U.S. Route 411 (US 411) is an alternate parallel-highway associated with US 11. It extends for about 309.7 miles (498.4 km) from US 78 in Leeds, Alabama, to US 25W/US 70 in Newport, Tennessee. US 411 travels through northeastern Alabama, northwestern Georgia, and southeastern Tennessee. It is signed north-south, as with most highways that have odd numbers, but the route runs primarily in a northeast-southwest direction, and covers a more east-west mileage than it does north-south. Notable towns and cities along its route include Gadsden, Alabama; Rome, Georgia; Cartersville, Georgia; Maryville, Tennessee; Sevierville, Tennessee, and Newport, Tennessee.
State Route 168 is a state highway in Knox County, Tennessee, that is 18.1 miles long. Its western terminus is with US 129/SR 115, and its eastern terminus is with US 11/US 11E/US 11W/US 70/SR 1.
The Great Smoky Mountains Parkway is a highway that travels 23.4 miles (37.7 km) between the Great Smoky Mountains National Park and Interstate 40 (I-40) in Kodak, Tennessee, in East Tennessee. It serves as the main thoroughfare for Gatlinburg, Pigeon Forge, and Sevierville, and includes a 4.3-mile (6.9 km) spur of the Foothills Parkway. It is composed of sections of a number of numbered highways, including U.S. Route 441 (US 441) and US 321 and State Route 66 (SR 66) and SR 448.
U.S. Route 11E (US 11E) is a divided highway of US 11 in the U.S. states of Tennessee and Virginia. The United States Numbered Highway, which is complemented by US 11W to the north and west, runs 120.94 miles (194.63 km) from US 11, US 11W, and US 70 in Knoxville, Tennessee, north and east to US 11, US 11W, US 19, and US 421 in Bristol, Virginia. US 11E connects Knoxville and the twin cities of Bristol, Virginia, and Bristol, Tennessee, with the East Tennessee communities of Morristown, Greeneville, and Johnson City. The U.S. Highway runs concurrently with US 70 and US 25W east of Knoxville, US 321 from Greeneville and Johnson City, and both US 19W and US 19 between Johnson City and Bristol. US 11E also has an unsigned concurrency with State Route 34 (SR 34) for almost all of its course in Tennessee.
U.S. Route 25E (US 25E) is the eastern branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin. The highway, however, continues as US 25E for roughly two miles (3.2 km) until it joins Interstate 75 (I-75) in the Laurel County community of North Corbin at exit 29. The highway serves the Appalachia regions of Kentucky's Cumberland Plateau and the Ridge-and-Valley section of East Tennessee, including the urbanized areas of Corbin and Middlesboro in Kentucky and Morristown in Tennessee.
U.S. Route 25W (US 25W) is the western branch of US 25 from Newport, Tennessee, where US 25 splits into US 25E and US 25W, to North Corbin, Kentucky, where the two highways rejoin.
State Route 14 is a south–north route from the Mississippi border in Memphis, Tennessee to an intersection with State Route 54 in Tipton County.
State Route 9 (SR 9) is a west-to-east state highway in the U.S. state of Tennessee that is 131.33 miles (211.36 km) long. It begins in Campbell County and ends in Cocke County. SR 9 is little-known by the general public by this designation as it is overlain by U.S. Route 25W and U.S. Route 25 east of Newport; the "9" designation is seen on mileposts. The entire route is located in East Tennessee. Despite running concurrent with a North-South US Route, Route 9 is signed as east-west.
State Route 71 is a north–south state highway in Tennessee. For most of the length it is a "hidden" route, as it coincides with US 441 in all but a short section in Knoxville. The road begins at the North Carolina state line in Sevier County within the Great Smoky Mountains National Park at Newfound Gap and ends at an intersection with US 25W, SR 116, and SR 9 (hidden) in Rocky Top. Along its length SR 71 passes through Sevier County, a small portion of Blount County, Knox County, Anderson County, and in and out of Campbell County. Despite being signed on Hall of Fame Parkway in Knoxville, Tennessee, the Knox County TDOT map ignores SR 71 while SR 33 has a concurrency with US 441.
State Route 20 (SR 20) is a 143.04-mile (230.20 km) long east–west primary state highway that begins in Dyersburg and ending near Summertown. SR 20 is unsigned and concurrent with U.S. Route 412 (US 412) for its entire length, except for a short section between Hohenwald and Summertown. Along its route, SR 20 traverses parts of both Middle Tennessee and West Tennessee.
State Route 160 is a state highway in East Tennessee that has both four-lane expressway and two-lane rural collector sections. It serves as a arterial bypass route of US 11E/SR 34 in the city of Morristown in Hamblen County.
In Tennessee, U.S. Route 412 stretches for 181.93 miles (292.79 km) through the farmland of West Tennessee and the hills of Middle Tennessee, starting at the Missouri state line near Dyersburg and running to an interchange between I-65 and SR 99 in Columbia.
U.S. Route 441 (US 441) stretches for 83.28 miles (134.03 km) through the mountains of East Tennessee, connecting Rocky Top with Knoxville, Sevierville, Gatlinburg, and the Great Smoky Mountains National Park, crossing into North Carolina at Newfound Gap. Near its northern terminus, US 441 crosses over Norris Dam and passes through Norris Dam State Park.
State Route 70 is a state-maintained highway in East Tennessee, beginning at the border with North Carolina in the midst of the Cherokee National Forest and the Great Smoky Mountains and ending at the Virginia border in the extremely rural and mountainous terrain of Hancock County.
U.S. Route 421 is a north–south United States highway that runs for 43.4 miles (69.8 km) in East Tennessee, connecting the cities of Mountain City and Bristol.
State Route 186 is a state highway in the U.S. state of Tennessee. It runs from Trenton southward to Jackson, passing through the towns of Gibson and Three Way along the way. The southern portion serves as a western bypass for the city of Jackson, which is signed as U.S. Route 45 Bypass.
State Route 32 is a state highway in East Tennessee. For most of its route, it is an unsigned companion route concurrent with U.S. Route 25E. The highway stretches 89 miles from the North Carolina state line to the Tennessee-Kentucky state line near the town of Cumberland Gap.
State Route 113 is a north–south state highway in East Tennessee.
State Route 139 (SR 139) is a 25-mile-long (40 km) state highway in Jefferson and Sevier counties in the eastern portion of the U.S. state of Tennessee. It connects Strawberry Plains to Dandridge.
State Route 35 is a north–south state highway in East Tennessee. The 81.35 miles (130.92 km) long state highway traverses Blount, Sevier, a small portion of Jefferson, Cocke, and Greene Counties. Most of the route is a secret, or hidden designation, as it runs concurrently with U.S. Highways in the area.
US 441 / US 411 at Sevierville 
SR 31 / SR 33 at Sneedville 
