Trihydroxystilbene synthase

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trihydroxystilbene synthase
Identifiers
EC no. 2.3.1.95
CAS no. 128449-70-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a trihydroxystilbene synthase (EC 2.3.1.95) is an enzyme that catalyzes the chemical reaction

Contents

3 malonyl-CoA + 4-coumaroyl-CoA 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and 4-coumaroyl-CoA, whereas its 3 products are CoA, 3,4',5-trihydroxy-stilbene (resveratrol), and CO2.

This enzyme belongs to the family of transferases, To be specific those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing). Other names in common use include resveratrol synthase, and stilbene synthase. [1] This enzyme participates in phenylpropanoid biosynthesis. [1] [2]

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Z1E [3] and 1Z1F. [3]

References

  1. 1 2 Valletta, Alessio; Iozia, Lorenzo Maria; Leonelli, Francesca (January 2021). "Impact of Environmental Factors on Stilbene Biosynthesis". Plants. 10 (1): 90. doi: 10.3390/plants10010090 . PMC   7823792 . PMID   33406721.
  2. Dubrovina, A. S.; Kiselev, K. V. (October 2017). "Regulation of stilbene biosynthesis in plants" . Planta. 246 (4): 597–623. doi:10.1007/s00425-017-2730-8. ISSN   0032-0935. PMID   28685295. S2CID   4015467.
  3. 1 2 Shomura Y, Torayama I, Suh DY, Xiang T, Kita A, Sankawa U, Miki K (September 2005). "Crystal structure of stilbene synthase from Arachis hypogaea". Proteins. 60 (4): 803–6. doi:10.1002/prot.20584. PMID   16028220. S2CID   44490134.

Further reading