Adipocyte protein 2

Last updated

FABP4
2HNX.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FABP4 , A-FABP, AFABP, ALBP, HEL-S-104, aP2, fatty acid binding protein 4
External IDs OMIM: 600434 MGI: 88038 HomoloGene: 36067 GeneCards: FABP4
Gene location (Human)
Ideogram human chromosome 8.svg
Chr. Chromosome 8 (human) [1]
Human chromosome 8 ideogram.svg
HSR 1996 II 3.5e.svg
Red rectangle 2x18.png
Band 8q21.13Start81,478,419 bp [1]
End81,483,236 bp [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001442

NM_024406

RefSeq (protein)

NP_001433

NP_077717

Location (UCSC) Chr 8: 81.48 – 81.48 Mb Chr 3: 10.2 – 10.21 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

aP2 (adipocyte Protein 2) [5] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs [6] has the possibility of treating heart disease and the metabolic syndrome. [7]

See also

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170323 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062515 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry. 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID   2481498.
  6. Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A (September 2017). "Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review". European Journal of Medicinal Chemistry. 138: 854–873. doi:10.1016/j.ejmech.2017.07.022. PMID   28738306.
  7. Furuhashi M (March 2019). "Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases". Review. 26 (3): 216–232. doi:10.5551/jat.48710. PMC   6402888 .Cite journal requires |journal= (help)