FABP2

Last updated
FABP2
Protein FABP2 PDB 1kzw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FABP2 , FABPI, I-FABP, fatty acid binding protein 2
External IDs OMIM: 134640 MGI: 95478 HomoloGene: 107 GeneCards: FABP2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000134

NM_007980

RefSeq (protein)

NP_000125

NP_032006

Location (UCSC) Chr 4: 119.32 – 119.32 Mb Chr 3: 122.69 – 122.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a protein that in humans is encoded by the FABP2 gene. [5]

Contents

Function

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. [5]

Clinical significance

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [5]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145384 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023057 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 "Entrez Gene: FABP2 fatty acid binding protein 2, intestinal".

Further reading