3-oxosteroid 1-dehydrogenase

Last updated
3-oxosteroid 1-dehydrogenase
Identifiers
EC no. 1.3.99.4
CAS no. 9029-04-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, a 3-oxosteroid 1-dehydrogenase (EC 1.3.99.4) is an enzyme that catalyzes the chemical reaction

a 3-oxosteroid + acceptor a 3-oxo-Delta1-steroid + reduced acceptor

Thus, the two substrates of this enzyme are 3-oxosteroid and acceptor, whereas its two products are 3-oxo-Delta1-steroid and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxosteroid:acceptor Delta1-oxidoreductase. Other names in common use include 3-oxosteroid Delta1-dehydrogenase, Delta1-dehydrogenase, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-Delta1-dehydrogenase, 1-ene-dehydrogenase, 3-oxosteroid:(2,6-dichlorphenolindophenol) Delta1-oxidoreductase, 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase, Delta1-steroid reductase, and 3-oxosteroid:(acceptor) Delta1-oxidoreductase.

Related Research Articles

In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor. This group of enzymes usually utilizes NADP+ or NAD+ as cofactors. Transmembrane oxidoreductases create electron transport chains in bacteria, chloroplasts and mitochondria, including respiratory complexes I, II and III. Some others can associate with biological membranes as peripheral membrane proteins or be anchored to the membranes through a single transmembrane helix.

<span class="mw-page-title-main">5α-Reductase</span> Enzyme family

5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism. There are three isozymes of 5α-reductase encoded by the genes SRD5A1, SRD5A2, and SRD5A3.

3β-Hydroxysteroid dehydrogenase/Δ5-4 isomerase (3β-HSD) is an enzyme that catalyzes the biosynthesis of the steroid progesterone from pregnenolone, 17α-hydroxyprogesterone from 17α-hydroxypregnenolone, and androstenedione from dehydroepiandrosterone (DHEA) in the adrenal gland. It is the only enzyme in the adrenal pathway of corticosteroid synthesis that is not a member of the cytochrome P450 family. It is also present in other steroid-producing tissues, including the ovary, testis and placenta. In humans, there are two 3β-HSD isozymes encoded by the HSD3B1 and HSD3B2 genes.

<span class="mw-page-title-main">Hydroxysteroid dehydrogenase</span>

Hydroxysteroid dehydrogenases (HSDs) are a group of alcohol oxidoreductases that catalyze the dehydrogenation of hydroxysteroids. These enzymes also catalyze the reverse reaction, acting as ketosteroid reductases (KSRs).

In enzymology, a cholest-5-ene-3β,7α-diol 3β-dehydrogenase (EC 1.1.1.181) is an enzyme that catalyzes the chemical reaction

In enzymology, a 4-oxoproline reductase (EC 1.1.1.104) is an enzyme that catalyzes the chemical reaction

In enzymology, a 12alpha-hydroxysteroid dehydrogenase (EC 1.1.1.176) is an enzyme that catalyzes the chemical reaction

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3alpha-hydroxysteroid dehydrogenase (A-specific) (EC 1.1.1.213) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">3alpha(or 20beta)-hydroxysteroid dehydrogenase</span> Class of enzymes

In enzymology, a 3alpha(or 20beta)-hydroxysteroid dehydrogenase (EC 1.1.1.53) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3-keto-steroid reductase (EC 1.1.1.270) is an enzyme that catalyzes the chemical reaction

In enzymology, a 3-oxo-5beta-steroid 4-dehydrogenase is an enzyme that catalyzes the chemical reaction

In enzymology, a 6-hydroxynicotinate reductase is an enzyme that catalyzes the chemical reaction

In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction

In enzymology, a cortisone alpha-reductase (EC 1.3.1.4) is an enzyme that catalyzes the chemical reaction

In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">NAD(P)H dehydrogenase (quinone)</span>

In enzymology, a NAD(P)H dehydrogenase (quinone) (EC 1.6.5.2) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">SRD5A1</span> Protein-coding gene in the species Homo sapiens

3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. It is one of three forms of steroid 5α-reductase.

<span class="mw-page-title-main">Steroid Delta-isomerase</span>

In enzymology, a steroid Δ5-isomerase is an enzyme that catalyzes the chemical reaction

5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (EC 1.3.1.3, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase. This enzyme catalyses the following chemical reaction

References