Sir Alexander Fleming was a Scottish physician and microbiologist, best known for discovering the world's first broadly effective antibiotic substance, which he named penicillin. His discovery in 1928 of what was later named benzylpenicillin from the mould Penicillium rubens has been described as the "single greatest victory ever achieved over disease". For this discovery, he shared the Nobel Prize in Physiology or Medicine in 1945 with Howard Florey and Ernst Chain.
Penicillins are a group of β-lactam antibiotics originally obtained from Penicillium moulds, principally P. chrysogenum and P. rubens. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G and penicillin V. Penicillins were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today for various bacterial infections, though many types of bacteria have developed resistance following extensive use.
An invention is a unique or novel device, method, composition, idea or process. An invention may be an improvement upon a machine, product, or process for increasing efficiency or lowering cost. It may also be an entirely new concept. If an idea is unique enough either as a stand-alone invention or as a significant improvement over the work of others, it can be patented. A patent, if granted, gives the inventor a proprietary interest in the patent over a specific period of time, which can be licensed for financial gain.
Discovery is the act of detecting something new, or something previously unrecognized as meaningful. In sciences and academic disciplines, discovery is the observation of new phenomena, new actions, or new events and involves providing new reasoning to explain the knowledge gathered through such observations, using knowledge previously acquired through abstract thought and from everyday experiences. Some discoveries represent a radical breakthrough in knowledge or technology. Others are based on earlier discoveries, collaborations or ideas. In such cases, the process of discovery requires at least the awareness that an existing concept or method could be modified or transformed. New discoveries are made using various senses, and are usually added to pre-existing knowledge. Questioning plays a key role in discovery; discoveries are often made due to questions. Some discoveries lead to the invention of objects, processes, or techniques.
Science studies is an interdisciplinary research area that seeks to situate scientific expertise in broad social, historical, and philosophical contexts. It uses various methods to analyze the production, representation and reception of scientific knowledge and its epistemic and semiotic role.
Norman George Heatley OBE was an English biologist and biochemist. He was a member of the team of Oxford University scientists who developed penicillin. Heatley developed the back-extraction technique for efficiently purifying penicillin in bulk.
George de Mestral was a Swiss electrical engineer who invented the hook and loop fastener which he named Velcro.
Grounded theory is a systematic methodology that has been largely applied to qualitative research conducted by social scientists. The methodology involves the construction of hypotheses and theories through the collecting and analysis of data. Grounded theory involves the application of inductive reasoning. The methodology contrasts with the hypothetico-deductive model used in traditional scientific research.
The history of penicillin follows observations and discoveries of evidence of antibiotic activity of the mould Penicillium that led to the development of penicillins that became the first widely used antibiotics. Following the production of a relatively pure compound in 1942, penicillin was the first naturally-derived antibiotic.
Patsy O’Connell Sherman was an American chemist and co-inventor of Scotchgard, a 3M brand of products, a stain repellent and durable water repellent.
Clodomiro Picado Twight, also known as "Clorito Picado", was a Costa Rican scientist who was internationally recognized for his pioneering research on snake venom and the development of various antivenins. His work on molds was a precursor to the formal discovery of penicillin and resulted in compounds which he used to treat patients at least one year before the re-discovery of penicillin by Alexander Fleming. He wrote over 115 works, mainly books and monographs.
The concept of multiple discovery is the hypothesis that most scientific discoveries and inventions are made independently and more or less simultaneously by multiple scientists and inventors. The concept of multiple discovery opposes a traditional view—the "heroic theory" of invention and discovery. Multiple discovery is analogous to convergent evolution in biological evolution.
Velcro IP Holdings LLC, doing business as Velcro Companies and commonly referred to as Velcro, is a British privately held company, founded by Swiss electrical engineer George de Mestral in the 1950s. It is the original manufacturer of hook-and-loop fasteners, which de Mestral invented.
The discovery of penicillin was one of the most important scientific discoveries in the history of medicine. Ancient societies used moulds to treat infections and in the following centuries many people observed the inhibition of bacterial growth by moulds. While working at St Mary's Hospital in London in 1928, Scottish physician Alexander Fleming was the first to experimentally demonstrate that a Penicillium mould secretes an antibacterial substance, which he named "penicillin". The mould was found to be a variant of Penicillium notatum, a contaminant of a bacterial culture in his laboratory. The work on penicillin at St Mary's ended in 1929.
Science and technology in the United Kingdom has a long history, producing many important figures and developments in the field. Major theorists from the United Kingdom of Great Britain and Northern Ireland include Isaac Newton whose laws of motion and illumination of gravity have been seen as a keystone of modern science and Charles Darwin whose theory of evolution by natural selection was fundamental to the development of modern biology. Major scientific discoveries include hydrogen by Henry Cavendish, penicillin by Alexander Fleming, and the structure of DNA, by Francis Crick and others. Major engineering projects and applications pursued by people from the United Kingdom include the steam locomotive developed by Richard Trevithick and Andrew Vivian, the jet engine by Frank Whittle and the World Wide Web by Tim Berners-Lee. The United Kingdom continues to play a major role in the development of science and technology and major technological sectors include the aerospace, motor and pharmaceutical industries.
The role of chance, or "luck", in science comprises all ways in which unexpected discoveries are made.
Logology is the study of all things related to science and its practitioners—philosophical, biological, psychological, societal, historical, political, institutional, financial. The term "logology" is back-formed from the suffix "-logy", as in "geology", "anthropology", etc., in the sense of the "study of science". The word "logology" provides grammatical variants not available with the earlier terms "science of science" and "sociology of science", such as "logologist", "logologize", "logological", and "logologically". The emerging field of metascience is a subfield of logology.
To be blown off course in the sailing ship era meant be to diverted by unexpected winds, getting lost possibly to shipwreck or to a new destination. In the ancient world, this was especially a great danger before the maturation of the Maritime Silk Road in the Early Middle Ages, finding expression in the writing of Cosmas Indicopleustes. Even in later eras, the ship could attempt to limit its divergence by tacking or heaving to, but it was often difficult to keep track by mere celestial navigation before the invention of the marine chronometer in the late 18th century.
Serendipity: Accidental Discoveries in Science is a 1989 popular science book by the chemist Royston M. Roberts. It received positive and mixed reviews; critics found it informative and entertaining, though some indicated that it contained errors.
