Organometallic chemistry is the study of organometallic compounds, chemical compounds containing at least one chemical bond between a carbon atom of an organic molecule and a metal, including alkali, alkaline earth, and transition metals, and sometimes broadened to include metalloids like boron, silicon, and selenium, as well. Aside from bonds to organyl fragments or molecules, bonds to 'inorganic' carbon, like carbon monoxide, cyanide, or carbide, are generally considered to be organometallic as well. Some related compounds such as transition metal hydrides and metal phosphine complexes are often included in discussions of organometallic compounds, though strictly speaking, they are not necessarily organometallic. The related but distinct term "metalorganic compound" refers to metal-containing compounds lacking direct metal-carbon bonds but which contain organic ligands. Metal β-diketonates, alkoxides, dialkylamides, and metal phosphine complexes are representative members of this class. The field of organometallic chemistry combines aspects of traditional inorganic and organic chemistry.
Gabor A. Somorjai is a professor of chemistry at the University of California, Berkeley, and is a leading researcher in the field of surface chemistry and catalysis, especially the catalytic effects of metal surfaces on gas-phase reactions. For his contributions to the field, Somorjai won the Wolf Prize in Chemistry in 1998, the Linus Pauling Award in 2000, the National Medal of Science in 2002, the Priestley Medal in 2008, the 2010 BBVA Foundation Frontiers of Knowledge Award in Basic Science and the NAS Award in Chemical Sciences in 2013. In April 2015, Somorjai was awarded the American Chemical Society's William H. Nichols Medal.
Palladium(II) acetate is a chemical compound of palladium described by the formula [Pd(O2CCH3)2]n, abbreviated [Pd(OAc)2]n. It is more reactive than the analogous platinum compound. Depending on the value of n, the compound is soluble in many organic solvents and is commonly used as a catalyst for organic reactions.
Tris(dibenzylideneacetone)dipalladium(0) or [Pd2(dba)3] is an organopalladium compound. The compound is a complex of palladium(0) with dibenzylideneacetone (dba). It is a dark-purple/brown solid, which is modestly soluble in organic solvents. Because the dba ligands are easily displaced, the complex is used as a homogeneous catalyst in organic synthesis.
In organic chemistry, the Buchwald–Hartwig amination is a chemical reaction for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed coupling reactions of amines with aryl halides. Although Pd-catalyzed C–N couplings were reported as early as 1983, Stephen L. Buchwald and John F. Hartwig have been credited, whose publications between 1994 and the late 2000s established the scope of the transformation. The reaction's synthetic utility stems primarily from the shortcomings of typical methods for the synthesis of aromatic C−N bonds, with most methods suffering from limited substrate scope and functional group tolerance. The development of the Buchwald–Hartwig reaction allowed for the facile synthesis of aryl amines, replacing to an extent harsher methods while significantly expanding the repertoire of possible C−N bond formations.
Julius Rebek Jr. is a Hungarian-American chemist and expert on molecular self-assembly.
Tobin Jay Marks is an inorganic chemistry Professor, the Vladimir N. Ipatieff Professor of Catalytic Chemistry, Professor of Material Science and Engineering, Professor of Chemical and Biological Engineering, and Professor of Applied Physics at Northwestern University in Evanston, Illinois. Among the themes of his research are synthetic organo-f-element and early-transition metal organometallic chemistry, polymer chemistry, materials chemistry, homogeneous and heterogeneous catalysis, molecule-based photonic materials, superconductivity, metal-organic chemical vapor deposition, and biological aspects of transition metal chemistry.
Pierre Braunstein is a French chemist. He was director of the Laboratoire de Chimie de Coordination of Strasbourg (France) and is a member of the French Academy of Science.
1,1′-Bis(diphenylphosphino)ferrocene, commonly abbreviated dppf, is an organophosphorus compound commonly used as a ligand in homogeneous catalysis. It contains a ferrocene moiety in its backbone, and is related to other bridged diphosphines such as 1,2-bis(diphenylphosphino)ethane (dppe).
Eric N. Jacobsen is the Sheldon Emery Professor of Chemistry and former chair of the department of chemistry and chemical biology at Harvard University. He is a prominent figure in the field of organic chemistry and is best known for the development of the Jacobsen epoxidation and other work in selective catalysis.
Bruce H. Lipshutz is an American chemist. He is a professor at the University of California, Santa Barbara.
Thomas C. Bruice was a professor of chemistry and biochemistry at University of California, Santa Barbara. He was elected to the National Academy of Sciences in 1974. He was a pioneering researcher in the area of chemical biology, and is one of the 50 most cited chemists.
A metal-phosphine complex is a coordination complex containing one or more phosphine ligands. Almost always, the phosphine is an organophosphine of the type R3P (R = alkyl, aryl). Metal phosphine complexes are useful in homogeneous catalysis. Prominent examples of metal phosphine complexes include Wilkinson's catalyst (Rh(PPh3)3Cl), Grubbs' catalyst, and tetrakis(triphenylphosphine)palladium(0).
A Josiphos ligand is a type of chiral diphosphine which has been modified to be substrate-specific; they are widely used for enantioselective synthesis. They are widely used in asymmetric catalysis.
John Perry Wolfe is an American chemist and a professor of chemistry at the University of Michigan. He is best known for palladium-catalyzed C-C and C-N bond formation reactions. He was also one of the key scientists in the development of Buchwald ligands, one of which is appropriately named "JohnPhos" after him. Wolfe has taught at the University of Michigan since 2002.
John F. Hartwig is an American organometallic chemist who holds the position of Henry Rapoport Professor of Chemistry at the University of California, Berkeley. His laboratory traditionally focuses on developing transition metal-catalyzed reactions. Hartwig is known for helping develop the Buchwald–Hartwig amination, a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed cross-coupling of amines with aryl halides.
Dialkylbiaryl phosphine ligands are phosphine ligands that are used in homogeneous catalysis. They have proved useful in Buchwald-Hartwig amination and etherification reactions as well as Negishi cross-coupling, Suzuki-Miyaura cross-coupling, and related reactions. In addition to these Pd-based processes, their use has also been extended to transformations catalyzed by nickel, gold, silver, copper, rhodium, and ruthenium, among other transition metals.
Christopher "Kit" Colin Cummins is an American chemist, currently the Henry Dreyfus Professor at the Massachusetts Institute of Technology. He has made contributions to the coordination chemistry of transition metal nitrides, phosphides, and carbides.
Xile Hu is a Swiss chemist specialized in catalysis. He is a professor in chemistry at EPFL and leads the Laboratory of Inorganic Synthesis and Catalysis at the School of Basic Sciences.
Jennifer Schomaker is an American chemist who is a professor at the University of Wisconsin–Madison. Her research considers the total synthesis of natural and unnatural products. She was selected as an American Chemical Society Arthur C. Cope Scholar Awardee in 2021.
