| Race details | |||
|---|---|---|---|
| Race 17 of 22 in the 2021 NASCAR Camping World Truck Series season | |||
 | |||
| Date | September 4, 2021 | ||
| Location | Darlington Raceway, Darlington, South Carolina | ||
| Course | Permanent racing facility 1.366 mi (2.198 km) | ||
| Distance | 147 laps, 200.802 mi (323.106 km) | ||
| Scheduled Distance | 147 laps, 200.802 mi (323.106 km) | ||
| Average speed | 105.331 miles per hour (169.514 km/h) | ||
| Pole position | |||
| Driver | GMS Racing | ||
| Grid positions set by competition-based formula | |||
| Most laps led | |||
| Driver | Sheldon Creed | GMS Racing | |
| Laps | 104 | ||
| Winner | |||
| No. 2 | Sheldon Creed | GMS Racing | |
| Television in the United States | |||
| Network | FS1 | ||
| Announcers | Vince Welch, Michael Waltrip, Ricky Carmichael | ||
| Radio in the United States | |||
| Radio | MRN | ||
The 2021 In It To Win It 200 presented by the South Carolina Education Lottery was the 17th stock car race of the 2021 NASCAR Camping World Truck Series, and the inaugural running of the 2nd Darlington Raceway truck race. The race was held in Darlington, South Carolina at Darlington Raceway, a 1.366 miles (2.198 km) egg-shaped oval on September 4, 2021, over 147 laps. Sheldon Creed of GMS Racing would win the race, leading 104 laps. John Hunter Nemechek of Kyle Busch Motorsports and Stewart Friesen of Halmar Friesen Racing would take 2nd and 3rd, respectively.
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