Hummer is an American brand of pickups and SUVs first marketed in 1992 when AM General began selling a civilian version of the M998 Humvee. Although discontinued in 2010, Hummer returned as a model under GMC in 2020. In 1998, General Motors (GM) purchased the brand name from AM General and marketed three vehicles: the original Hummer H1, based on the military Humvee, as well as the new H2 and H3 models that were based on smaller, civilian-market GM platforms.
In Internet computing, NSD is an open-source Domain Name System (DNS) server. It was developed by NLnet Labs of Amsterdam in cooperation with the RIPE NCC, from scratch as an authoritative name server. The intention of this development is to add variance to the "gene pool" of DNS implementations used by higher level name servers and thus increase the resilience of DNS against software flaws or exploits.
Histamine is an organic nitrogenous compound involved in local immune responses communication, as well as regulating physiological functions in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus. Discovered in 1910, histamine has been considered a local hormone (autocoid) because it's produced without involvement of the classic endocrine glands; however, in recent years, histamine has been recognized as a central neurotransmitter. Histamine is involved in the inflammatory response and has a central role as a mediator of itching. As part of an immune response to foreign pathogens, histamine is produced by basophils and by mast cells found in nearby connective tissues. Histamine increases the permeability of the capillaries to white blood cells and some proteins, to allow them to engage pathogens in the infected tissues. It consists of an imidazole ring attached to an ethylamine chain; under physiological conditions, the amino group of the side-chain is protonated.
Futures studies, futures research, futurism research, futurism, or futurology is the systematic, interdisciplinary and holistic study of social/technological advancement, and other environmental trends; often for the purpose of exploring how people will live and work in the future. Predictive techniques, such as forecasting, can be applied, but contemporary futures studies scholars emphasize the importance of systematically exploring alternatives. In general, it can be considered as a branch of the social sciences and an extension to the field of history. Futures studies seeks to understand what is likely to continue and what could plausibly change. Part of the discipline thus seeks a systematic and pattern-based understanding of past and present, and to explore the possibility of future events and trends.
Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons and control histamine turnover by feedback inhibition of histamine synthesis and release. The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.
The trihydrogen cation or protonated molecular hydrogen is a cation with formula H+3, consisting of three hydrogen nuclei (protons) sharing two electrons.
The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system. The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling pathway. Antihistamines, which act on this receptor, are used as anti-allergy drugs. The crystal structure of the receptor has been determined (shown on the right/below) and used to discover new histamine H1 receptor ligands in structure-based virtual screening studies.
In mathematics, the inverse problem for Lagrangian mechanics is the problem of determining whether a given system of ordinary differential equations can arise as the Euler–Lagrange equations for some Lagrangian function.
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. Typically, people take antihistamines as an inexpensive, generic drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. Antihistamines are usually for short-term treatment. Chronic allergies increase the risk of health problems which antihistamines might not treat, including asthma, sinusitis, and lower respiratory tract infection. Consultation of a medical professional is recommended for those who intend to take antihistamines for longer-term use.
An H3 receptor antagonist is a type of antihistaminic drug used to block the action of histamine at H3 receptors.
Technology scouting is an element of technology management in which
A climate change scenario is a hypothetical future based on a "set of key driving forces". Scenarios explore the long-term effectiveness of mitigation and adaptation. Scenarios help to understand what the future may hold. They can show which decisions will have the most meaningful effects on mitigation and adaptation.
Junior colleges (JC) are pre-university institutions in Singapore that offer two-year pre-university courses that leads to either the Singapore-Cambridge GCE Advanced Level or the International Baccalaureate Diploma. Admission to Junior college is based on the aggregate raw score of 20 points or less in O-Level "L1R5" in the examination. Lower aggregate is considered better, i e. 7 aggregate score is better than aggregate score 10. Bonus points are also deducted from this proscore to come up with the final score for the admission.
The Singapore-Cambridge General Certificate of Education Advanced Level is a GCE Advanced Level examination held annually in Singapore and is jointly conducted by the Ministry of Education (MOE), Singapore Examinations and Assessment Board (SEAB) and the University of Cambridge Local Examinations Syndicate (UCLES).
Dana Klisanin is a psychologist, futurist, and author best known for her research and writing in the field of digital altruism and the impact of the digital era on heroism. Her research was recognized in 2012 by the American Psychological Association with an award for Early Career Scientific Contribution to Media Psychology. In 2017, Klisanin was the recipient of the President's Outstanding Woman Futurist Award, as recognized by the World Futures Studies Federation (WFSF). In 2020, Klisanin was named one Forbes' "50 Leading Female Futurists." As a novelist, Klisanin is the author of Future Hack, the first installment in a series entitled Chronicles of G.A.I.A.
In the fields of engineering and construction, resilience is the ability to absorb or avoid damage without suffering complete failure and is an objective of design, maintenance and restoration for buildings and infrastructure, as well as communities. A more comprehensive definition is that it is the ability to respond, absorb, and adapt to, as well as recover in a disruptive event. A resilient structure/system/community is expected to be able to resist to an extreme event with minimal damages and functionality disruptions during the event; after the event, it should be able to rapidly recovery its functionality similar to or even better than the pre-event level.
Causal layered analysis (CLA) is a future research theory that integrates various epistemic modes, creates spaces for alternative futures, and consists of four layers: litany, social, and structural, worldview, and myth/metaphor. The method was created by Sohail Inayatullah, a Pakistani-Australian futures studies researcher.
The Stockholm Resilience Centre (SRC), is a research centre on resilience and sustainability science at Stockholm University. It is a joint initiative between Stockholm University and the Beijer Institute of Ecological Economics at the Royal Swedish Academy of Sciences.
Climate-smart agriculture (CSA) is a set of farming methods that has three main objectives with regards to climate change. Firstly, they use adaptation methods to respond to the effects of climate change on agriculture. Secondly, they aim to increase agricultural productivity and to ensure food security for a growing world population. Thirdly, they try to reduce greenhouse gas emissions from agriculture as much as possible. Climate-smart agriculture works as an integrated approach to managing land. This approach helps farmers to adapt their agricultural methods to the effects of climate change.
Horizon scanning (HS) or horizon scan is a method from futures studies, sometimes regarded as a part of foresight. It is the early detection and assessment of emerging technologies or threats for mainly policy makers in a domain of choice. Such domains include agriculture, environmental studies, health care, biosecurity, and food safety.
