3-oxo-5beta-steroid 4-dehydrogenase

3-oxo-5-beta-steroid 4-dehydrogenase
Identifiers
EC no.	1.3.99.6
CAS no.	9067-97-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, 3-oxo-5beta-steroid 4-dehydrogenase (EC 1.3.99.6) is an enzyme that catalyzes the chemical reaction

a 3-oxo-5beta-steroid + acceptor ${\displaystyle \rightleftharpoons }$ a 3-oxo-Delta₄-steroid + reduced acceptor

For example, the enzyme acts on 5β-dihydroprogesterone to give progesterone. ^{[1] [2]}

5β-Dihydroprogesterone

+ electron acceptor

 

 

 

 

 

 

 

Progesterone

+ reduced acceptor

 

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxo-5beta-steroid:acceptor Delta4-oxidoreductase. This enzyme is also called 3-oxo-5beta-steroid:(acceptor) Delta4-oxidoreductase. This enzyme participates in 3 metabolic pathways: bile acid biosynthesis, c21-steroid hormone metabolism, and androgen and estrogen metabolism.

References

1. Enzyme 1.3.99.6 at KEGG Pathway Database.
2. Davidson SJ, Talalay P (1966). "Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase". J. Biol. Chem. 241 (4): 906–15. doi: 10.1016/S0021-9258(18)96851-1 . PMID   5907467.