Names | |
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IUPAC name 1-N',4-N'-bis[N'-(4-chlorophenyl)carbamimidoyl]piperazine-1,4-dicarboximidamide | |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.024.623 |
PubChem CID | |
UNII | |
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Properties | |
C20H24Cl2N10 | |
Molar mass | 475.37756 |
Pharmacology | |
S01AX16 ( WHO ) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Picloxydine (trade name Vitabact [1] ) is a bisbiguanide antiseptic used in eye drops. It is structurally similar to chlorhexidine.
Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may occur. The affected eye may have increased tears or be "stuck shut" in the morning. Swelling of the white part of the eye may also occur. Itching is more common in cases due to allergies. Conjunctivitis can affect one or both eyes.
The evil eye is a superstitious curse or legend, believed to be cast by a malevolent glare, usually given to a person when one is unaware. It dates back at least to Greek classical antiquity, 6th century BCE where it appeared on Chalcidian drinking vessels, known as 'eye cups', as a type of apotropaic magic. Many cultures believe that receiving the evil eye will cause misfortune or injury, while others believe it to be a kind of supernatural force that casts or reflects a malevolent gaze back-upon those who wish harm upon others. Talismans or amulets created to protect against the evil eye are also frequently called "evil eyes". Older iterations of the symbol were often made of ceramic or clay, however, following the production of glass beads in the Mediterranean region in approximately 1500 BCE, evil eye beads were popularised with the Phoenicians, Persians, Greeks, Romans and Ottomans. Blue was likely used as it was relatively easy to create, however, modern evil eyes can be a range of colors.
Presbyopia is physiological insufficiency of accommodation associated with the aging of the eye that results in progressively worsening ability to focus clearly on close objects. Symptoms include difficulty reading small print, having to hold reading material farther away, headaches, and eyestrain. Different people will have different degrees of problems. Other types of refractive errors may exist at the same time as presbyopia.
Cyclopentolate is a muscarinic antagonist. It is commonly used as an eye drop during pediatric eye examinations to dilate the eye (mydriatic) and prevent the eye from focusing/accommodating (cycloplegic). Cyclopentolate or atropine can also be administered to reverse muscarinic and central nervous system effects of indirect cholinomimetic (anti-AChase) administration.
Tetryzoline is a drug used in some over-the-counter eye drops and nasal sprays.
Allergic conjunctivitis (AC) is inflammation of the conjunctiva due to allergy. Although allergens differ among patients, the most common cause is hay fever. Symptoms consist of redness, edema (swelling) of the conjunctiva, itching, and increased lacrimation. If this is combined with rhinitis, the condition is termed allergic rhinoconjunctivitis (ARC).
Eye drops or eyedrops are saline-containing drops used as an ocular route to administer. Depending on the condition being treated, they may contain steroids, antihistamines, sympathomimetics, beta receptor blockers, parasympathomimetics, parasympatholytics, prostaglandins, nonsteroidal anti-inflammatory drugs (NSAIDs), antibiotics, antifungals, or topical anesthetics. Eye drops sometimes do not have medications in them and are only lubricating and tear-replacing solutions.
Artificial tears are lubricating eye drops used to relieve dryness and irritation of the ocular surface. Dry eye syndrome is a common ocular surface disorder and is characterized by disruption of the tear film and increased inflammation.
Electrooculography (EOG) is a technique for measuring the corneo-retinal standing potential that exists between the front and the back of the human eye. The resulting signal is called the electrooculogram. Primary applications are in ophthalmological diagnosis and in recording eye movements. Unlike the electroretinogram, the EOG does not measure response to individual visual stimuli.
9 Andromedae, abbreviated 9 And by convention, is a variable binary star system in the northern constellation Andromeda. 9 Andromedae is the Flamsteed designation, while it bears the variable star designation AN Andromedae, or AN And. The maximum apparent visual magnitude of the system is 5.98, which places it near the lower limit of visibility to the human eye. Based upon an annual parallax shift of 7.1 mas, it is located 460 light years from the Earth.
Scleritis is a serious inflammatory disease that affects the white outer coating of the eye, known as the sclera. The disease is often contracted through association with other diseases of the body, such as granulomatosis with polyangiitis or rheumatoid arthritis. There are three types of scleritis: diffuse scleritis, nodular scleritis, and necrotizing scleritis. Scleritis may be the first symptom of onset of connective tissue disease.
Neonatal conjunctivitis is a form of conjunctivitis which affects newborn babies following birth. It is typically due to neonatal bacterial infection, although can also be non-infectious. Infectious neonatal conjunctivitis is typically contracted during vaginal delivery from exposure to bacteria from the birth canal, most commonly Neisseria gonorrhoeae or Chlamydia trachomatis.
Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye. Specifically it is used to help examine the back of the eye. It is applied as eye drops. Effects occur within 40 minutes and last for up to a day.
Azelastine, sold under the brand name Optivar among others, is a medication primarily used as a nasal spray to treat allergic rhinitis and as eye drops for allergic conjunctivitis. Other uses may include asthma and skin rashes for which it is taken by mouth. Onset of effects is within minutes when used in the eyes and within an hour when used in the nose. Effects last for up to 12 hours.
Oncomodulin is a parvalbumin-family calcium-binding protein expressed and secreted by macrophages.
IU Aurigae is a triple star system in the constellation Auriga, consisting of an eclipsing binary pair orbiting a third component with a period of 335 years. This system is too faint to be viewed with the naked eye, having a peak apparent visual magnitude of 8.19. The eclipsing pair form a Beta Lyrae-type semidetached binary of two Bp stars with a period of 1.81147435 days. During the primary eclipse, the visual magnitude of the system drops to 8.89, while for the secondary it decreases to 8.74. The third component is a massive object with 17–18 M☉, and may actually be a binary – which would make this a quadruple star system.
The Barque of Dante, also Dante and Virgil in Hell, is the first major painting by the French artist Eugène Delacroix, and is a work signalling the shift in the character of narrative painting, from Neo-Classicism towards Romanticism. The painting loosely depicts events narrated in canto eight of Dante's Inferno; a leaden, smoky mist and the blazing City of the Dead form the backdrop against which the poet Dante fearfully endures his crossing of the River Styx. As his barque ploughs through waters heaving with tormented souls, Dante is steadied by Virgil, the learned poet of Classical antiquity.
Lifitegrast, sold under the brand name Xiidra, is a medication for the treatment of signs and symptoms of dry eye, a syndrome called keratoconjunctivitis sicca. Lifitegrast reduces inflammation by inhibiting inflammatory cell binding. It is often used in conjunction with ciclosporin for dry eye treatment including meibomian gland dysfunction and inflammatory dry eye.
Ophthalmic drug administration is the administration of a drug to the eyes, most typically as an eye drop formulation. Topical formulations are used to combat a multitude of diseased states of the eye. These states may include bacterial infections, eye injury, glaucoma, and dry eye. However, there are many challenges associated with topical delivery of drugs to the cornea of the eye.
LQ Andromedae is a variable star in the constellation Andromeda. Its maximum apparent visual magnitude is 6.5, placing it at the limit of the visibility to the naked eye. The brightness, however, drops down to 6.66 with a periodic cycle of roughly 7.44 hours.