Elias James Corey is an American organic chemist. In 1990, he won the Nobel Prize in Chemistry "for his development of the theory and methodology of organic synthesis", specifically retrosynthetic analysis.
Organic synthesis is a branch of chemical synthesis concerned with the construction of organic compounds. Organic compounds are molecules consisting of combinations of covalently-linked hydrogen, carbon, oxygen, and nitrogen atoms. Within the general subject of organic synthesis, there are many different types of synthetic routes that can be completed including total synthesis, stereoselective synthesis, automated synthesis, and many more. Additionally, in understanding organic synthesis it is necessary to be familiar with the methodology, techniques, and applications of the subject.
Kyriacos Costa Nicolaou is a Cypriot-American chemist known for his research in the area of natural products total synthesis. He is currently Harry C. and Olga K. Wiess Professor of Chemistry at Rice University, having previously held academic positions at The Scripps Research Institute/UC San Diego and the University of Pennsylvania.
The Danishefsky Taxol total synthesis in organic chemistry is an important third Taxol synthesis published by the group of Samuel Danishefsky in 1996 two years after the first two efforts described in the Holton Taxol total synthesis and the Nicolaou Taxol total synthesis. Combined they provide a good insight in the application of organic chemistry in total synthesis.
Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew. Not only is the synthetic reproduction of the compound itself of great commercial and scientific importance, but it also opens the way to paclitaxel derivatives not found in nature but with greater potential.
Gilbert Stork was an organic chemist. For a quarter of a century he was the Eugene Higgins Professor of Chemistry Emeritus at Columbia University. He is known for making significant contributions to the total synthesis of natural products, including a lifelong fascination with the synthesis of quinine. In so doing he also made a number of contributions to mechanistic understanding of reactions, and performed pioneering work on enamine chemistry, leading to development of the Stork enamine alkylation. It is believed he was responsible for the first planned stereocontrolled synthesis as well as the first natural product to be synthesised with high stereoselectivity.
Eric N. Jacobsen is the Sheldon Emery Professor of Chemistry and former chair of the department of chemistry and chemical biology at Harvard University. He is a prominent figure in the field of organic chemistry and is best known for the development of the Jacobsen epoxidation and other work in selective catalysis.
Larry E. Overman is Distinguished Professor of Chemistry at the University of California, Irvine. He was born in Chicago in 1943. Overman obtained a B.A. degree from Earlham College in 1965, and he completed his Ph.D. in chemistry from the University of Wisconsin–Madison in 1969, under Howard Whitlock Jr. Professor Overman is a member of the United States National Academy of Sciences and the American Academy of Arts and Sciences. He was the recipient of the Arthur C. Cope Award in 2003, and he was awarded the Tetrahedron Prize for Creativity in Organic Chemistry for 2008.
Michael E. Jung is a Professor of Chemistry in the Department of Chemistry and Biochemistry at the University of California at Los Angeles.
James Lincoln Leighton is a Professor of Chemistry in the Department of Chemistry at Columbia University. He is known for his non-aldol approaches to polyketides.
John F. Hartwig is an American organometallic chemist who holds the position of Henry Rapoport Professor of Chemistry at the University of California, Berkeley. His laboratory traditionally focuses on developing transition metal-catalyzed reactions. Hartwig is known for helping develop the Buchwald–Hartwig amination, a chemical reaction used in organic chemistry for the synthesis of carbon–nitrogen bonds via the palladium-catalyzed cross-coupling of amines with aryl halides.
Stephen L. Buchwald is a U.S. chemist and Camille Dreyfus Professor of Chemistry at MIT. He is known for his involvement in the development of the Buchwald-Hartwig amination and the discovery of the dialkylbiaryl phosphine ligand family for promoting this reaction and related transformations. He was elected as a fellow of the American Academy of Arts and Sciences and as a member of the National Academy of Sciences in 2000 and 2008, respectively.
Dirk Trauner is an Austrian-American chemist.
Adusumilli Srikrishna (1955–2013) was an Indian organic chemist and a professor at the department of organic chemistry at the Indian Institute of Science. He was known for his researches on radical cyclisation and natural products synthesis. He was an elected fellow of the Indian National Science Academy, National Academy of Sciences, India and the Indian Academy of Sciences. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1997, for his contributions to chemical sciences.
Subramania Ranganathan (1934–2016), popularly known as Ranga, was an Indian bioorganic chemist and professor and head of the department of chemistry at the Indian Institute of Technology, Kanpur. He was known for his studies on synthetic and mechanistic organic chemistry and was an elected fellow Indian National Science Academy, National Academy of Sciences, India and the Indian Academy of Sciences The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards, in 1977, for his contributions to chemical sciences.
Paul AnthonyWender is an American chemist whose work is focused on organic chemistry, organometallic chemistry, synthesis, catalysis, chemical biology, imaging, drug delivery, and molecular therapeutics. He is currently the Francis W. Bergstrom Professor of Chemistry at Stanford University and is an Elected Fellow at the American Association for the Advancement of Science and the American Academy of Arts and Sciences.
Wendy B. Young is an advisor at Google Ventures and a former senior vice president of small molecule drug discovery at Genentech.
Rick L. Danheiser is an American organic chemist and is the Arthur C. Cope Professor of Chemistry at the Massachusetts Institute of Technology and chair of the MIT faculty. His research involves the invention of new methods for the synthesis of complex organic compounds. Danheiser is known for the Danheiser annulation and Danheiser benzannulation reactions.
Steven D'Wayne Townsend is a professor of organic chemistry at Vanderbilt University. He investigates the chemistry of human breast milk. In 2019 Townsend was selected as one of Chemical & Engineering News Talented 12.
Teruaki Mukaiyama was a Japanese organic chemist. One of the most prolific chemists of the 20th century in the field of organic synthesis, Mukaiyama helped establish the field of organic chemistry in Japan after World War II.
