Zinc finger protein 426

ZNF426
Identifiers
Aliases	ZNF426 , K-RBP, zinc finger protein 426
External IDs	MGI: 1920248 HomoloGene: 23435 GeneCards: ZNF426
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 9,523,223 bp [1] End 9,538,645 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9 A3|9 7.55 cM Start 20,379,845 bp [2] End 20,404,042 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte cavity of mouth amniotic fluid parotid gland epithelium of esophagus retinal pigment epithelium vena cava Achilles tendon sperm Top expressed in spermatid spermatocyte mirror ganglionic eminence secondary oocyte proximal tubule pituitary gland thymus urethra male urethra More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79088 235028 Ensembl ENSG00000130818 ENSMUSG00000059475 UniProt Q9BUY5 Q8R1D1 RefSeq (mRNA) NM_001300883 NM_024106 NM_001318055 NM_001318056 NM_001110309 NM_146221 NM_001310742 RefSeq (protein) NP_001287812 NP_001304984 NP_001304985 NP_077011 NP_001103779 NP_001297671 NP_666333 Location (UCSC) Chr 19: 9.52 – 9.54 Mb Chr 9: 20.38 – 20.4 Mb PubMed search [3] [4]
Wikidata
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Zinc finger protein 426 is a protein that in humans is encoded by the ZNF426 gene. ^[5]

Function

Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene.

References

1. GRCh38: Ensembl release 89: ENSG00000130818 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059475 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Zinc finger protein 426" . Retrieved 2016-01-28.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.