Parent institution | University of Oxford Wellcome Trust |
---|---|
Established | 1994 |
Director | John Todd |
Staff | 470 |
Key people | Yvonne Jones (deputy director) |
Formerly called | Wellcome Trust Center for Human Genetics |
Location | Henry Wellcome Building of Genomic Medicine, Oxford |
Coordinates | 51°45′08″N1°12′55″W / 51.752248°N 1.215255°W |
Website | www |
The Wellcome Centre for Human Genetics is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others. [1]
The centre is located at the Henry Wellcome Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director. [2] [3]
Within the WHG a number of 'cores' provide services to the researchers:
The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq. [4] They also offer Oxford Nanopore MinION and PromethION sequencing. [4] There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and Fluidigm. [5]
The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage. [6]
The Transgenics Core provides access to genetically modified mice and cell lines. [7]
Cellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy (FCS), Fluorescence Lifetime Correlation Spectroscopy (FLCS), Fluorescence Lifetime Imaging Microscopy (FLIM), Total Internal Reflection Fluorescence Microscopy (TIRF), Photoactivated Localisation Microscopy (PALM), Spectral Imaging (SI) and Single Particle Tracking (SPT). [8]
The WHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project. [9]
The Wellcome Sanger Institute, previously known as The Sanger Centre and Wellcome Trust Sanger Institute, is a non-profit British genomics and genetics research institute, primarily funded by the Wellcome Trust.
The Department of Materials at the University of Oxford, England was founded in the 1950s as the Department of Metallurgy, by William Hume-Rothery, who was a reader in Oxford's Department of Inorganic Chemistry. It is part of the university's Mathematical, Physical and Life Sciences Division
Watt Wetmore Webb was an American biophysicist, known for his co-invention of multiphoton microscopy in 1990.
Dame Kay Elizabeth Davies is a British geneticist. She is Dr Lee's Professor of Anatomy at the University of Oxford and a Fellow of Hertford College, Oxford. She is director of the Medical Research Council (MRC) functional genetics unit, a governor of the Wellcome Trust, a director of the Oxford Centre for Gene Function, and a patron and Senior Member of Oxford University Scientific Society. Her research group has an international reputation for work on Duchenne muscular dystrophy (DMD). In the 1980s, she developed a test which allowed for the screening of foetuses whose mothers have a high risk of carrying DMD.
The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge, England.
Andor Technology Ltd is a global developer and manufacturer of high-performance scientific cameras, microscopy systems and spectrographs for academic, government, and industrial applications. Founded in 1989, the company's products play a central role in the advancement of research in the fields of life sciences, physical sciences, and industrial applications. Andor was purchased for £176 million in December 2013 by Oxford Instruments. The company is based in Belfast, Northern Ireland and now employs over 400 staff across the group at its offices in Belfast, Japan, China, Switzerland and the US.
The Centre for Applied Genomics is a genome centre in the Research Institute of The Hospital for Sick Children, and is affiliated with the University of Toronto. TCAG also operates as a Science and Technology Innovation Centre of Genome Canada, with an emphasis on next-generation sequencing (NGS) and bioinformatics support. Research at TCAG focuses on the genetic and genomic basis of human variability, health and disease, including research on the genetics of autism spectrum disorder and structural variation of the human genome. The centre is located in the Peter Gilgan Centre for Research and Learning in downtown Toronto, Canada.
Gilean Alistair Tristram McVean is a professor of statistical genetics at the University of Oxford, fellow of Linacre College, Oxford and co-founder and director of Genomics plc. He also co-chaired the 1000 Genomes Project analysis group.
Richard Mott is Weldon Professor of Computational and Statistical Genetics in the research department of Genetics, Evolution and Environment at University College London. He was previously at the Wellcome Centre for Human Genetics and a Professor by Research at Oxford University.
John Andrew Todd FMedSci FRS is Professor of Precision Medicine at the University of Oxford, director of the Wellcome Center for Human Genetics and the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, in addition to Jeffrey Cheah Fellow in Medicine at Brasenose College. He works in collaboration with David Clayton and Linda Wicker to examine the molecular basis of type 1 diabetes.
The Centre for Cellular and Molecular Platforms (C-CAMP) is an initiative of the Department of Biotechnology, Ministry of Science, Technology and Earth Sciences, Govt. of India. Established in 2009 with a mandate to enable cutting edge Life Sciences Research and Innovation, C-CAMP is the country's most exciting life sciences innovation hub bringing together academia, industry and the startup ecosystem - all on one platform. It is also a part of the one of the country's earliest bio-clusters, the Bangalore Bio-Cluster.
Transmission electron microscopy DNA sequencing is a single-molecule sequencing technology that uses transmission electron microscopy techniques. The method was conceived and developed in the 1960s and 70s, but lost favor when the extent of damage to the sample was recognized.
The various academic faculties, departments, and institutes of the University of Oxford are organised into four divisions, each with its own Head and elected board. They are the Humanities Division; the Social Sciences Division; the Mathematical, Physical and Life Sciences Division; and the Medical Sciences Division.
Wolf Reik FRS is a German molecular biologist and a group leader at the Babraham Institute, honorary professor of Epigenetics at the University of Cambridge and associate faculty at the Wellcome Trust Sanger Institute. He was announced as the director of Altos Labs Cambridge Institute when the company launched on 19 January 2022.
Sir David Klenerman is a British biophysical chemist and a professor of biophysical chemistry at the Department of Chemistry at the University of Cambridge and a Fellow of Christ's College, Cambridge.
The Centre for Genomic Regulation is a biomedical and genomics research centre based on Barcelona. Most of its facilities and laboratories are located in the Barcelona Biomedical Research Park, in front of Somorrostro beach.
Nicole Soranzo is an Italian-British senior group leader in human genetics at the Wellcome Sanger Institute, Professor of Human Genetics at the University of Cambridge. She is an internationally recognised Human Geneticist who has focused on the application of cutting edge genomic technologies to study the spectrum of human genetic variation associated with cardio-metabolic and immune diseases. She has led many large-scale discovery efforts including more than 1,000 novel genetic variants associated with cardio-metabolic diseases and their risk factors as well as establishing the HaemGen consortium, which is a worldwide effort to discover genetic determinants of blood cell formation and also interpretation of the downstream consequences of sequence variation through a host of integrative analyses and functional approaches.
Irene Mary Carmel Tracey is Vice-Chancellor of the University of Oxford and former Warden of Merton College, Oxford. She is also Professor of Anaesthetic Neuroscience in the Nuffield Department of Clinical Neurosciences and formerly Pro-Vice-Chancellor at the University of Oxford. She is a co-founder of the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), now the Wellcome Centre for Integrative Neuroimaging. Her team’s research is focused on the neuroscience of pain, specifically pain perception and analgesia as well as how anaesthetics produce altered states of consciousness. Her team uses multidisciplinary approaches including neuroimaging.
Cecilia Margareta Lindgren is a Swedish geneticist. She is a Professor of Genomic Endocrinology & Metabolism in the Nuffield Department of Population Health at the University of Oxford, where she is also Group Head at the Wellcome Centre for Human Genetics and a research fellow at St. Anne's College. She became Director of the Big Data Institute at Oxford on 1 April 2021; she had previously been a Senior Group Leader at the Institute. Lindgren is best known for her research on the genetics of obesity and other complex traits.