2-alkenal reductase

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2-alkenal reductase
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Leukotriene B4 12-hydroxydehydrogenase (NADP-dependent) dimer, Human
Identifiers
EC no. 1.3.1.74
CAS no. 9032-20-6
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IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, a 2-alkenal reductase (EC 1.3.1.74) is an enzyme that catalyzes the chemical reaction

n-alkanal + NAD(P)+ alk-2-enal + NAD(P)H + H+

The 3 substrates of this enzyme are n-alkanal, NAD+, and NADP+, whereas its 4 products are alk-2-enal, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is n-alkanal:NAD(P)+ 2-oxidoreductase. Other names in common use include NAD(P)H-dependent alkenal/one oxidoreductase, and NADPH:2-alkenal alpha,beta-hydrogenase.

Structural studies

As of late 2007, three structures have been solved for this class of enzymes, with PDB accession codes 2DM6, 2J3J, and 2J3K.

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References


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