Interstate 25 (I-25), also known as the Pan-American Freeway, is a major Interstate Highway in the western United States. It is primarily a north–south highway, serving as the main route through New Mexico, Colorado, and Wyoming. I-25 stretches from I-10 at Las Cruces, New Mexico to I-90 in Buffalo, Wyoming. It passes through or near Albuquerque, New Mexico; Pueblo, Colorado; Colorado Springs, Colorado; Denver, Colorado; Fort Collins, Colorado; and Cheyenne, Wyoming. The I-25 corridor is mainly rural, especially in Wyoming, excluding the Albuquerque metropolitan area and the Front Range urban corridor from Pueblo to Cheyenne.
U.S. Route 180 is an east–west United States highway. Like many three-digit routes, US 180 no longer meets its "parent", US 80. US 80 was decommissioned west of Mesquite, Texas, and was replaced in Texas by Interstate 20 and Interstate 10 resulting in U.S. 180 being 57 miles longer than U.S. 80. The highway's eastern terminus is in Hudson Oaks, Texas, at an intersection with Interstate 20. Its western terminus is unclear. Signage at an intersection with State Route 64 in Valle, Arizona 40 miles (64 km) northwest of Flagstaff indicates that the route starts at SR 64, which is consistent with the AASHTO U.S. Highway logs. However, many maps continue the US 180 designation to the south rim of the Grand Canyon at Grand Canyon Village. Signage at the SR 64 intersection as of 2021 indicated that US 180 continues north concurrent with the route. However, no signage along the route exists past this intersection until SR 64 turns east towards Cameron, Arizona. At this intersection, signage makes no mention of US 180 nor is there any mention at the terminus of SR 64 at US 89.
U.S. Route 285 is a north–south United States highway, running 846 miles (1,362 km) through the states of Texas, New Mexico and Colorado. The highway's southern terminus is in Sanderson, Texas at an intersection with U.S. Route 90. US 285 has always had an endpoint in Denver, Colorado, although the original US 285 went north from Denver. Today the highway's northern terminus is in Denver, at exit 201 on Interstate 25.
U.S. Route 60 is a major east–west United States highway, traveling 2,655 miles (4,273 km) from southwestern Arizona to the Atlantic Ocean coast in Virginia. The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as General Booth Boulevard, just south of the city's Oceanfront resort district at the intersection of Rudee Point Road and Harbor Point. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California, but in 1964, it was truncated to end southwest of Brenda, Arizona, at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. I-10 replaced US 60 from Beaumont, California, to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.
U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".
U.S. Route 84 (US 84) is an east–west United States Numbered Highway that started as a short Georgia–Alabama route in the original 1926 scheme. Later, in 1941, it had been extended all the way to Colorado. The highway's eastern terminus is a short distance east of Midway, Georgia, at an Interchange with Interstate 95 (I-95). The road continues toward the nearby Atlantic Ocean as a county road. Its western terminus is in Pagosa Springs, Colorado, at an intersection with US 160.
U.S. Route 62 or U.S. Highway 62 (US 62) is an east–west United States Highway in the southern and northeastern United States. It runs from the Mexican border at El Paso, Texas, to Niagara Falls, New York, near the Canadian border. It is the only east–west United States Numbered Highway that connects Mexico and Canada. Parts of US 62 follow what once was the Ozark Trail, including the historic bridge across the South Canadian River in Newcastle, Oklahoma. This bridge was damaged beyond repair by the 2013 Moore tornado that struck Newcastle and Moore, Oklahoma. The highway runs north–south in New York and Pennsylvania.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route. Truckers refer to this road as "The Bee Line."
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
U.S. Route 85 (US 85) is a 1,479-mile-long (2,380 km) north–south United States Highway that travels in the Mountain and Northern Plains states of the United States. The southern terminus of the highway is at the Mexican border in El Paso, Texas, connecting with Mexican Federal Highway 45. The northern terminus is at the Canadian border in Fortuna, North Dakota, where the route continues north as Saskatchewan Highway 35. The highway route is part of the CanAm Highway. Sections of US 85 are designated as the Theodore Roosevelt Expressway.
U.S. Highway 87 is a north–south United States highway that runs for 1,998 miles (3,215 km) from northern Montana to southern Texas, making it the longest north-south road to not have a "1" in its number and the third longest north-south road in the country, behind U.S. 41 and U.S. 1. Most of the portion from Billings, Montana to Raton, New Mexico is co-signed along Interstates 90 and 25. It is also co-signed along the majority of I-27 in Texas and future plans call for the interstate to be extended along the US 87 corridor. As of 2004, the highway's northern terminus is in Havre, Montana, at US 2 and its southern terminus is in Port Lavaca, Texas, at SH 238.
U.S. Highway 60 in Texas is a 210.70-mile-long U.S. Highway that runs southwest to northeast through the Texas Panhandle. The route passes through the cities of Hereford, Canyon, Amarillo, and Canadian.
U.S. Route 60 (US 60) is an east–west United States Highway within New Mexico. It begins at the Arizona state line and continues east to the Texas state line.
New Mexico Road 599 (NM 599) is a 14.019-mile (22.561 km) state highway in northern Santa Fe County, New Mexico, United States. The divided highway expressway is also known as the Veterans Memorial Highway and the Santa Fe Relief Route; and both names are used on road signs. The latter name alludes to the highway's original purpose of bypassing the urbanized areas of Santa Fe and thereby relieving it from shipments of hazardous waste. It passes through less densely developed terrain in and around the northwestern boundary of the municipality. Speed limits on it range from 45 to 65 miles per hour.
U.S. Route 285 (US 285) is a north–south U.S. highway that runs from Sanderson, TX to Denver, CO. US 285 enters the state of New Mexico from Texas, into Eddy County, NM just south of Loving. The highway runs through the major cities of Carlsbad, Roswell, and Santa Fe. The highway exits the state into Colorado approximately 25 miles north of Tres Piedras. The Pecos River runs adjacent to the vast stretch of highway, yet breaks away in Northern New Mexico, before entering Colorado.
New Mexico State Road 17 (NM 17) is a 9.59-mile-long (15.43 km) state highway in Rio Arriba County, New Mexico. Its southern end is at US 64-84 in Chama and its northern end is at Colorado State Highway 17 at the Colorado state line.
Interstate business routes are roads connecting a central or commercial district of a city or town with an Interstate bypass. These roads typically follow along local streets often along a former US or state highway that had been replaced by an Interstate. Interstate business route reassurance markers are signed as either loops or spurs using a green shield shaped sign and numbered like the shield of the parent Interstate Highway.
U.S. Route 85 (US 85) is a part of the U.S. Highway System that travels from the Mexican border in El Paso, Texas, north to the Canadian border in Fortuna, North Dakota. In the U.S. state of Colorado, US 85 begins at the New Mexico state line south of Starkville and ends at the Wyoming state line south of Cheyenne, Wyoming.
State Road 584 (NM 584), also known as Fairview Lane, is a 1.277-mile (2.055 km) east–west state highway in northern Española, New Mexico, United States, that connects U.S. Route 84/U.S. Route 285 (US 84/US 285) with New Mexico State Road 68 (NM 68).
US 84 at the Colorado state line
US 64 from west of Chama to Tierra Amarilla 
US 70 in Clovis 
