are estimated to affect ~80 % of cattle worldwide. Most of these pathogens require passage through vertebrate hosts as part of their life cycle. Tick-borne infections in humans, farm animals, and companion animals are primarily associated with wildlife animal reservoirs. Many tick-borne infections in humans involve a complex cycle between wildlife animal reservoirs and tick vectors. The survival and transmission of these tick-borne viruses are closely linked to their interactions with tick vectors and host cells. These viruses are classified into different families, including Asfarviridae, Reoviridae, Rhabdoviridae, Orthomyxoviridae, Bunyaviridae, and Flaviviridae.

<i>Ixodes holocyclus</i> Species of tick

Ixodes holocyclus, commonly known as the Australian paralysis tick, is one of about 75 species in the Australian tick fauna and is considered the most medically important. It can cause paralysis by injecting neurotoxins into its host. It is usually found in a 20-kilometre wide band following the eastern coastline of Australia. Within that range, Ixodes holocyclus is the tick most frequently encountered by humans and their pets. Because the same area includes Australia's most densely populated regions, bites on people, pets and livestock are relatively common.

<span class="mw-page-title-main">Erythema migrans</span> A rash in several vector-borne diseases

Erythema migrans or erythema chronicum migrans is an expanding rash often seen in the early stage of Lyme disease, and can also be caused by southern tick-associated rash illness (STARI). It can appear anywhere from one day to one month after a tick bite. This rash does not represent an allergic reaction to the bite, but rather an actual skin infection of one of the Lyme bacteria species from the genus Borrelia. The rash's name comes from Neo-Latin for "migrating redness."

<i>Dermacentor variabilis</i> Species of tick

Dermacentor variabilis, also known as the American dog tick or wood tick, is a species of tick that is known to carry bacteria responsible for several diseases in humans, including Rocky Mountain spotted fever and tularemia. It is one of the best-known hard ticks. Diseases are spread when it sucks blood from the host. It may take several days for the host to experience symptoms.

<i>Ixodes scapularis</i> Species of tick

Ixodes scapularis is commonly known as the deer tick or black-legged tick, and in some parts of the US as the bear tick. It was also named Ixodes dammini until it was shown to be the same species in 1993. It is a hard-bodied tick found in the eastern and northern Midwest of the United States as well as in southeastern Canada. It is a vector for several diseases of animals, including humans and is known as the deer tick owing to its habit of parasitizing the white-tailed deer. It is also known to parasitize mice, lizards, migratory birds, etc. especially while the tick is in the larval or nymphal stage.

<i>Ixodes ricinus</i> Species of tick

Ixodes ricinus, the castor bean tick, is a chiefly European species of hard-bodied tick. It may reach a length of 11 mm (0.43 in) when engorged with a blood meal, and can transmit both bacterial and viral pathogens such as the causative agents of Lyme disease and tick-borne encephalitis.

<span class="mw-page-title-main">Southern tick-associated rash illness</span> Medical condition

Southern tick-associated rash illness (STARI) is an emerging infectious disease related to Lyme disease that occurs in southeastern and south-central United States. It is spread by tick bites and it was hypothesized that the illness was caused by the bacteria Borrelia lonestari. However, there is insufficient evidence to declare this Borrelia strain as a causative agent.

Ehrlichia chaffeensis is an obligate intracellular, Gram-negative species of Rickettsiales bacteria. It is a zoonotic pathogen transmitted to humans by the lone star tick. It is the causative agent of human monocytic ehrlichiosis.

<span class="mw-page-title-main">Human monocytotropic ehrlichiosis</span> Medical condition

Human monocytotropic ehrlichiosis is a form of ehrlichiosis associated with Ehrlichia chaffeensis. This bacterium is an obligate intracellular pathogen affecting monocytes and macrophages.

<i>Rhipicephalus sanguineus</i> Species of species of tick found worldwide

Rhipicephalus sanguineus, commonly called the brown dog tick, kennel tick, or pantropical dog tick, is a species of tick found worldwide, but more commonly in warmer climates. This species is unusual among ticks in that its entire lifecycle can be completed indoors. The brown dog tick is easily recognized by its reddish-brown color, elongated body shape, and hexagonal basis capituli. Adults are 2.28 to 3.18 mm in length and 1.11 to 1.68 mm in width. They do not have ornamentation on their backs.

Ehrlichiosis ewingii infection is an infectious disease caused by an intracellular bacteria, Ehrlichia ewingii. The infection is transmitted to humans by the tick, Amblyomma americanum. This tick can also transmit Ehrlichia chaffeensis, the bacteria that causes human monocytic ehrlichiosis (HME).

