| UDP-N-acetylglucosamine 2-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.1.3.14 | ||||||||
| CAS no. | 9037-71-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
| UDP-N-acetylglucosamine 2-epimerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of udp-n-acetylglucosamine_2 epimerase | |||||||||
| Identifiers | |||||||||
| Symbol | Epimerase_2 | ||||||||
| Pfam | PF02350 | ||||||||
| Pfam clan | CL0113 | ||||||||
| InterPro | IPR003331 | ||||||||
| SCOP2 | 1f6d / SCOPe / SUPFAM | ||||||||
| CDD | cd03786 | ||||||||
| |||||||||
In enzymology, an UDP-N-acetylglucosamine 2-epimerase [note 1] (EC 5.1.3.14) is an enzyme that catalyzes the chemical reaction
Contents
- UDP-N-acetyl-D-glucosamine UDP-N-acetyl-D-mannosamine
Hence, this enzyme has one substrate, UDP-N-acetyl-D-glucosamine, and one product, UDP-N-acetyl-D-mannosamine.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine 2-epimerase. Other names in common use include UDP-N-acetylglucosamine 2'-epimerase, uridine diphosphoacetylglucosamine 2'-epimerase, uridine diphospho-N-acetylglucosamine 2'-epimerase, and uridine diphosphate-N-acetylglucosamine-2'-epimerase. This enzyme participates in aminosugars metabolism.
In microorganisms this epimerase is involved in the synthesis of the capsule precursor UDP-ManNAcA. [1] [2] An inhibitor of the bacterial 2-epimerase, epimerox, has been described. Some of these enzymes are bifunctional. The UDP-N-acetylglucosamine 2-epimerase from rat liver displays both epimerase and kinase activity. [3]
