AS3MT

AS3MT
Identifiers
Aliases	AS3MT , CYT19, arsenite methyltransferase
External IDs	OMIM: 611806; MGI: 1929882; HomoloGene: 10754; GeneCards: AS3MT; OMA:AS3MT - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 102,869,470 bp [1] End 102,901,899 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 46,695,897 bp [2] End 46,729,538 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland right adrenal cortex left adrenal cortex right lobe of liver apex of heart left ventricle ganglionic eminence ventricular zone right auricle of heart spleen Top expressed in yolk sac right kidney soleus muscle proximal tubule interventricular septum median eminence arcuate nucleus myocardium of ventricle neural layer of retina Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function methyltransferase activity transferase activity methylarsonite methyltransferase activity arsenite methyltransferase activity Cellular component cytosol cytoplasm Biological process toxin metabolic process arsonoacetate metabolic process methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57412 57344 Ensembl ENSG00000214435 ENSMUSG00000003559 UniProt Q9HBK9 Q91WU5 RefSeq (mRNA) NM_020682 NM_020577 RefSeq (protein) NP_065733 NP_065602 Location (UCSC) Chr 10: 102.87 – 102.9 Mb Chr 19: 46.7 – 46.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000214435 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003559 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ (March 2002). "A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol". The Journal of Biological Chemistry. 277 (13): 10795–803. doi: 10.1074/jbc.M110246200 . PMID   11790780.
6. "Entrez Gene: AS3MT arsenic (+3 oxidation state) methyltransferase".

Further reading

• Dheeman DS, Packianathan C, Pillai JK, Rosen BP (November 2014). "Pathway of human AS3MT arsenic methylation". Chemical Research in Toxicology. 27 (11): 1979–89. doi:10.1021/tx500313k. PMC   4237493 . PMID   25325836.
• Hernández A, Xamena N, Sekaran C, Tokunaga H, Sampayo-Reyes A, Quinteros D, Creus A, Marcos R (April 2008). "High arsenic metabolic efficiency in AS3MT287Thr allele carriers". Pharmacogenetics and Genomics. 18 (4): 349–55. doi:10.1097/FPC.0b013e3282f7f46b. PMID   18334919. S2CID   25842224.
• Fujihara J, Kunito T, Agusa T, Yasuda T, Iida R, Fujii Y, Takeshita H (December 2007). "Population differences in the human arsenic (+3 oxidation state) methyltransferase (AS3MT) gene polymorphism detected by using genotyping method". Toxicology and Applied Pharmacology. 225 (3): 251–4. doi:10.1016/j.taap.2007.08.010. PMID   17889916.
• Hernández A, Xamena N, Surrallés J, Sekaran C, Tokunaga H, Quinteros D, Creus A, Marcos R (January 2008). "Role of the Met(287)Thr polymorphism in the AS3MT gene on the metabolic arsenic profile". Mutation Research. 637 (1–2): 80–92. doi:10.1016/j.mrfmmm.2007.07.004. PMID   17850829.
• Lindberg AL, Kumar R, Goessler W, Thirumaran R, Gurzau E, Koppova K, Rudnai P, Leonardi G, Fletcher T, Vahter M (July 2007). "Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms". Environmental Health Perspectives. 115 (7): 1081–6. doi:10.1289/ehp.10026. PMC   1913583 . PMID   17637926.
• Schläwicke Engström K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M (April 2007). "Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina". Environmental Health Perspectives. 115 (4): 599–605. doi:10.1289/ehp.9734. PMC   1852682 . PMID   17450230.
• Meza M, Gandolfi AJ, Klimecki WT (August 2007). "Developmental and genetic modulation of arsenic biotransformation: a gene by environment interaction?". Toxicology and Applied Pharmacology. 222 (3): 381–7. doi:10.1016/j.taap.2006.12.018. PMC   2040165 . PMID   17306849.
• Wood TC, Salavagionne OE, Mukherjee B, Wang L, Klumpp AF, Thomae BA, Eckloff BW, Schaid DJ, Wieben ED, Weinshilboum RM (March 2006). "Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies". The Journal of Biological Chemistry. 281 (11): 7364–73. doi: 10.1074/jbc.M512227200 . PMID   16407288.
• Meza MM, Yu L, Rodriguez YY, Guild M, Thompson D, Gandolfi AJ, Klimecki WT (June 2005). "Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children". Environmental Health Perspectives. 113 (6): 775–81. doi:10.1289/ehp.7780. PMC   1257606 . PMID   15929903.
• Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ (April 2005). "Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype". Toxicology and Applied Pharmacology. 204 (2): 164–9. doi:10.1016/j.taap.2004.12.002. PMID   15808521.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• Human AS3MT genome location and AS3MT gene details page in the UCSC Genome Browser .