<i>Ixodes pacificus</i> Species of arachnid

Ixodes pacificus, the western black-legged tick, is a species of tick found on the western coast of North America. I. pacificus is a member of the family Ixodidae. It is the principal vector of Lyme disease in that region. I. pacificus larvae and nymphs typically feeds on lizards and small mammals, while adults typically feed on deer. It is an ectoparasite that attaches itself to the outside of its host and feeds on the host's blood. It can have a heteroxenous lifestyle or monoxenous life cycle depending on how many hosts it feeds on in each cycle. I. pacificus has a four-stage life cycle that takes around 3 years to complete. These stages include egg, larva, nymph, and adult. They prefer dense woodland habitats or areas of brush and tall grass.

<i>Ornithodoros moubata</i> Species of tick

Ornithodoros moubata, commonly known as the African hut tampan or the eyeless tampan, is a species of tick in the family Argasidae. It is an ectoparasite and vector of relapsing fever in humans, and African swine fever in pigs.

<span class="mw-page-title-main">Ticks of domestic animals</span>

Ticks of domestic animals directly cause poor health and loss of production to their hosts. Ticks also transmit numerous kinds of viruses, bacteria, and protozoa between domestic animals. These microbes cause diseases which can be severely debilitating or fatal to domestic animals, and may also affect humans. Ticks are especially important to domestic animals in tropical and subtropical countries, where the warm climate enables many species to flourish. Also, the large populations of wild animals in warm countries provide a reservoir of ticks and infective microbes that spread to domestic animals. Farmers of livestock animals use many methods to control ticks, and related treatments are used to reduce infestation of companion animals.

<span class="mw-page-title-main">Galactose-α-1,3-galactose</span> Chemical compound

Galactose-α-1,3-galactose, commonly known as alpha gal and the Galili antigen, is a carbohydrate found in most mammalian cell membranes. It is not found in catarrhines, including humans, who have lost the GGTA1 gene. Their immune systems recognize it as a foreign body and produce xenoreactive immunoglobulin M (IgM) antibodies, leading to organ rejection after transplantation.

Alpha-gal syndrome (AGS), also known as alpha-gal allergy or mammalian meat allergy (MMA), is a type of acquired allergy characterized by a delayed onset of symptoms after ingesting mammalian meat. The condition results from past exposure to certain tick bites and was first reported in 2002. Symptoms of the allergy vary greatly between individuals and include rash, hives, nausea or vomiting, difficulty breathing, drop in blood pressure, dizziness or faintness, diarrhea, severe stomach pain, and possible anaphylaxis.

<i>Ixodes angustus</i> Species of tick

Ixodes angustus is a species of parasitic tick, whose range encompasses the majority of Canada and the United States, along with parts of northern Mexico. I. angustus is a member of the Ixodidae (hard-bodied) family of ticks. It is most abundant in cool, moist biomes such as riparian, boreal or montane zones. I. angustus is a host generalist and has been discovered feeding on more than 90 different host species, including humans and domestic dogs. I. angustus has been identified as a potential vector for Lyme disease but is not considered a principal vector due to the relative rarity with which it feeds on humans.

References

  1. ↑ "Amblyomma americanum". The Encyclopedia of Life .
  2. 1 2 3 Fisher, Emily J.; Mo, Jun; Lucky, Anne W. (2006-04-01). "Multiple Pruritic Papules From Lone Star Tick Larvae Bites". Archives of Dermatology. 142 (4): 491–4. doi: 10.1001/archderm.142.4.491 . ISSN   0003-987X. PMID   16618870.
  3. 1 2 "Geographic distribution of ticks that bite humans". cdc.gov. enters for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Vector-Borne Diseases (DVBD). June 1, 2015. Retrieved October 30, 2016.
  4. 1 2 3 4 5 6 7 8 9 "lone star tick - Amblyomma americanum (Linnaeus)". entnemdept.ufl.edu. Retrieved 2016-12-12.
  5. ↑ "Ehrlichiosis | CDC". www.cdc.gov. 2018-09-25. Retrieved 2016-12-12.
  6. 1 2 3 "Amblyomma americanum (Lone star tick)". Wisconsin Ticks and Tick-borne Diseases. 2012-05-30. Retrieved 2016-12-12.
  7. 1 2 3 "CVBD - Lone Star Tick - Amblyomma americanum". www.cvbd.org. Retrieved 2016-12-12.
  8. 1 2 Soneshine, Daniel E. (1992). Biology of Ticks Volume I. Oxford University Press. ISBN   978-0195059106.
  9. ↑ Resources, University of California Agriculture and Natural. "Tick Biology". entomology.ucdavis.edu. Retrieved 2016-12-12.
  10. ↑ "3 tick that causes red meat allergy found in Waterloo region over last 3 years". CBC News . 2019-07-05.
  11. ↑ Holderman, Christopher J., and Phillip E. Kaufman. Lone Star Tick Amblyomma Americanum (Linnaeus): (Acari: Ixodidae). Entomology and Nematology Department, UF/IFAS Extension. The Institute of Food and Agricultural Sciences (IFAS), Jan. 2014. Web.
  12. ↑ Edwin J. Masters; Chelsea N. Grigery; Reid W. Masters (June 2008). "STARI, or Masters disease: lone star tick-vectored Lyme-like illness". Infectious Disease Clinics of North America . 22 (2): 361–376, viii. doi:10.1016/j.idc.2007.12.010. PMID   18452807.
  13. ↑ K. E. Ledin; N. S. Zeidner; J. M. C. Ribeiro; B. J. Biggerstaff; M. C. Dolan; G. Dietrich; L. VredEvoe; J. Piesman (March 2005). "Borreliacidal activity of saliva of the tick Amblyomma americanum". Medical and Veterinary Entomology . 19 (1): 90–95. doi:10.1111/j.0269-283X.2005.00546.x. PMID   15752182. S2CID   270178.
  14. ↑ Kerry L. Clark; Brian Leydet; Shirley Hartman (2013). "Lyme Borreliosis in Human Patients in Florida and Georgia, USA". Int J Med Sci. 10 (7): 915–931. doi:10.7150/ijms.6273. ISSN   1449-1907. PMC   3675506 . PMID   23781138.
  15. ↑ Piesman J, Sinsky RJ., Ability of Ixodes scapularis, Dermacentor variabilis, and Amblyomma americanum (Acari: Ixodidae) to acquire, maintain, and transmit Lyme disease spirochetes (Borrelia burgdorferi); J Med Entomol. 1988 September; 25(5):336-9.
  16. ↑ Harry M. Savage; Marvin S. Godsey Jr.; Amy Lambert; Nickolas A. Panella; Kristen L. Burkhalter; Jessica R. Harmon; R. Ryan Lash; David C. Ashley; William L. Nicholson (22 July 2013). "First Detection of Heartland Virus (Bunyaviridae: Phlebovirus) from Field Collected Arthropods". Am J Trop Med Hyg. 89 (3): 445–452. doi:10.4269/ajtmh.13-0209. PMC   3771279 . PMID   23878186.
  17. ↑ "CDC Reports More Cases of Heartland Virus Disease". CDC. January 2016. Retrieved 25 May 2016.
  18. 1 2 3 "NIAID scientists link cases of unexplained anaphylaxis to red meat allergy". National Institutes of Health (NIH). 2017-11-28. Retrieved 2018-05-09.
  19. ↑ Commins, Scott P.; James, Hayley R.; Kelly, Libby A.; Pochan, Shawna L.; Workman, Lisa J.; Perzanowski, Matthew S.; Kocan, Katherine M.; Fahy, John V.; Nganga, Lucy W.; Ronmark, Eva; Cooper, Philip J.; Platts-Mills, Thomas A.E. (May 2011). "The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose". The Journal of Allergy and Clinical Immunology. 127 (5): 1286–1293. doi:10.1016/j.jaci.2011.02.019. PMC   3085643 . PMID   21453959 . Retrieved 20 May 2014.
  20. 1 2 Steinke, John W; Platts-Mills, Thomas AE; Commins, Scott P (2015). "The alpha gal story: Lessons learned from connecting the dots". The Journal of Allergy and Clinical Immunology. 135 (3): 589–597. doi:10.1016/j.jaci.2014.12.1947. ISSN   0091-6749. PMC   4600073 . PMID   25747720.
  21. ↑ Crispell, Gary; Commins, Scott P.; Archer-Hartman, Stephanie A.; Choudhary, Shailesh; Dharmarajan, Guha; Azadi, Parastoo; Karim, Shahid (17 May 2019). "Discovery of Alpha-Gal-Containing Antigens in North American Tick Species Believed to Induce Red Meat Allergy". Frontiers in Immunology. 10: 1056. doi: 10.3389/fimmu.2019.01056 . PMC   6533943 . PMID   31156631.
  22. ↑ Sharma, Surendra Raj; Choudhary, Shailesh K.; Vorobiov, Julia; Commins, Scott P.; Karim, Shahid (2023). "Tick bite-induced alpha-gal syndrome and immunologic responses in an alpha-gal deficient murine model". Frontiers in Immunology. 14: 1336883. doi: 10.3389/fimmu.2023.1336883 . ISSN   1664-3224. PMC   10882631 . PMID   38390396.
  23. ↑ Gonzalez-Quintela, A.; Dam Laursen, A. S.; Vidal, C.; Skaaby, T.; Gude, F.; Linneberg, A. (August 2014). "IgE antibodies to alpha-gal in the general adult population: relationship with tick bites, atopy, and cat ownership". Clinical & Experimental Allergy. 44 (8): 1061–1068. doi:10.1111/cea.12326. ISSN   1365-2222. PMID   24750173. S2CID   388053.
  24. ↑ Bircher, Andreas J.; Hofmeier, Kathrin Scherer; Link, Susanne; Heijnen, Ingmar (2017-02-01). "Food allergy to the carbohydrate galactose-alpha-1,3-galactose (alpha-gal): four case reports and a review". European Journal of Dermatology. 27 (1): 3–9. doi:10.1684/ejd.2016.2908. ISSN   1952-4013. PMID   27873733. S2CID   2400078.
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